PMID- 32297471
OWN - NLM
STAT- MEDLINE
DCOM- 20210608
LR  - 20210608
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 23
IP  - 7
DP  - 2020 Jul
TI  - Distinct HLA and non-HLA associations in different subtypes of ANCA-associated 
      vasculitides in North India.
PG  - 958-965
LID - 10.1111/1756-185X.13837 [doi]
AB  - AIM: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is an 
      autoimmune disease characterized by necrotizing small vessel vasculitis that can 
      affect various organs and present multiple symptoms. Susceptibility to AAV is 
      multifactorial and most likely caused by an amalgamation of genetic and 
      environmental factors. The aim of the present study was to explore the 
      distribution of human leukocyte antigen (HLA)-DRB1/DQB1, protein tyrosine 
      phosphatase non-receptor type 22 (PTPN22) and cytotoxic T-Lymphocyte-associated 
      protein 4 (CTLA-4) polymorphisms in North Indian AAV patients and their 
      associations with clinical and pathological characteristics associated with the 
      disease. METHODS: A total of 150 AAV patients and 150 healthy controls were 
      recruited. The clinical classification showed 128 as granulomatosis with 
      polyangiitis (GPA) and 21 as microscopic polyangiitis. Only 1 case of 
      eosinophilic granulomatosis with polyangiitis was encountered, which was excluded 
      from analysis. HLA-DRB1/DQB1 alleles were determined by polymerase chain 
      reaction-sequence-specific primer (PCR-SSP) method and single nucleotide variant 
      genotyping for CTLA-4 and PTPN22 was done by simple probe-based SNP arrays. 
      RESULTS: A significant predispositional association of DRB1*03 and DQB1*02 
      alleles, were confirmed in proteinase 3 (PR3)-AAV patients, whereas DRB1*10, 
      DRB1*14 and DQB1*05 were protective alleles in AAV, PR3-AAV and GPA patients. GG 
      genotype of CTLA-4 + 49A/G was increased in patients as compared to controls and 
      showed an association with AAV, PR3-AAV and GPA patients. CONCLUSION: The study 
      indicated strong genetic associations were linked with PR3 antineutrophil 
      cytoplasmic antibody specificity and it appears that PR3-AAV and MPO-AAV have 
      distinct genetic backgrounds.
CI  - (c) 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Singh, Jagdeep
AU  - Singh J
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Sharma, Aman
AU  - Sharma A
AUID- ORCID: 0000-0003-0813-1243
AD  - Department of Internal Medicine, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Rani, Lekha
AU  - Rani L
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Kaur, Navchetan
AU  - Kaur N
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Anand, Shashi
AU  - Anand S
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Saikia, Biman
AU  - Saikia B
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Jha, Saket
AU  - Jha S
AD  - Department of Internal Medicine, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Nada, Ritambhra
AU  - Nada R
AD  - Department of Histopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Minz, Ranjana Walker
AU  - Minz RW
AUID- ORCID: 0000-0003-1304-542X
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
LA  - eng
GR  - 61/4/2009-BMS/Indian Council of Medical Research/
PT  - Comparative Study
PT  - Journal Article
DEP - 20200416
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - EC 1.11.1.7 (MPO protein, human)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 3.1.3.48 (PTPN22 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22)
RN  - EC 3.4.21.76 (Myeloblastin)
SB  - IM
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/diagnosis/*genetics/immunology
MH  - Antibodies, Antineutrophil Cytoplasmic/blood
MH  - CTLA-4 Antigen/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Myeloblastin/immunology
MH  - Peroxidase/immunology
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 22/*genetics
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - granulomatosis with polyangiitis
OT  - microscopic polyangiitis
OT  - myeloperoxidase
OT  - proteinase 3
EDAT- 2020/04/17 06:00
MHDA- 2021/06/09 06:00
CRDT- 2020/04/17 06:00
PHST- 2019/11/22 00:00 [received]
PHST- 2020/02/07 00:00 [revised]
PHST- 2020/03/22 00:00 [accepted]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/06/09 06:00 [medline]
PHST- 2020/04/17 06:00 [entrez]
AID - 10.1111/1756-185X.13837 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2020 Jul;23(7):958-965. doi: 10.1111/1756-185X.13837. Epub 2020 
      Apr 16.