PMID- 32297453
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1524-4741 (Electronic)
IS  - 1075-122X (Linking)
VI  - 26
IP  - 9
DP  - 2020 Sep
TI  - Acute toxicities after proton beam therapy following breast-conserving surgery 
      for breast cancer: Multi-institutional prospective PCG registry analysis.
PG  - 1760-1764
LID - 10.1111/tbj.13812 [doi]
AB  - We investigated adverse events (AEs) and clinical outcomes for proton beam 
      therapy (PBT) after breast-conserving surgery (BCS) for breast cancer. From 2012 
      to 2016, 82 patients received PBT in the prospective multi-institutional Proton 
      Collaborative Group registry. AEs were recorded prospectively at each 
      institution. Median follow-up was 8.1 months. Median dose was 50.4 Gy in 28 
      fractions. Most patients received a lumpectomy bed boost (90%) and regional nodal 
      irradiation (RNI)(83%). Six patients (7.3%) experienced grade 3 AEs (5 with 
      dermatitis, 5 with breast pain). Body mass index (BMI) was associated with grade 
      3 dermatitis (P = .015). Fifty-eight patients (70.7%) experienced grade >/=2 
      dermatitis. PBT including RNI after BCS is well-tolerated. Elevated BMI is 
      associated with grade 3 dermatitis.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Thorpe, Cameron S
AU  - Thorpe CS
AUID- ORCID: 0000-0003-0564-6540
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.
FAU - Niska, Joshua R
AU  - Niska JR
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.
FAU - Anderson, Justin D
AU  - Anderson JD
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.
FAU - Girardo, Marlene E
AU  - Girardo ME
AD  - Health Sciences Research, Division of Biostatistics, Mayo Clinic, Scottsdale, 
      Arizona.
FAU - McGee, Lisa A
AU  - McGee LA
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.
FAU - Hartsell, William F
AU  - Hartsell WF
AD  - Northwestern Medicine Chicago Proton Center, Warrenville, Illinois.
FAU - Larson, Gary L
AU  - Larson GL
AD  - ProCure Proton Therapy Center, Oklahoma City, Oklahoma.
FAU - Tsai, Henry K
AU  - Tsai HK
AD  - ProCure Proton Therapy Center, Somerset, New Jersey.
FAU - Rossi, Carl J
AU  - Rossi CJ
AD  - Scripps Proton Therapy Center, San Diego, California.
FAU - Rosen, Lane R
AU  - Rosen LR
AD  - Willis-Knighton Proton Therapy Center, Shreveport, Louisiana.
FAU - Vargas, Carlos E
AU  - Vargas CE
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.
LA  - eng
PT  - Journal Article
DEP - 20200415
PL  - United States
TA  - Breast J
JT  - The breast journal
JID - 9505539
SB  - IM
MH  - *Breast Neoplasms/radiotherapy/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Mastectomy, Segmental
MH  - Prospective Studies
MH  - *Proton Therapy/adverse effects
MH  - Registries
OTO - NOTNLM
OT  - breast cancer
OT  - breast-conserving therapy
OT  - proton beam therapy
OT  - radiation
OT  - radiation dermatitis
EDAT- 2020/04/17 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/04/17 06:00
PHST- 2019/12/27 00:00 [received]
PHST- 2020/02/26 00:00 [revised]
PHST- 2020/02/27 00:00 [accepted]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/04/17 06:00 [entrez]
AID - 10.1111/tbj.13812 [doi]
PST - ppublish
SO  - Breast J. 2020 Sep;26(9):1760-1764. doi: 10.1111/tbj.13812. Epub 2020 Apr 15.