PMID- 32297559
OWN - NLM
STAT- MEDLINE
DCOM- 20210129
LR  - 20210129
IS  - 1759-9873 (Electronic)
IS  - 0964-5284 (Linking)
VI  - 38
IP  - 5
DP  - 2020 Oct
TI  - Electroacupuncture combined with acarbose improves insulin sensitivity via 
      peroxisome proliferator-activated receptor gamma activation and produces a stronger 
      glucose-lowering effect than acarbose alone in a rat model of steroid-induced 
      insulin resistance.
PG  - 335-342
LID - 10.1177/0964528419901135 [doi]
AB  - BACKGROUND: Previous studies have reported that electroacupuncture (EA) induces a 
      glucose-lowering effect by improving insulin resistance (IR) and reduces plasma 
      free fatty acid (FFA) levels in rats with steroid-induced insulin resistance 
      (SIIR). In addition, EA can activate cholinergic nerves and stimulate endogenous 
      opioid peptides to lower plasma glucose in streptozotocin-induced hyperglycemic 
      rats. The aim of this study was to investigate the glucose-lowering effects of 
      15 Hz EA at bilateral ST36 in combination with acarbose (ACA). We hypothesized 
      that EA combined with ACA would produce a stronger glucose-lowering effect than 
      ACA alone. METHODS: In this study, normal Wistar rats and SIIR rats were randomly 
      divided into two groups: ACA and ACA + EA. To explore the potential mechanisms 
      underlying the glucose-lowering effect, plasma FFA/insulin and insulin 
      transduction signal pathway proteins were assayed. RESULTS: Combined ACA + EA 
      treatment had a greater glucose-lowering effect than ACA alone in normal Wistar 
      rats (-45% +/- 3% vs -19% +/- 3%, p < 0.001) and SIIR model rats (-43% +/- 2% vs 
      -16% +/- 6%, p < 0.001). A significant reduction in plasma FFA levels, improvement 
      in homeostatic model assessment of IR (HOMA-IR) index (-48.9% +/- 4.0%, p < 0.001) 
      and insulin sensitivity index (102% +/- 16.9%, p < 0.001), and significant 
      increases in insulin receptor substrate 1, glucose transporter 4, and peroxisome 
      proliferator-activated receptor gamma protein expressions in skeletal muscle, were 
      also observed in the ACA + EA group of SIIR rats. CONCLUSION: Combined EA and ACA 
      therapy had a greater glucose-lowering effect than ACA monotherapy; this combined 
      therapy could be more effective at improving IR in SIIR rats, which may be 
      related to a reduction in plasma FFA levels and an elevation of insulin signaling 
      proteins. Whether this combined therapy has an effect in type 2 diabetes mellitus 
      (T2DM) patients still needs to be explored.
FAU - Chung, Yuan-Chiang
AU  - Chung YC
AD  - Department of Surgery, Cheng Ching Hospital, Taichung City.
AD  - Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 
      Dacun.
FAU - Chen, Ying-I
AU  - Chen YI
AD  - Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 
      Dacun.
FAU - Lin, Chih-Ming
AU  - Lin CM
AD  - Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 
      Dacun.
AD  - Department of Neurology, Changhua Christian Hospital, Changhua.
FAU - Chang, Su-Wei
AU  - Chang SW
AD  - Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 
      Dacun.
FAU - Hsu, Tai-Hao
AU  - Hsu TH
AD  - Department of Food Science and Biotechnology, Da-Yeh University, Dacun.
FAU - Ho, Wai-Jane
AU  - Ho WJ
AD  - Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 
      Dacun.
FAU - Lin, Jaug-Geng
AU  - Lin JG
AD  - School of Chinese Medicine, China Medical University, Taichung City.
FAU - Chang, Shih-Liang
AU  - Chang SL
AD  - Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 
      Dacun.
AD  - School of Chinese Medicine, China Medical University, Taichung City.
AD  - College of Biotechnology and Bioresource, Da-Yeh University, Changhua.
FAU - Tzeng, Chung-Yuh
AU  - Tzeng CY
AD  - Department of Medicinal Botanicals and Health Applications, Da-Yeh University, 
      Dacun.
AD  - Department of Orthopedics, Taichung Veterans General Hospital, Taichung City.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200416
PL  - England
TA  - Acupunct Med
JT  - Acupuncture in medicine : journal of the British Medical Acupuncture Society
JID - 9304117
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Insulin)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (PPAR gamma)
RN  - 0 (Steroids)
RN  - T58MSI464G (Acarbose)
SB  - IM
MH  - Acarbose/*administration & dosage
MH  - Animals
MH  - Combined Modality Therapy
MH  - *Electroacupuncture
MH  - Glucose Transporter Type 4/genetics/metabolism
MH  - Humans
MH  - Hyperglycemia/etiology/genetics/metabolism/*therapy
MH  - Insulin/metabolism
MH  - Insulin Receptor Substrate Proteins/genetics/metabolism
MH  - *Insulin Resistance
MH  - Male
MH  - Muscle, Skeletal/drug effects/metabolism
MH  - PPAR gamma/genetics/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Steroids/*adverse effects
OTO - NOTNLM
OT  - acarbose
OT  - electroacupuncture
OT  - free fatty acid
OT  - insulin
OT  - signal transduction
OT  - steroid-induced insulin resistance
EDAT- 2020/04/17 06:00
MHDA- 2021/01/30 06:00
CRDT- 2020/04/17 06:00
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/01/30 06:00 [medline]
PHST- 2020/04/17 06:00 [entrez]
AID - 10.1177/0964528419901135 [doi]
PST - ppublish
SO  - Acupunct Med. 2020 Oct;38(5):335-342. doi: 10.1177/0964528419901135. Epub 2020 
      Apr 16.