PMID- 32297262
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20231103
IS  - 1878-7649 (Print)
IS  - 1878-7657 (Electronic)
IS  - 1878-7649 (Linking)
VI  - 11
IP  - 3
DP  - 2020 Jun
TI  - The relationship between malnutrition risk and inflammatory biomarkers in 
      outpatient geriatric population.
PG  - 383-391
LID - 10.1007/s41999-020-00303-4 [doi]
AB  - PURPOSE: Malnutrition is an underestimated, but significant problem among older 
      persons. It is described as a consequence of genetic and environmental factors, 
      lack of physical activity, and co-morbidities. However, a key role of a 
      geriatrician is to further explore the multidimensional complexity of this issue. 
      The aim of this study was to identify the relationship between nutritional status 
      and different factors, particularly focusing on inflammatory biomarkers. METHODS: 
      Nutritional status was assessed using Mini-Nutritional-Assessment with a score 
      below 24 (out of 30) defined as malnutrition. Different serum biomarkers of 
      inflammation were measured, such as High-Sensitivity-C-Reactive-Protein (hsCRP), 
      Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-18(IL-18), 
      osteoprotegerin(OPG), and Soluble-Receptor-For-TNF-alfa(sTNFRII). Medical 
      history, mental status (Mini-Mental-State-Examination, 
      Geriatric-Depression-Scale) and activities of daily living (using 
      Instrumental-Activities-of-Daily-Living-Scale) were used in the evaluation. The 
      relationship between nutritional status and the factors listed was assessed. 
      RESULTS: The mean age of 76 examined persons (40.8% female) from the outpatient 
      clinic was 71 years. Malnutrition risk was recognized in 29%. The following 
      factors significant in univariate regression were used in stepwise regression 
      analysis: age, sex, mental status (MMSE, GDS), valve disease, number of diseases, 
      IADL. Stepwise regression revealed that the risk of malnutrition was increased by 
      the presence of valve disease, number of diseases, and female sex. Factors that 
      increased the risk of malnutrition were: logsTNFRII (OR = 3.09; 95% CI 
      1.07-8.96), IL-8 (OR = 1.09; 95% CI 1.00-1.18), and OPG (OR = 1.27; 95% CI 
      1.02-1.57). Risk of malnutrition was negatively associated with Il-18(OR = 0.995; 
      95% CI 0.991-0.999). CONCLUSIONS: Chronic inflammation and immunologic process 
      are likely contributors to the complex etiopathogenesis of malnutrition in older 
      persons.
FAU - Fatyga, Paulina
AU  - Fatyga P
AD  - Department of Toxicology and Environmental Diseases, Jagiellonian University 
      Medical College, Krakow, Poland.
AD  - University Hospital, Krakow, Poland.
FAU - Pac, Agnieszka
AU  - Pac A
AD  - Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical 
      College, Krakow, Poland.
FAU - Fedyk-Lukasik, Malgorzata
AU  - Fedyk-Lukasik M
AD  - Department of Internal Medicine and Gerontology, Jagiellonian University Medical 
      College, 2 Jakubowskiego Str., 30-688, Krakow, Poland.
AD  - University Hospital, Krakow, Poland.
FAU - Grodzicki, Tomasz
AU  - Grodzicki T
AD  - Department of Internal Medicine and Gerontology, Jagiellonian University Medical 
      College, 2 Jakubowskiego Str., 30-688, Krakow, Poland.
AD  - University Hospital, Krakow, Poland.
FAU - Skalska, Anna
AU  - Skalska A
AUID- ORCID: 0000-0001-5560-3632
AD  - Department of Internal Medicine and Gerontology, Jagiellonian University Medical 
      College, 2 Jakubowskiego Str., 30-688, Krakow, Poland. anna.skalska@uj.edu.pl.
AD  - University Hospital, Krakow, Poland. anna.skalska@uj.edu.pl.
LA  - eng
GR  - K/ZDS/004 507/Uniwersytet Jagiellonski Collegium Medicum/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200306
PL  - Switzerland
TA  - Eur Geriatr Med
JT  - European geriatric medicine
JID - 101533694
RN  - 0 (Biomarkers)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers
MH  - Female
MH  - Geriatric Assessment
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Malnutrition/diagnosis
MH  - *Outpatients
PMC - PMC7280354
OTO - NOTNLM
OT  - Inflammatory biomarkers
OT  - MNA
OT  - Malnutrition risk
OT  - Older persons
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/04/17 06:00
MHDA- 2021/08/19 06:00
PMCR- 2020/03/06
CRDT- 2020/04/17 06:00
PHST- 2019/11/07 00:00 [received]
PHST- 2020/02/19 00:00 [accepted]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/04/17 06:00 [entrez]
PHST- 2020/03/06 00:00 [pmc-release]
AID - 10.1007/s41999-020-00303-4 [pii]
AID - 303 [pii]
AID - 10.1007/s41999-020-00303-4 [doi]
PST - ppublish
SO  - Eur Geriatr Med. 2020 Jun;11(3):383-391. doi: 10.1007/s41999-020-00303-4. Epub 
      2020 Mar 6.