PMID- 32290271
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 4
DP  - 2020 Apr 10
TI  - Effects of Whey Protein Supplementation on Aortic Stiffness, Cerebral Blood Flow, 
      and Cognitive Function in Community-Dwelling Older Adults: Findings from the 
      ANCHORS A-WHEY Clinical Trial.
LID - 10.3390/nu12041054 [doi]
LID - 1054
AB  - ANCHORS A-WHEY was a 12-week randomized controlled trial (RCT) designed to 
      examine the effect of whey protein on large artery stiffness, cerebrovascular 
      responses to cognitive activity and cognitive function in older adults. METHODS: 
      99 older adults (mean +/- SD; age 67 +/- 6 years, BMI 27.2 +/- 4.7kg/m(2), 45% female) 
      were randomly assigned to 50g/daily of whey protein isolate (WPI) or an 
      iso-caloric carbohydrate (CHO) control for 12 weeks (NCT01956994). Aortic 
      stiffness was determined as carotid-femoral pulse wave velocity (cfPWV). Aortic 
      hemodynamic load was assessed as the product of aortic systolic blood pressure 
      and heart rate (Ao SBP x HR). Cerebrovascular response to cognitive activity was 
      assessed as change in middle-cerebral artery (MCA) blood velocity pulsatility 
      index (PI) during a cognitive perturbation (Stroop task). Cognitive function was 
      assessed using a computerized neurocognitive battery. RESULTS: cfPWV increased 
      slightly in CHO and significantly decreased in WPI (p < 0.05). Ao SBP x HR was 
      unaltered in CHO but decreased significantly in WPI (p < 0.05). Although emotion 
      recognition selectively improved with WPI (p < 0.05), WPI had no effect on other 
      domains of cognitive function or MCA PI response to cognitive activity (p > 0.05 
      for all). CONCLUSIONS: Compared to CHO, WPI supplementation results in favorable 
      reductions in aortic stiffness and aortic hemodynamic load with limited effects 
      on cognitive function and cerebrovascular function in community-dwelling older 
      adults.
FAU - Lefferts, Wesley K
AU  - Lefferts WK
AUID- ORCID: 0000-0001-5957-391X
AD  - Human Performance Laboratory, Department of Exercise Science, Syracuse 
      University, Syracuse, NY 13244, USA.
FAU - Augustine, Jacqueline A
AU  - Augustine JA
AD  - Human Performance Laboratory, Department of Exercise Science, Syracuse 
      University, Syracuse, NY 13244, USA.
FAU - Spartano, Nicole L
AU  - Spartano NL
AD  - Human Performance Laboratory, Department of Exercise Science, Syracuse 
      University, Syracuse, NY 13244, USA.
FAU - Hughes, William E
AU  - Hughes WE
AD  - Human Performance Laboratory, Department of Exercise Science, Syracuse 
      University, Syracuse, NY 13244, USA.
FAU - Babcock, Matthew C
AU  - Babcock MC
AD  - Human Performance Laboratory, Department of Exercise Science, Syracuse 
      University, Syracuse, NY 13244, USA.
FAU - Heenan, Brigid K
AU  - Heenan BK
AD  - Human Performance Laboratory, Department of Exercise Science, Syracuse 
      University, Syracuse, NY 13244, USA.
FAU - Heffernan, Kevin S
AU  - Heffernan KS
AD  - Human Performance Laboratory, Department of Exercise Science, Syracuse 
      University, Syracuse, NY 13244, USA.
LA  - eng
GR  - T32 HL134634/HL/NHLBI NIH HHS/United States
GR  - P30 AG0344645/NH/NIH HHS/United States
GR  - Donated whey protein isolate and carbohydrate (Carbogain)/NOW supplements/
GR  - Dairy Research Institute 1154/Dairy Management/
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200410
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aorta/*physiopathology
MH  - *Cerebrovascular Circulation
MH  - *Cognition
MH  - Dietary Carbohydrates/administration & dosage
MH  - *Dietary Supplements
MH  - *Elasticity
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - *Independent Living
MH  - Male
MH  - Middle Aged
MH  - Nutritional Physiological Phenomena/*physiology
MH  - Whey Proteins/*administration & dosage
PMC - PMC7230701
OTO - NOTNLM
OT  - blood pressure
OT  - older adults
OT  - vascular stiffness
OT  - whey protein isolate
COIS- This study was funded by The Dairy Management Inc, (Dairy Research Institute) 
      Grant1154 (Principle Investigator Heffernan) and NIH NIA P30 AG0344645 05 
      (Project Director Heffernan). Whey protein isolate and carbohydrate (Carbogain) 
      were donated by NOW supplements (Bloomingdale IL).
EDAT- 2020/04/16 06:00
MHDA- 2021/01/12 06:00
PMCR- 2020/04/01
CRDT- 2020/04/16 06:00
PHST- 2020/03/20 00:00 [received]
PHST- 2020/04/07 00:00 [revised]
PHST- 2020/04/08 00:00 [accepted]
PHST- 2020/04/16 06:00 [entrez]
PHST- 2020/04/16 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - nu12041054 [pii]
AID - nutrients-12-01054 [pii]
AID - 10.3390/nu12041054 [doi]
PST - epublish
SO  - Nutrients. 2020 Apr 10;12(4):1054. doi: 10.3390/nu12041054.