PMID- 32293313
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 21
IP  - 1
DP  - 2020 Apr 15
TI  - Urinary monocyte chemoattractant protein 1 associated with calcium oxalate 
      crystallization in patients with primary hyperoxaluria.
PG  - 133
LID - 10.1186/s12882-020-01783-z [doi]
LID - 133
AB  - BACKGROUND: Patients with primary hyperoxaluria (PH) often develop kidney stones 
      and chronic kidney disease. Noninvasive urine markers reflective of active kidney 
      injury could be useful to gauge the effectiveness of ongoing treatments. METHODS: 
      A panel of biomarkers that reflect different nephron sites and potential 
      mechanisms of injury (clusterin, neutrophil gelatinase-associated lipocalin 
      (NGAL), 8-isoprostane (8IP), monocyte-chemoattractant protein 1(MCP-1), 
      liver-type fatty acid binding protein (L-FABP), heart-type fatty acid binding 
      protein (H-FABP), and osteopontin (OPN)) were measured in 114 urine specimens 
      from 30 PH patients over multiple visits. Generalized estimating equations were 
      used to assess associations between biomarkers and 24 h urine excretions, 
      calculated proximal tubular oxalate concentration (PTOx), and eGFR. RESULTS: Mean 
      (+/-SD) age at first visit was 19.5 +/- 16.6 years with an estimated glomerular 
      filtration rate (eGFR) of 68.4 +/- 21.0 ml/min/1.73m(2). After adjustment for age, 
      sex, and eGFR, a higher urine MCP-1 concentration and MCP-1/creatinine ratio was 
      positively associated with CaOx supersaturation (SS). Higher urine NGAL and 
      NGAL/creatinine as well as OPN and OPN/creatinine were associated with higher 
      eGFR. 8IP was negatively associated with PTOx and urinary Ox, but positively 
      associated with CaOx SS. CONCLUSION: In PH patients greater urine MCP-1 and 8IP 
      excretion might reflect ongoing collecting tubule crystallization, while greater 
      NGAL and OPN excretion may reflect preservation of kidney mass and function. CaOx 
      crystals, rather than oxalate ion may mediate oxidative stress in hyperoxaluric 
      conditions. Further studies are warranted to determine whether urine MCP-1 
      excretion predicts long term outcome or is altered in response to treatment.
FAU - Wang, Xiangling
AU  - Wang X
AD  - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo 
      Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
FAU - Bhutani, Gauri
AU  - Bhutani G
AD  - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo 
      Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
FAU - Vaughan, Lisa E
AU  - Vaughan LE
AD  - Division of Biomedical Statistics and Informatics, Department of Health Sciences 
      Research, Mayo Clinic, Rochester, MN, USA.
FAU - Enders, Felicity T
AU  - Enders FT
AD  - Division of Biomedical Statistics and Informatics, Department of Health Sciences 
      Research, Mayo Clinic, Rochester, MN, USA.
FAU - Haskic, Zejfa
AU  - Haskic Z
AD  - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo 
      Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
FAU - Milliner, Dawn
AU  - Milliner D
AD  - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo 
      Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
FAU - Lieske, John C
AU  - Lieske JC
AD  - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo 
      Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Lieske.John@mayo.edu.
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 
      Lieske.John@mayo.edu.
CN  - investigators of the Rare Kidney Stone Consortium
LA  - eng
GR  - U54 DK083908/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200415
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 106441-73-0 (Osteopontin)
RN  - 2612HC57YE (Calcium Oxalate)
SB  - IM
MH  - Adult
MH  - Biomarkers/urine
MH  - *Calcium Oxalate/metabolism/urine
MH  - *Chemokine CCL2/metabolism/urine
MH  - Crystallization
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - *Hyperoxaluria, Primary/complications/metabolism/urine
MH  - *Kidney/metabolism/pathology
MH  - *Kidney Calculi/diagnosis/etiology/metabolism
MH  - Male
MH  - Osteopontin/urine
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Renal Elimination
MH  - *Renal Insufficiency, Chronic/diagnosis/etiology/physiopathology
PMC - PMC7161151
OTO - NOTNLM
OT  - Crystallization
OT  - Glomerular filtration rate
OT  - Monocyte-chemoattractant protein 1
OT  - Primary hyperoxaluria
OT  - Renal damage
COIS- The authors declare no conflicts of interest or competing interests. This 
      research is involving human subjects.
FIR - Assimos, Dean
IR  - Assimos D
FIR - Baum, Michelle
IR  - Baum M
FIR - Somers, Michael
IR  - Somers M
FIR - Copelovitch, Lawrence
IR  - Copelovitch L
FIR - Devarajan, Prasad
IR  - Devarajan P
FIR - Goldfarb, David
IR  - Goldfarb D
FIR - Harvey, Elizabeth
IR  - Harvey E
FIR - Robinson, Lisa
IR  - Robinson L
FIR - Haley, William
IR  - Haley W
FIR - Michael, Mini
IR  - Michael M
FIR - Langman, Craig
IR  - Langman C
EDAT- 2020/04/16 06:00
MHDA- 2021/09/04 06:00
PMCR- 2020/04/15
CRDT- 2020/04/16 06:00
PHST- 2019/10/15 00:00 [received]
PHST- 2020/03/23 00:00 [accepted]
PHST- 2020/04/16 06:00 [entrez]
PHST- 2020/04/16 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
PHST- 2020/04/15 00:00 [pmc-release]
AID - 10.1186/s12882-020-01783-z [pii]
AID - 1783 [pii]
AID - 10.1186/s12882-020-01783-z [doi]
PST - epublish
SO  - BMC Nephrol. 2020 Apr 15;21(1):133. doi: 10.1186/s12882-020-01783-z.