PMID- 32294272
OWN - NLM
STAT- MEDLINE
DCOM- 20201020
LR  - 20231111
IS  - 1521-3765 (Electronic)
IS  - 0947-6539 (Print)
IS  - 0947-6539 (Linking)
VI  - 26
IP  - 38
DP  - 2020 Jul 8
TI  - Self-Assembled Supramolecular Hybrid Hydrogel Beads Loaded with Silver 
      Nanoparticles for Antimicrobial Applications.
PG  - 8452-8457
LID - 10.1002/chem.202001349 [doi]
AB  - This Full Paper reports the formation of silver (Ag) NPs within spatially 
      resolved two-component hydrogel beads, which combine a low-molecular-weight 
      gelator (LMWG) DBS-CONHNH(2) and a polymer gelator (PG) calcium alginate. The 
      AgNPs are formed through in situ reduction of Ag(I) , with the resulting 
      nanoparticle-loaded gels being characterised in detail. The antibacterial 
      activity of the nanocomposite gel beads was tested against two drug-resistant 
      bacterial strains, often associated with hospital-acquired infections: 
      vancomycin-resistant Enterococcus faecium (VRE) and Pseudomonas aeruginosa 
      (PA14), and the AgNP-loaded gels showed good antimicrobial properties against 
      both types of bacteria. It is suggested that the gel bead format of these 
      AgNP-loaded hybrid hydrogels makes them promising versatile materials for 
      potential applications in orthopaedics or wound healing.
CI  - (c) 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
FAU - Piras, Carmen C
AU  - Piras CC
AUID- ORCID: 0000-0002-7128-2979
AD  - Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
FAU - Mahon, Clare S
AU  - Mahon CS
AD  - Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
FAU - Smith, David K
AU  - Smith DK
AUID- ORCID: 0000-0002-9881-2714
AD  - Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
LA  - eng
GR  - EP/P03361X/1/Engineering and Physical Sciences Research Council/
GR  - 702927/Seventh Framework Programme/
PT  - Journal Article
DEP - 20200611
PL  - Germany
TA  - Chemistry
JT  - Chemistry (Weinheim an der Bergstrasse, Germany)
JID - 9513783
RN  - 0 (Alginates)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Hydrogels)
RN  - 0 (Polymers)
RN  - 3M4G523W1G (Silver)
SB  - IM
MH  - Alginates/*chemistry
MH  - Anti-Bacterial Agents/*chemistry
MH  - Anti-Infective Agents/*chemistry
MH  - Hydrogels/*chemistry
MH  - Metal Nanoparticles/*chemistry
MH  - Microbial Sensitivity Tests
MH  - Polymers/chemistry
MH  - Pseudomonas aeruginosa
MH  - Silver/*chemistry
MH  - Wound Healing
PMC - PMC7384024
OTO - NOTNLM
OT  - antimicrobial
OT  - gel
OT  - nanoparticle
OT  - self-assembly
OT  - supramolecular chemistry
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/16 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/07/27
CRDT- 2020/04/16 06:00
PHST- 2020/03/18 00:00 [received]
PHST- 2020/04/08 00:00 [revised]
PHST- 2020/04/16 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/04/16 06:00 [entrez]
PHST- 2020/07/27 00:00 [pmc-release]
AID - CHEM202001349 [pii]
AID - 10.1002/chem.202001349 [doi]
PST - ppublish
SO  - Chemistry. 2020 Jul 8;26(38):8452-8457. doi: 10.1002/chem.202001349. Epub 2020 
      Jun 11.