PMID- 32300160
OWN - NLM
STAT- MEDLINE
DCOM- 20201125
LR  - 20210416
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Apr 16
TI  - Peripapillary microvascular changes in patients with systemic hypertension: An 
      optical coherence tomography angiography study.
PG  - 6541
LID - 10.1038/s41598-020-63603-6 [doi]
LID - 6541
AB  - The purpose of this study was to investigate changes in peripapillary 
      microvasculature using optical coherence tomography angiography (OCTA) in 
      systemic hypertension (HTN) patients. This was a cross-sectional study. Based on 
      the duration of HTN, seventy-eight HTN patients were divided into two groups. 
      (HTN group 1: <10 years, 38 eyes; HTN group 2: >/=10 years, 40 eyes) and 90 control 
      subjects. All subjects underwent 6 x 6 mm OCTA scan centered on the optic nerve 
      head. We analyzed peripapillary vessel density (VD) and perfusion density (PD) in 
      superficial capillary plexus among three groups. The average ganglion cell-inner 
      plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) thicknesses of HTN 
      group 2 were thinner than those of the control group (p = 0.016, and 0.035, 
      respectively). HTN group 2 showed lower peripapillary VD and PD than the control 
      group. However, there were no differences between HTN group 1 and the control 
      group in OCT and peripapillary OCTA parameters. In HTN patients, the 
      peripapillary VD, PD and GC-IPL, RNFL thicknesses correlated significantly. OCTA 
      showed that the peripapillary VD and PD were lower in HTN patients with a 
      duration >/=10 years compared with those of normal controls. Peripapillary 
      microvasculature was correlated with the RNFL and GC-IPL thicknesses. HTN 
      duration should therefore be considered when evaluating peripapillary 
      microvasculature using OCTA.
FAU - Shin, Yong-Il
AU  - Shin YI
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Nam, Ki-Yup
AU  - Nam KY
AD  - Department of Ophthalmology, Gyeongsang National University Changwon Hospital, 
      Changwon, Republic of Korea.
FAU - Lee, Woo-Hyuk
AU  - Lee WH
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Ryu, Cheon-Kuk
AU  - Ryu CK
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Lim, Hyung-Bin
AU  - Lim HB
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Jo, Young-Joon
AU  - Jo YJ
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Kim, Jung-Yeul
AU  - Kim JY
AUID- ORCID: 0000-0003-3679-1310
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea. kimjy@cnu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20200416
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Hypertension/*diagnostic imaging/*pathology
MH  - Macula Lutea
MH  - Male
MH  - Microvessels/*diagnostic imaging/*pathology
MH  - Middle Aged
MH  - Optic Disk/*blood supply/*diagnostic imaging/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - *Tomography, Optical Coherence
PMC - PMC7162882
COIS- The authors declare no competing interests.
EDAT- 2020/04/18 06:00
MHDA- 2020/11/26 06:00
PMCR- 2020/04/16
CRDT- 2020/04/18 06:00
PHST- 2019/10/28 00:00 [received]
PHST- 2020/04/01 00:00 [accepted]
PHST- 2020/04/18 06:00 [entrez]
PHST- 2020/04/18 06:00 [pubmed]
PHST- 2020/11/26 06:00 [medline]
PHST- 2020/04/16 00:00 [pmc-release]
AID - 10.1038/s41598-020-63603-6 [pii]
AID - 63603 [pii]
AID - 10.1038/s41598-020-63603-6 [doi]
PST - epublish
SO  - Sci Rep. 2020 Apr 16;10(1):6541. doi: 10.1038/s41598-020-63603-6.