PMID- 32298596
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1556-8342 (Electronic)
IS  - 1556-8253 (Print)
IS  - 1556-8253 (Linking)
VI  - 15
IP  - 5
DP  - 2020 May
TI  - Growth, Body Composition, and Neurodevelopmental Outcomes at 2 Years Among 
      Preterm Infants Fed an Exclusive Human Milk Diet in the Neonatal Intensive Care 
      Unit: A Pilot Study.
PG  - 304-311
LID - 10.1089/bfm.2019.0210 [doi]
AB  - Background: Long-term outcomes of preterm infants fed an exclusive human 
      milk-based (EHM) diet using a donor human milk-based fortifier are not well 
      defined. Materials and Methods: Infants </=1,250 g birth weight (BW) were studied 
      prospectively at two outpatient visits: 12-15 and 18-22 months corrected age 
      (CA). Dual-energy X-ray absorptiometry and Bayley Scales of Infant and Toddler 
      Development III (BSID-III) were performed at 18-22 months CA. Results: In this 
      pilot study, 51 preterm infants (gestational age 27.8 +/- 2.6 weeks and BW 
      893 +/- 204 g) were evaluated. While anthropometric z-scores were significantly 
      lower at discharge compared with birth, z-scores returned to birth levels by 
      12-15 months CA (length and head circumference [HC]) and 18-22 months CA 
      (weight). Body composition at 2 years of age was similar to term-matched 
      controls. Inpatient growth was significantly correlated with bone density, lean 
      mass (LM), and fat-free mass at 18-22 months CA. Increased mother's own milk 
      (MOM) was significantly correlated with decreased fat mass indices. BSID-III 
      showed that 0% of cognitive composite scores were <70. Conclusions: In addition 
      to returning to BW, length, and HC z-scores by 2 years of age, body composition 
      analysis revealed that increase in body size was appropriate as reflected by LM 
      and bone density similar to matched term controls without an increase in fat 
      mass. No child had severe cognitive developmental delay using a cutoff score of 
      70. Inpatient growth and increased receipt of MOM correlated with favorable 
      growth and body composition outcomes. Positive outcomes as shown in this study to 
      confirm postdischarge safety of an EHM diet during hospitalization.
FAU - Bergner, Erynn M
AU  - Bergner EM
AD  - Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, 
      Texas Children's Hospital, Houston, Texas, USA.
AD  - Department of Pediatrics, Section of Neonatology, University of Oklahoma Health 
      Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Shypailo, Roman
AU  - Shypailo R
AD  - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor 
      College of Medicine, Houston, Texas, USA.
FAU - Visuthranukul, Chonnikant
AU  - Visuthranukul C
AD  - Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, 
      Texas Children's Hospital, Houston, Texas, USA.
AD  - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor 
      College of Medicine, Houston, Texas, USA.
AD  - Department of Pediatrics, Section of Nutrition, King Chulalongkorn Memorial 
      Hospital, The Thai Red Cross Society, Bangkok, Thailand.
AD  - Pediatric Nutrition STAR, Department of Pediatrics, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
FAU - Hagan, Joseph
AU  - Hagan J
AD  - Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, 
      Texas Children's Hospital, Houston, Texas, USA.
FAU - O'Donnell, Andrea R
AU  - O'Donnell AR
AD  - Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, 
      Texas Children's Hospital, Houston, Texas, USA.
FAU - Hawthorne, Keli M
AU  - Hawthorne KM
AD  - Department of Pediatrics, Dell Medical School, Dell Pediatric Research Institute, 
      University of Texas at Austin, Austin, Texas, USA.
FAU - Abrams, Steven A
AU  - Abrams SA
AD  - Department of Pediatrics, Dell Medical School, Dell Pediatric Research Institute, 
      University of Texas at Austin, Austin, Texas, USA.
FAU - Hair, Amy B
AU  - Hair AB
AD  - Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, 
      Texas Children's Hospital, Houston, Texas, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200416
PL  - United States
TA  - Breastfeed Med
JT  - Breastfeeding medicine : the official journal of the Academy of Breastfeeding 
      Medicine
JID - 101260777
SB  - IM
MH  - Absorptiometry, Photon
MH  - Aftercare
MH  - *Body Composition
MH  - *Breast Feeding
MH  - *Child Development
MH  - Diet
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intensive Care Units, Neonatal
MH  - Male
MH  - *Milk, Human
MH  - Neurodevelopmental Disorders
MH  - Patient Discharge
MH  - Pilot Projects
PMC - PMC7360515
OTO - NOTNLM
OT  - body composition
OT  - growth
OT  - human milk
OT  - neurodevelopment
OT  - nutrition
OT  - premature infants
COIS- A.B.H. receives research support from Fresenius Kabi for the Randomized SMOF 
      Study and Prolacta Bioscience for an unrelated study in cardiac infants and the 
      human milk cream study. K.M.H. receives speaker honoraria from Prolacta 
      Bioscience and Abbott Nutrition. No industry funding was received for this study. 
      The remaining authors declare no potential conflict of interest.
EDAT- 2020/04/17 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/05/08
CRDT- 2020/04/17 06:00
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/04/17 06:00 [entrez]
PHST- 2020/05/08 00:00 [pmc-release]
AID - 10.1089/bfm.2019.0210 [pii]
AID - 10.1089/bfm.2019.0210 [doi]
PST - ppublish
SO  - Breastfeed Med. 2020 May;15(5):304-311. doi: 10.1089/bfm.2019.0210. Epub 2020 Apr 
      16.