PMID- 32291406 OWN - NLM STAT- MEDLINE DCOM- 20210618 LR - 20220202 IS - 1476-5454 (Electronic) IS - 0950-222X (Print) IS - 0950-222X (Linking) VI - 35 IP - 2 DP - 2021 Feb TI - Evaluation of the association of macular ganglion cell-inner plexiform layer thickness and myopia in Chinese young adults. PG - 393-399 LID - 10.1038/s41433-020-0847-7 [doi] AB - PURPOSE: To describe the distribution of ganglion cell-inner plexiform layer (GCIPL) thickness among Chinese young adults and report whether the decreased GCIPL thickness is associated with myopia. METHODS: In this study, we included Chinese young adults who underwent Cirrus spectral domain-optical coherence tomography (SD-OCT). SD-OCT was used to measure average and minimum GCIPL thickness, and GCIPL thickness at all sectors. Subfoveal choroidal thickness (CT), axial length (AL), and spherical equivalents (SE) were also measured. RESULTS: A total of 348 eyes were included in the analysis. Average GCIPL thickness showed a significant difference between myopes and emmetropes, with 87.89 +/- 3.65 mum for emmetropic groups and 82.65 +/- 4.96 mum for myopic groups. The GCIPL thickness was significantly thinner in myopia than in emmetropia at all locations (P < 0.05), affirming that myopia was associated with thinner GCIPL thickness (P = 0.001). The mean subfoveal CT also showed a significant difference between myopes and emmetropes, with 330.57 +/- 9.43 mum for emmetropic groups and 265.98 +/- 4.12 mum for myopic groups. GCIPL (OR 0.863, 95% CI, 0.785-0.949), AL (OR 2.499, 95% CI, 1.532-4.075) and intraocular pressure (IOP) (OR 1.250, 95% CI, 1.086-1.438) revealed significant associations with myopia. When adjusting for AL, IOP, and anterior chamber depth (ACD) in the myopia subgroup, the GCIPL thickness remained positively associated. CONCLUSIONS: In a specific Chinese young population, myopic eyes have measurably less macular GCIPL thickness than normal eyes. Decreasing GCIPL thickness may be associated with the progression of myopia. FAU - Lu, Bing AU - Lu B AD - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - National Clinical Research Center for Eye Diseases, Shanghai, China. FAU - Wang, Yimin AU - Wang Y AD - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Pengfei AU - Zhang P AD - Department of Ophthalmology, The first affiliated hospital of Wannan Medical College, Wuhu, China. FAU - Liu, Yang AU - Liu Y AD - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Jia, Huixun AU - Jia H AD - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Fenghua AU - Wang F AD - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - National Clinical Research Center for Eye Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. AD - Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China. FAU - Zhou, Minwen AU - Zhou M AD - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. zmw8008@163.com. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. zmw8008@163.com. AD - National Clinical Research Center for Eye Diseases, Shanghai, China. zmw8008@163.com. AD - Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China. zmw8008@163.com. FAU - Sun, Xiaodong AU - Sun X AD - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. xdsun@sjtu.edu.cn. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. xdsun@sjtu.edu.cn. AD - National Clinical Research Center for Eye Diseases, Shanghai, China. xdsun@sjtu.edu.cn. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. xdsun@sjtu.edu.cn. AD - Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China. xdsun@sjtu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200414 PL - England TA - Eye (Lond) JT - Eye (London, England) JID - 8703986 SB - IM MH - China/epidemiology MH - Humans MH - *Myopia MH - Retina MH - *Retinal Ganglion Cells MH - Tomography, Optical Coherence MH - Young Adult PMC - PMC8026982 COIS- The authors declare that they have no conflict of interest. EDAT- 2020/04/16 06:00 MHDA- 2021/06/22 06:00 PMCR- 2022/02/01 CRDT- 2020/04/16 06:00 PHST- 2019/10/01 00:00 [received] PHST- 2020/03/17 00:00 [accepted] PHST- 2020/02/20 00:00 [revised] PHST- 2020/04/16 06:00 [pubmed] PHST- 2021/06/22 06:00 [medline] PHST- 2020/04/16 06:00 [entrez] PHST- 2022/02/01 00:00 [pmc-release] AID - 10.1038/s41433-020-0847-7 [pii] AID - 847 [pii] AID - 10.1038/s41433-020-0847-7 [doi] PST - ppublish SO - Eye (Lond). 2021 Feb;35(2):393-399. doi: 10.1038/s41433-020-0847-7. Epub 2020 Apr 14.