PMID- 32297641
OWN - NLM
STAT- MEDLINE
DCOM- 20200626
LR  - 20200626
IS  - 1465-3621 (Electronic)
IS  - 0368-2811 (Print)
IS  - 0368-2811 (Linking)
VI  - 50
IP  - 4
DP  - 2020 Apr 7
TI  - The prognostic role of c-MYC amplification in schistosomiasis-associated 
      colorectal cancer.
PG  - 446-455
LID - 10.1093/jjco/hyz210 [doi]
AB  - OBJECTIVE: The purpose of this study was to explore the prognostic role of c-MYC 
      amplification in colorectal cancer, particularly in schistosomiasis-associated 
      colorectal cancer. METHODS: Three hundred and fifty four cases of colorectal 
      cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan 
      University, were retrospectively analyzed in a tissue microarray (TMA) format, 
      with fluorescence in situ hybridization (FISH) assay and immunohistochemistry 
      (IHC). RESULTS: c-MYC gene amplification was found in 14.1% (50 out of 354) of 
      patients with colorectal cancer and was correlated with old age (P = 0.028), 
      positive lymph node metastasis (P = 0.004) and advanced stage tumors (P = 0.002). 
      The overexpression of c-MYC was closely associated with the amplification status 
      (P = 0.023). Kaplan-Meier survival curves for overall survival (OS) showed a 
      statistically significant difference for patients with c-MYC amplification in 
      full cohort of colorectal cancer, stage III-IV set and patients with lymph node 
      metastasis (P = 0.002, 0.034, 0.012, respectively). Further analysis found c-MYC 
      amplification associated with poorer survival in the subgroup of colorectal 
      cancer with schistosomiasis (CRC-S, P < 0.001), but not in colorectal cancer 
      without schistosomiasis (CRC-NS, P = 0.155). By multivariate analysis, c-MYC 
      amplification was an independent poor-prognostic factor in CRC-S set (P = 0.046). 
      CONCLUSIONS: Our study firstly found c-MYC amplification could predict poor 
      prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal 
      cancer without schistosomiasis.
CI  - (c) The Author(s) 2020. Published by Oxford University Press.
FAU - Pan, Weiyu
AU  - Pan W
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Wang, Weixia
AU  - Wang W
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Huang, Jie
AU  - Huang J
AD  - Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Lu, Kui
AU  - Lu K
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Huang, Sinian
AU  - Huang S
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Jiang, Dongxian
AU  - Jiang D
AD  - Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Bu, Dacheng
AU  - Bu D
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Jing, Hongyan
AU  - Jing H
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Yao, Junxia
AU  - Yao J
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Hou, Yingyong
AU  - Hou Y
AD  - Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Colorectal Neoplasms/*genetics/*parasitology/pathology
MH  - Female
MH  - *Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kaplan-Meier Estimate
MH  - Lymphatic Metastasis/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Retrospective Studies
MH  - Schistosomiasis/*genetics
PMC - PMC7160914
OTO - NOTNLM
OT  - Schistosoma japonicum
OT  - c-MYC
OT  - colorectal cancer
OT  - gene amplification
OT  - prognosis
EDAT- 2020/04/17 06:00
MHDA- 2020/06/27 06:00
PMCR- 2020/01/23
CRDT- 2020/04/17 06:00
PHST- 2019/07/31 00:00 [received]
PHST- 2019/12/15 00:00 [revised]
PHST- 2019/12/20 00:00 [accepted]
PHST- 2020/04/17 06:00 [entrez]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2020/06/27 06:00 [medline]
PHST- 2020/01/23 00:00 [pmc-release]
AID - 5714708 [pii]
AID - hyz210 [pii]
AID - 10.1093/jjco/hyz210 [doi]
PST - ppublish
SO  - Jpn J Clin Oncol. 2020 Apr 7;50(4):446-455. doi: 10.1093/jjco/hyz210.