PMID- 32293387
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Mar 23
TI  - Validity of EQ-5D utility index and minimal clinically important difference 
      estimation among patients with chronic obstructive pulmonary disease.
PG  - 73
LID - 10.1186/s12890-020-1116-z [doi]
LID - 73
AB  - BACKGROUND: The discriminatory ability of multi-attribute utility (MAU) measures 
      compared to condition-specific measures (CSM) in assessing health-related quality 
      of life (HRQoL) among patients with chronic obstructive pulmonary disease (COPD) 
      is an unsettled issue. This study investigated the quality of life of patients 
      with COPD with three different HRQoL instruments and examined whether they could 
      differentiate between adjacent severity groups in a statistically and clinically 
      meaningful manner. In the process, the minimal clinically important differences 
      (MCID) of the EQ-5D utility index were estimated. METHODS: Cross-sectional survey 
      data were collected from patients with mild to very severe COPD in South Korea. 
      In addition to demographic and clinical information, the following HRQoL 
      questionnaires were used: The three-level five-dimensional Euro-Quality of Life 
      tool (EQ-5D-3L), the EQ-Visual Analog Scale (EQ-VAS), and the Chronic Obstructive 
      Pulmonary Disease Assessment Test (CAT). Patients' health-related quality of life 
      was analyzed with reference to severity groups based on the Global Initiative for 
      Chronic Obstructive Lung Disease (GOLD) classification. To investigate the 
      discriminatory ability of the HRQoL instruments between COPD severity groups, 
      tests examining variance, covariance, and standardized mean difference were 
      performed. After estimating the MCID of the EQ-5D utility index using the 
      anchor-based method, we investigated whether the differences in the EQ-5D utility 
      scores between groups exceeded the clinically meaningful minimum level. RESULTS: 
      A total of 298 patients completed this study. All the quality of life scores 
      showed statistically significant differences between the GOLD severity groups. 
      The pooled MCID estimate for the EQ-5D utility index was 0.028 (range: 
      0.017-0.033). Even after adjusting for other factors affecting quality of life, 
      the EQ-5D utility index differentiated the GOLD groups well. CONCLUSIONS: We 
      conclude that the EQ-5D utility index is a valid instrument for measuring the 
      quality of life of patients with COPD, and the pooled MCID estimate for the EQ-5D 
      utility index was 0.028.
FAU - Bae, Eunmi
AU  - Bae E
AD  - College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, 30019, South 
      Korea.
FAU - Choi, Sang-Eun
AU  - Choi SE
AUID- ORCID: 0000-0003-3111-1144
AD  - College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, 30019, South 
      Korea. sechoi@korea.ac.kr.
FAU - Lee, Haeyoung
AU  - Lee H
AD  - University of Maryland School of Pharmacy, Baltimore, MD, USA.
FAU - Shin, Gyeongseon
AU  - Shin G
AD  - College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, 30019, South 
      Korea.
FAU - Kang, Daewon
AU  - Kang D
AD  - College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, 30019, South 
      Korea.
LA  - eng
GR  - NRF-2017R1A2B1003846/National Research Foundation (KR)/
PT  - Journal Article
PT  - Multicenter Study
PT  - Validation Study
DEP - 20200323
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
SB  - IM
MH  - Activities of Daily Living/psychology
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Pain Measurement/*statistics & numerical data
MH  - Pulmonary Disease, Chronic Obstructive/physiopathology/*psychology
MH  - Quality of Life/*psychology
MH  - Republic of Korea
MH  - Respiratory Function Tests
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
PMC - PMC7092534
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease
OT  - EQ-5D
OT  - Health-related quality of life
OT  - Korea
OT  - MCID
OT  - Utility
COIS- The authors declare that they have no competing interests.
EDAT- 2020/04/16 06:00
MHDA- 2021/01/26 06:00
PMCR- 2020/03/23
CRDT- 2020/04/16 06:00
PHST- 2019/01/16 00:00 [received]
PHST- 2020/03/16 00:00 [accepted]
PHST- 2020/04/16 06:00 [entrez]
PHST- 2020/04/16 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/03/23 00:00 [pmc-release]
AID - 10.1186/s12890-020-1116-z [pii]
AID - 1116 [pii]
AID - 10.1186/s12890-020-1116-z [doi]
PST - epublish
SO  - BMC Pulm Med. 2020 Mar 23;20(1):73. doi: 10.1186/s12890-020-1116-z.