PMID- 32298719
OWN - NLM
STAT- MEDLINE
DCOM- 20210311
LR  - 20210311
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 156
DP  - 2020 Aug 1
TI  - A bio-inspired magnetic natural hydrogel containing gelatin and alginate as a 
      drug delivery system for cancer chemotherapy.
PG  - 438-445
LID - S0141-8130(20)32930-5 [pii]
LID - 10.1016/j.ijbiomac.2020.04.074 [doi]
AB  - This study aimed to design and development of a magnetic natural hydrogel based 
      on alginate (Alg), gelatin (Gel), and Fe(3)O(4) magnetic nanoparticles (MNPs) as 
      an efficient and "smart" drug delivery system (DDS) for cancer therapy. First, 
      Alg was partially oxidized (OAlg), and then the Alg-Gel chemical hydrogel was 
      synthesized through "Shift-Base" condensation reaction. Afterward, Fe(3)O(4) NPs 
      were incorporated into the hydrogel through in situ chemical co-precipitation 
      approach. The scanning electron microscopy (SEM) image exhibited that the 
      fabricated Alg-Gel hydrogel has porous microstructure without microphase 
      separation. Transmission electron microscopy (TEM) revealed the well-defined 
      formation of Fe(3)O(4) NPs throughout the Alg-Gel hydrogel with spherical shapes 
      in the size range of 25 +/- 10 nm. Saturation magnetization (delta(s)) value of the 
      Alg-Gel/Fe(3)O(4) was obtained to be 31 emu g(-1) that represent proper magnetic 
      property for "smart" drug delivery purposes. The obtained Alg-Gel/Fe(3)O(4) was 
      loaded with doxorubicin hydrochloride (Dox), and its drug loading and 
      encapsulation efficiencies as well as its anticancer activity was investigated 
      against Hela cells. The formulated Alg-Gel/Fe(3)O(4)-Dox exhibited pH-dependent 
      drug release behavior due to presence of carboxylic acid groups in the DDS. 
      According to the results, the Alg-Gel/Fe(3)O(4) magnetic hydrogel can be 
      considered as an efficient and "smart" DDS for cancer therapy and diagnosis.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Jahanban-Esfahlan, Rana
AU  - Jahanban-Esfahlan R
AD  - Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Derakhshankhah, Hossein
AU  - Derakhshankhah H
AD  - Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University 
      of Medical Sciences, Kermanshah, Iran.
FAU - Haghshenas, Babak
AU  - Haghshenas B
AD  - Regenerative Medicine Research Center, Health Technology Institute, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Massoumi, Bakhshali
AU  - Massoumi B
AD  - Department of Chemistry, Payame Noor University, Tehran, Iran.
FAU - Abbasian, Mojtaba
AU  - Abbasian M
AD  - Department of Chemistry, Payame Noor University, Tehran, Iran.
FAU - Jaymand, Mehdi
AU  - Jaymand M
AD  - Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran. Electronic address: 
      mehdi.jaymand@kums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20200413
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Alginates)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biological Products)
RN  - 0 (Drug Carriers)
RN  - 0 (Hydrogels)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Alginates/*chemistry
MH  - Antineoplastic Agents/*administration & dosage/pharmacology
MH  - Biological Products/*chemistry
MH  - Chemistry Techniques, Synthetic
MH  - Drug Carriers/*chemistry
MH  - Drug Compounding
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Gelatin/*chemistry
MH  - Humans
MH  - Hydrogels/*chemistry
MH  - Magnetic Iron Oxide Nanoparticles/chemistry/ultrastructure
MH  - Molecular Structure
OTO - NOTNLM
OT  - Alginate
OT  - Cancer therapy
OT  - Chemical hydrogel
OT  - Drug delivery
OT  - Gelatin
OT  - Magnetic nanoparticles
COIS- Declaration of competing interest The authors declare no competing financial 
      interest.
EDAT- 2020/04/17 06:00
MHDA- 2021/03/12 06:00
CRDT- 2020/04/17 06:00
PHST- 2020/02/29 00:00 [received]
PHST- 2020/04/09 00:00 [revised]
PHST- 2020/04/11 00:00 [accepted]
PHST- 2020/04/17 06:00 [pubmed]
PHST- 2021/03/12 06:00 [medline]
PHST- 2020/04/17 06:00 [entrez]
AID - S0141-8130(20)32930-5 [pii]
AID - 10.1016/j.ijbiomac.2020.04.074 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Aug 1;156:438-445. doi: 10.1016/j.ijbiomac.2020.04.074. 
      Epub 2020 Apr 13.