PMID- 32297116
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20210106
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 28
IP  - 1
DP  - 2021 Jan
TI  - Chronic depression-like phenotype in male offspring mice following perinatal 
      exposure to naturally contaminated eels with a mixture of organic and inorganic 
      pollutants.
PG  - 156-165
LID - 10.1007/s11356-020-08799-w [doi]
AB  - Previously, we demonstrated that maternal exposure to high, intermediate, or 
      lowly contaminated European eels with a mixture of chemicals, during pregnancy 
      and lactation, resulted in adult despair-like behavior, selectively in male 
      offspring mice. Here, we investigate if depression-like behavior in offspring 
      males was transient or permanent by monitoring immobility behavior, a measure of 
      behavioral despair, at three distinct stages of life, including young adult 
      (post-natal day (PND) 55), mature adult (PND 200) and middle (PNDs 335-336) age, 
      in the forced swimming (FST) and the tail suspension (TST) tests. Oxidative 
      stress markers including malondialdehyde (MDA) levels and superoxide dismutase 
      (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were evaluated 
      in the hippocampus, prefrontal cortex, and cerebellum of middle-aged animals. 
      Findings showed a significant enhancement of immobility behavior in the TST 
      performed at young adult age (all p < 0.05) in the FST carried out at mature 
      adult age (all p < 0.001) and in both behavioral tests realized at middle age 
      (all p < 0.05, except one p = 0.06) in mice perinatally exposed to eels compared 
      with non-exposed controls. Antioxidant-related enzyme activities, including SOD 
      and CAT, were only elevated in the hippocampus of middle-aged males perinatally 
      exposed to the two more polluted eels (all p < 0.05). Further, lipid 
      peroxidation, assessed by MDA levels, was not found to be differentially 
      regulated in the selected areas of middle-aged brains of exposed mice (all 
      p > 0.05). Collectively, this suggested limited oxidative metabolism disturbances 
      in middle-aged brains exposed to eels. In summary, our results highlighted that 
      offspring males perinatally exposed to naturally contaminated reared and river 
      eels with persistent organic pollutants (POPs) and heavy metals displayed chronic 
      depression-like phenotype. As extrapolation of data to humans should be done with 
      precaution, retrospective and prospective epidemiological studies are needed to 
      clarify this potential relationship, stressed in our animal model, between 
      maternal polluted fish consumption and chronically low mood in offspring.
FAU - Dridi, Imen
AU  - Dridi I
AD  - LCOMS/Neurotoxicologie Alimentaire et Bioactivite, Universite de Lorraine, 57000, 
      Metz, France.
FAU - Soulimani, Rachid
AU  - Soulimani R
AD  - LCOMS/Neurotoxicologie Alimentaire et Bioactivite, Universite de Lorraine, 57000, 
      Metz, France.
FAU - Bouayed, Jaouad
AU  - Bouayed J
AD  - LCOMS/Neurotoxicologie Alimentaire et Bioactivite, Universite de Lorraine, 57000, 
      Metz, France. jaouad.bouayed@univ-lorraine.fr.
LA  - eng
GR  - ANR-11-CESA-000/Agence Nationale de la Recherche/
PT  - Journal Article
DEP - 20200416
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Animals
MH  - *Depression/chemically induced
MH  - Eels
MH  - *Environmental Pollutants
MH  - Male
MH  - Mice
MH  - Oxidative Stress
MH  - Phenotype
MH  - Prospective Studies
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Chronic depression-related behavior
OT  - Early-life exposure
OT  - Heavy metals
OT  - POPs
OT  - Permanent effects
OT  - Polluted fish
EDAT- 2020/04/17 06:00
MHDA- 2021/01/07 06:00
CRDT- 2020/04/17 06:00
PHST- 2019/11/26 00:00 [received]
PHST- 2020/04/06 00:00 [accepted]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2020/04/17 06:00 [entrez]
AID - 10.1007/s11356-020-08799-w [pii]
AID - 10.1007/s11356-020-08799-w [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2021 Jan;28(1):156-165. doi: 
      10.1007/s11356-020-08799-w. Epub 2020 Apr 16.