PMID- 32294979
OWN - NLM
STAT- MEDLINE
DCOM- 20210203
LR  - 20210203
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 8
DP  - 2020 Apr 13
TI  - Checking NEKs: Overcoming a Bottleneck in Human Diseases.
LID - 10.3390/molecules25081778 [doi]
LID - 1778
AB  - In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), 
      mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase 
      (ERK), have been linked to important human diseases, although some kinase 
      families remain neglected in terms of research, hiding their relevance to 
      therapeutic approaches. Here, a review regarding the NEK family is presented, 
      shedding light on important information related to NEKs and human diseases. NEKs 
      are a large group of homologous kinases with related functions and structures 
      that participate in several cellular processes such as the cell cycle, cell 
      division, cilia formation, and the DNA damage response. The review of the 
      literature points to the pivotal participation of NEKs in important human 
      diseases, like different types of cancer, diabetes, ciliopathies and central 
      nervous system related and inflammatory-related diseases. The different known 
      regulatory molecular mechanisms specific to each NEK are also presented, relating 
      to their involvement in different diseases. In addition, important information 
      about NEKs remains to be elucidated and is highlighted in this review, showing 
      the need for other studies and research regarding this kinase family. Therefore, 
      the NEK family represents an important group of kinases with potential 
      applications in the therapy of human diseases.
FAU - Peres de Oliveira, Andressa
AU  - Peres de Oliveira A
AD  - Instituto de Biologia, Departamento de Bioquimica e Biologia Tecidual, 
      Universidade Estadual de Campinas, Campinas, Sao Paulo 13083-862, Brazil.
FAU - Kazuo Issayama, Luidy
AU  - Kazuo Issayama L
AD  - Instituto de Biologia, Departamento de Bioquimica e Biologia Tecidual, 
      Universidade Estadual de Campinas, Campinas, Sao Paulo 13083-862, Brazil.
AD  - Faculdade de Ciencias Farmaceuticas, Universidade Estadual de Campinas, Campinas, 
      Sao Paulo 13083-871, Brazil.
FAU - Betim Pavan, Isadora Carolina
AU  - Betim Pavan IC
AD  - Instituto de Biologia, Departamento de Bioquimica e Biologia Tecidual, 
      Universidade Estadual de Campinas, Campinas, Sao Paulo 13083-862, Brazil.
AD  - Faculdade de Ciencias Farmaceuticas, Universidade Estadual de Campinas, Campinas, 
      Sao Paulo 13083-871, Brazil.
AD  - Laboratorio Multidisciplinar em Alimentos e Saude, Faculdade de Ciencias 
      Aplicadas, Universidade Estadual de Campinas, Sao Paulo 13484-350, Brazil.
FAU - Riback Silva, Fernando
AU  - Riback Silva F
AD  - Instituto de Biologia, Departamento de Bioquimica e Biologia Tecidual, 
      Universidade Estadual de Campinas, Campinas, Sao Paulo 13083-862, Brazil.
AD  - Faculdade de Ciencias Farmaceuticas, Universidade Estadual de Campinas, Campinas, 
      Sao Paulo 13083-871, Brazil.
FAU - Diniz Melo-Hanchuk, Talita
AU  - Diniz Melo-Hanchuk T
AD  - Instituto de Biologia, Departamento de Bioquimica e Biologia Tecidual, 
      Universidade Estadual de Campinas, Campinas, Sao Paulo 13083-862, Brazil.
AD  - Faculdade de Ciencias Farmaceuticas, Universidade Estadual de Campinas, Campinas, 
      Sao Paulo 13083-871, Brazil.
FAU - Moreira Simabuco, Fernando
AU  - Moreira Simabuco F
AUID- ORCID: 0000-0002-1672-9686
AD  - Laboratorio Multidisciplinar em Alimentos e Saude, Faculdade de Ciencias 
      Aplicadas, Universidade Estadual de Campinas, Sao Paulo 13484-350, Brazil.
FAU - Kobarg, Jorg
AU  - Kobarg J
AUID- ORCID: 0000-0002-9419-0145
AD  - Faculdade de Ciencias Farmaceuticas, Universidade Estadual de Campinas, Campinas, 
      Sao Paulo 13083-871, Brazil.
LA  - eng
GR  - 2017/03489-1/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/
GR  - 2014/15982-6/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/
GR  - 2008/57906-3/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/
GR  - 2018/14818-9/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/
GR  - 20131776/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
GR  - 573913/2008-0/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
PT  - Journal Article
PT  - Review
DEP - 20200413
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.11.1 (NIMA-Related Kinases)
SB  - IM
MH  - Animals
MH  - Cell Cycle Proteins/metabolism
MH  - Central Nervous System Diseases/*enzymology/metabolism
MH  - Ciliopathies/*enzymology/metabolism
MH  - Diabetes Mellitus/*enzymology/metabolism
MH  - Humans
MH  - Inflammation/*enzymology/metabolism
MH  - NIMA-Related Kinases/antagonists & inhibitors/genetics/*metabolism
MH  - Neoplasms/*enzymology/metabolism
MH  - Phosphorylation
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Signal Transduction/genetics
PMC - PMC7221840
OTO - NOTNLM
OT  - NEKs
OT  - cancer
OT  - disorders
COIS- All authors declared that they have no conflict of interest in this study.
EDAT- 2020/04/17 06:00
MHDA- 2021/02/04 06:00
PMCR- 2020/04/13
CRDT- 2020/04/17 06:00
PHST- 2020/03/10 00:00 [received]
PHST- 2020/04/02 00:00 [revised]
PHST- 2020/04/09 00:00 [accepted]
PHST- 2020/04/17 06:00 [entrez]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/02/04 06:00 [medline]
PHST- 2020/04/13 00:00 [pmc-release]
AID - molecules25081778 [pii]
AID - molecules-25-01778 [pii]
AID - 10.3390/molecules25081778 [doi]
PST - epublish
SO  - Molecules. 2020 Apr 13;25(8):1778. doi: 10.3390/molecules25081778.