PMID- 32296634
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 10
DP  - 2020
TI  - PI(3,4)P2 Signaling in Cancer and Metabolism.
PG  - 360
LID - 10.3389/fonc.2020.00360 [doi]
LID - 360
AB  - The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT 
      and mammalian target of rapamycin (mTOR) are central regulators of glycolysis, 
      cancer metabolism, and cancer cell proliferation. At the molecular level, PI3K 
      signaling involves the generation of the second messenger lipids 
      phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol 
      3,4-bisphosphate [PI(3,4)P2]. There is increasing evidence that PI(3,4)P2 is not 
      only the waste product for the removal of PI(3,4,5)P3 but can also act as a 
      signaling molecule. The selective cellular functions for PI(3,4)P2 independent of 
      PI(3,4,5)P3 have been recently described, including clathrin-mediated endocytosis 
      and mTOR regulation. However, the specific spatiotemporal dynamics and signaling 
      role of PI3K minor lipid messenger PI(3,4)P2 are not well-understood. This review 
      aims at highlighting the biological functions of this lipid downstream of 
      phosphoinositide kinases and phosphatases and its implication in cancer 
      metabolism.
CI  - Copyright (c) 2020 Gozzelino, De Santis, Gulluni, Hirsch and Martini.
FAU - Gozzelino, Luca
AU  - Gozzelino L
AD  - Department of Molecular Biotechnology and Health Sciences, University of Torino, 
      Turin, Italy.
FAU - De Santis, Maria Chiara
AU  - De Santis MC
AD  - Department of Molecular Biotechnology and Health Sciences, University of Torino, 
      Turin, Italy.
FAU - Gulluni, Federico
AU  - Gulluni F
AD  - Department of Molecular Biotechnology and Health Sciences, University of Torino, 
      Turin, Italy.
FAU - Hirsch, Emilio
AU  - Hirsch E
AD  - Department of Molecular Biotechnology and Health Sciences, University of Torino, 
      Turin, Italy.
FAU - Martini, Miriam
AU  - Martini M
AD  - Department of Molecular Biotechnology and Health Sciences, University of Torino, 
      Turin, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200331
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC7136497
OTO - NOTNLM
OT  - AKT
OT  - INPP4
OT  - PI3K
OT  - PTEN
OT  - cancer biology
OT  - cancer metabolism
OT  - phosphatases
OT  - phosphoinositide
EDAT- 2020/04/17 06:00
MHDA- 2020/04/17 06:01
PMCR- 2020/01/01
CRDT- 2020/04/17 06:00
PHST- 2019/10/30 00:00 [received]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/04/17 06:00 [entrez]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2020/04/17 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2020.00360 [doi]
PST - epublish
SO  - Front Oncol. 2020 Mar 31;10:360. doi: 10.3389/fonc.2020.00360. eCollection 2020.