PMID- 32293364
OWN - NLM
STAT- MEDLINE
DCOM- 20200824
LR  - 20200824
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Mar 23
TI  - Influence of benzene exposure, fat content, and their interactions on 
      erythroid-related hematologic parameters in petrochemical workers: a 
      cross-sectional study.
PG  - 382
LID - 10.1186/s12889-020-08493-z [doi]
LID - 382
AB  - BACKGROUND: Ubiquitously distributed benzene is a known hematotoxin. Increasing 
      evidence has suggested that erythroid-related hematologic parameters may be 
      sensitive to benzene exposure. Fat content, which is also closely associated with 
      erythroid-related hematologic parameters, may affect the distribution and/or 
      metabolism of benzene, and eventually benzene-induced toxicity. METHODS: To 
      explore the influence of benzene exposure, fat content, and their interactions on 
      erythroid-related hematologic parameters, we recruited 1669 petrochemical workers 
      and measured their urinary S-phenylmercapturic acid (SPMA) concentration and 
      erythroid-related hematological parameters. Indices for fat content included body 
      fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG), and 
      occurrence of fatty liver. RESULTS: The dose-response curve revealed U-shaped 
      nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular 
      hemoglobin concentration (MCHC) (P-overall < 0.001, and P-nonlinear < 0.015), as 
      well as positive linear associations and r-shaped nonlinear relationships of 
      continuous fat content indices with erythroid-related hematological parameters 
      (P-overall </=0.005). We also observed modification effects of fat content on the 
      associations between benzene exposure and erythroid-related hematological 
      parameters, with workers of lower or higher BF% and TG more sensitive to 
      benzene-induced elevation of MCHC (P(interaction) = 0.021) and benzene-induced 
      decrease of HCT (P(interaction) = 0.050), respectively. We also found that some 
      erythroid-related hematologic parameters differed between subgroups of workers 
      with different SPMA levels and fat content combination. CONCLUSIONS: Our study 
      suggested that benzene exposure, fat content, and their interactions may affect 
      erythroid-related hematological parameters in petrochemical workers in a complex 
      manner that are worthy of further investigation.
FAU - Zhang, Xue
AU  - Zhang X
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Deng, Qifei
AU  - Deng Q
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - He, Zhini
AU  - He Z
AD  - Food Safety and Health Research Center, School of Public Health, Southern Medical 
      University, Guangzhou, 510515, Guangdong, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Division of Vital Statistics and Death Surveillance, National Center for Chronic 
      and Noncommunicable Disease Control and Prevention, Chinese Center for Disease 
      Control and Prevention, Beijing, 100050, China.
FAU - Ma, Xiaoju
AU  - Ma X
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Zhang, Zhaorui
AU  - Zhang Z
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Wu, Dehua
AU  - Wu D
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Xing, Xiumei
AU  - Xing X
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Peng, Jing
AU  - Peng J
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Guo, Hongyu
AU  - Guo H
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Huang, Ming
AU  - Huang M
AD  - Guangdong Provincial Key Laboratory of Occupational Disease Prevention and 
      Treatment, Guangdong Province Hospital for Occupational Disease Prevention and 
      Treatment, Guangzhou, 510300, Guangdong, China.
FAU - Chen, Liping
AU  - Chen L
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Dang, Shanfeng
AU  - Dang S
AD  - Occupational Disease Prevention and Treatment Institute of Sinopec Maoming 
      Petrochemical Company, Maoming, 525000, Guangdong, China.
FAU - Zhu, Yanqun
AU  - Zhu Y
AD  - Occupational Disease Prevention and Treatment Institute of Sinopec Maoming 
      Petrochemical Company, Maoming, 525000, Guangdong, China.
FAU - Zhang, Zhengbao
AU  - Zhang Z
AD  - Food Safety and Health Research Center, School of Public Health, Southern Medical 
      University, Guangzhou, 510515, Guangdong, China.
FAU - Yang, Boyi
AU  - Yang B
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Wang, Hailan
AU  - Wang H
AD  - Guangdong Provincial Key Laboratory of Occupational Disease Prevention and 
      Treatment, Guangdong Province Hospital for Occupational Disease Prevention and 
      Treatment, Guangzhou, 510300, Guangdong, China.
FAU - Chen, Wen
AU  - Chen W
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
FAU - Xiao, Yongmei
AU  - Xiao Y
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China. 
      xiaoym@mail.sysu.edu.cn.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of 
      Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China. 
      xiaoym@mail.sysu.edu.cn.
LA  - eng
GR  - 81430079/key Program of the National Natural Science Foundation of China/
GR  - 81372962/regular National Natural Science Foundation of China/
GR  - 81402658/regular National Natural Science Foundation of China/
GR  - 81273099/regular National Natural Science Foundation of China/
GR  - 81602877/regular National Natural Science Foundation of China/
GR  - 2014BAI12B01/National "Twelfth Five-Year Plan" for Science & Technology/
GR  - 2016A030310163/Guangdong Province Doctor Staring Program Grant/
GR  - 18ykpy14/Young Teachers Training Program of Sun Yat-sen University/
PT  - Journal Article
DEP - 20200323
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
RN  - 0 (Biomarkers)
RN  - 0 (Hemoglobins)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 4775-80-8 (S-phenyl-N-acetylcysteine)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - J64922108F (Benzene)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/analogs & derivatives/urine
MH  - *Adipose Tissue
MH  - Adult
MH  - Benzene/metabolism/*toxicity
MH  - Biomarkers/urine
MH  - *Body Composition
MH  - Chemical Industry
MH  - Cholesterol
MH  - Cross-Sectional Studies
MH  - Disease Susceptibility
MH  - Environmental Exposure/*adverse effects/analysis
MH  - Erythrocytes
MH  - Female
MH  - Hematocrit
MH  - *Hematology
MH  - Hemoglobins
MH  - Humans
MH  - *Lipids
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/analysis
MH  - *Occupations
MH  - Triglycerides
PMC - PMC7092548
OTO - NOTNLM
OT  - Benzene exposure
OT  - Erythroid-related hematologic parameters
OT  - Fat content
OT  - Interactions
COIS- The authors declare that they have no competing interests.
EDAT- 2020/04/16 06:00
MHDA- 2020/08/25 06:00
PMCR- 2020/03/23
CRDT- 2020/04/16 06:00
PHST- 2019/10/25 00:00 [received]
PHST- 2020/03/09 00:00 [accepted]
PHST- 2020/04/16 06:00 [entrez]
PHST- 2020/04/16 06:00 [pubmed]
PHST- 2020/08/25 06:00 [medline]
PHST- 2020/03/23 00:00 [pmc-release]
AID - 10.1186/s12889-020-08493-z [pii]
AID - 8493 [pii]
AID - 10.1186/s12889-020-08493-z [doi]
PST - epublish
SO  - BMC Public Health. 2020 Mar 23;20(1):382. doi: 10.1186/s12889-020-08493-z.