PMID- 32292331
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210809
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 14
DP  - 2020
TI  - Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by 
      Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK 
      Signaling in a Mouse Model of Alzheimer's Disease.
PG  - 62
LID - 10.3389/fncel.2020.00062 [doi]
LID - 62
AB  - Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are promising for 
      the treatment of Alzheimer's disease (AD). However, their low rate of migration 
      and survival in the brain limit their clinical applicability. This study is 
      designed to improve the therapeutic potential of hUC-MSCs by preincubating them 
      with resveratrol, a natural polyphenol capable of regulating cell destiny. 
      Herein, we demonstrate that resveratrol preincubation enhances the migration of 
      hUC-MSCs in vitro, as well as their survival and homing into the hippocampus of 
      AD mice in vivo. Moreover, resveratrol-primed MSCs were better able to inhibit 
      amyloid-beta peptide (Abeta) deposition, Tau hyperphosphorylation, and oxidative 
      stress, all while improving learning and memory. Notably, we found that hUC-MSCs 
      inhibited neuroinflammation by reacting with astrocytes and microglial cells and 
      suppressing mitogen-activated protein kinases (MAPKs), extracellular signal 
      kinases (ERK), p38 kinases (p38), and c-Jun N-terminal kinases (JNK) signaling 
      pathways in the hippocampus of AD mice. Furthermore, resveratrol pretreatment 
      enhanced these effects. Conclusively, the current study revealed that resveratrol 
      preconditioning protected hUC-MSCs against the hostile microenvironment 
      characteristic of AD and enhanced their viability and homing into the brain of AD 
      mice. The use of resveratrol-pretreated hUC-MSCs is thereby proposed to be a 
      promising therapy for AD.
CI  - Copyright (c) 2020 Wang, Wu, Ma, Xie, Liu, Yao, Zhang, Yang, Yang, Guo and Guan.
FAU - Wang, Xinxin
AU  - Wang X
AD  - Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
FAU - Wu, Junwei
AU  - Wu J
AD  - Department of Urology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
FAU - Ma, Shanshan
AU  - Ma S
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Xie, Ya
AU  - Xie Y
AD  - Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
FAU - Liu, Hongtao
AU  - Liu H
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Yao, Minghao
AU  - Yao M
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Zhang, Yanting
AU  - Zhang Y
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
FAU - Yang, Greta Luyuan
AU  - Yang GL
AD  - Stuyvesant High School, New York, NY, United States.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Guo, Ruixia
AU  - Guo R
AD  - Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
FAU - Guan, Fangxia
AU  - Guan F
AD  - School of Life Sciences, Zhengzhou University, Zhengzhou, China.
AD  - Institute of Stem Cell and Regenerative Medicine, The First Affiliated Hospital 
      of Zhengzhou University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20200327
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
RIN - Front Cell Neurosci. 2021 Jul 23;15:728508. PMID: 34366793
PMC - PMC7118399
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - MAPK
OT  - human umbilical cord-derived mesenchymal stem cells
OT  - neuroinflammation
OT  - resveratrol
EDAT- 2020/04/16 06:00
MHDA- 2020/04/16 06:01
PMCR- 2020/01/01
CRDT- 2020/04/16 06:00
PHST- 2019/11/03 00:00 [received]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/04/16 06:00 [entrez]
PHST- 2020/04/16 06:00 [pubmed]
PHST- 2020/04/16 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2020.00062 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2020 Mar 27;14:62. doi: 10.3389/fncel.2020.00062. 
      eCollection 2020.