PMID- 3229319
OWN - NLM
STAT- MEDLINE
DCOM- 19890418
LR  - 20071114
IS  - 0378-6501 (Print)
IS  - 0378-6501 (Linking)
VI  - 14
IP  - 9
DP  - 1988
TI  - A new antitumour agent, batracylin, selected by a preclinical solid tumour model.
PG  - 571-4
AB  - The antitumour efficacy of batracylin was investigated in vivo against murine 
      tumours. The drug displayed an original spectrum of activity. It was totally 
      inactive against L1210 leukaemia and B16 melanoma, while it was marginally active 
      against ascitic P388 leukaemia. However, the tumour growth of the subcutaneously 
      (s.c.) implanted colon 38 adenocarcinoma (Co 38) was completely inhibited in 
      80-90% of the mice. Therapeutic efficacy was retained upon oral administration 
      and the drug was able to induce tumour regression in the advanced Co 38 disease. 
      These data justify the selection of batracylin for toxicological studies and 
      possible clinical investigations.
FAU - Atassi, G
AU  - Atassi G
AD  - Jules Bordet Institute, Free University of Brussels, Belgium.
FAU - Dumont, P
AU  - Dumont P
FAU - Kabbe, H J
AU  - Kabbe HJ
FAU - Yoder, O
AU  - Yoder O
LA  - eng
GR  - N01-CM-57645/CM/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Drugs Exp Clin Res
JT  - Drugs under experimental and clinical research
JID - 7802135
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Quinazolines)
RN  - 67199-66-0 (batracylin)
SB  - IM
MH  - Adenocarcinoma/*drug therapy
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Colonic Neoplasms/*drug therapy
MH  - *Drug Screening Assays, Antitumor
MH  - Leukemia L1210/drug therapy
MH  - Leukemia P388/drug therapy
MH  - Melanoma, Experimental/drug therapy
MH  - Mice
MH  - Quinazolines/*therapeutic use
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Drugs Exp Clin Res. 1988;14(9):571-4.