PMID- 32291518
OWN - NLM
STAT- MEDLINE
DCOM- 20210127
LR  - 20220406
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 412
IP  - 15
DP  - 2020 Jun
TI  - Cytostatic compounds in sludge and sediment: extraction and determination by a 
      combination of microwave-assisted extraction and UHPLC-MS/MS.
PG  - 3639-3651
LID - 10.1007/s00216-020-02600-0 [doi]
AB  - Cytostatic compounds are an important group of micro-pollutants since they are 
      used to kill cells or stop cell division. For this reason, they are also 
      considered mutagenic. Several cytostatic compounds have been detected in hospital 
      effluents, in the influents and effluents of wastewater treatment plants and even 
      in river water. However, their detection in solid matrices is very scarce. In 
      this work, we have developed a new procedure based on microwave-assisted 
      extraction (MAE) for the extraction of cytostatic compounds from sludge and 
      sediment before determination by ultra-high-performance liquid chromatography 
      tandem mass spectrometry (UHPLC-MS/MS). To develop this procedure, we have chosen 
      a group of eight widely used cytostatic compounds and carried out a systematic 
      experimental design to optimize the extraction conditions. Under these optimal 
      conditions, the studied cytostatic compounds are extracted with good sensitivity, 
      with recoveries ranging from 65 to 122% in sludge and recoveries varying between 
      49 and 109% in sediment, with the exception of etoposide, which has a lower 
      recovery from these types of samples. The limits of detection were from 0.42 to 
      79.8 ng g(-1) in sludge and from 0.10 to 87.5 ng g(-1) in sediment. Intraday and 
      interday relative standard deviations (RSDs) were below 15% and 18%, 
      respectively, in both matrices at the tested concentrations. The total procedure 
      was applied to samples of sludge taken from the main wastewater treatment plant 
      (WWTP) of the island of Gran Canaria (Spain) and for sediment samples obtained 
      close to the marine outfalls of different wastewater treatment plants for the 
      same island. Graphical abstract.
FAU - Santana-Viera, Sergio
AU  - Santana-Viera S
AD  - Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), 
      Universidad de Las Palmas de Gran Canaria, 35017, Las Palmas de Gran Canaria, 
      Spain.
FAU - Tucek, Jozef
AU  - Tucek J
AD  - Faculty of Natural Sciences, Department of Analytical Chemistry, Comenius 
      University in Bratislava, Ilkovicova 6, 842 15, Bratislava, Slovak Republic.
FAU - Torres-Padron, Maria Esther
AU  - Torres-Padron ME
AD  - Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), 
      Universidad de Las Palmas de Gran Canaria, 35017, Las Palmas de Gran Canaria, 
      Spain.
FAU - Sosa-Ferrera, Zoraida
AU  - Sosa-Ferrera Z
AD  - Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), 
      Universidad de Las Palmas de Gran Canaria, 35017, Las Palmas de Gran Canaria, 
      Spain.
FAU - Santana-Rodriguez, Jose Juan
AU  - Santana-Rodriguez JJ
AD  - Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), 
      Universidad de Las Palmas de Gran Canaria, 35017, Las Palmas de Gran Canaria, 
      Spain. josejuan.santana@ulpgc.es.
FAU - Halko, Radoslav
AU  - Halko R
AD  - Faculty of Natural Sciences, Department of Analytical Chemistry, Comenius 
      University in Bratislava, Ilkovicova 6, 842 15, Bratislava, Slovak Republic.
LA  - eng
GR  - PhD student grant/Universidad de Las Palmas de Gran Canaria/
PT  - Journal Article
PT  - Validation Study
DEP - 20200414
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Cytostatic Agents)
RN  - 0 (Sewage)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Cytostatic Agents/*analysis/isolation & purification
MH  - Geologic Sediments/*analysis
MH  - Limit of Detection
MH  - Microwaves
MH  - Sewage/*analysis
MH  - Solid Phase Extraction/methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Water Pollutants, Chemical/*analysis/isolation & purification
OTO - NOTNLM
OT  - Digestion/microwave digestion
OT  - HPLC
OT  - Organic compounds/trace organic compounds
OT  - Pharmaceuticals
OT  - Sediments/soil
OT  - Waste/sludge
EDAT- 2020/04/16 06:00
MHDA- 2021/01/28 06:00
CRDT- 2020/04/16 06:00
PHST- 2020/01/14 00:00 [received]
PHST- 2020/03/13 00:00 [accepted]
PHST- 2020/02/27 00:00 [revised]
PHST- 2020/04/16 06:00 [pubmed]
PHST- 2021/01/28 06:00 [medline]
PHST- 2020/04/16 06:00 [entrez]
AID - 10.1007/s00216-020-02600-0 [pii]
AID - 10.1007/s00216-020-02600-0 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2020 Jun;412(15):3639-3651. doi: 10.1007/s00216-020-02600-0. 
      Epub 2020 Apr 14.