PMID- 32301691
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2149-3235 (Print)
IS  - 2149-3057 (Electronic)
IS  - 2149-3235 (Linking)
VI  - 46
IP  - 3
DP  - 2020 May
TI  - Investigation of the interchromosomal effects in male carriers with structural 
      chromosomal abnormalities using FISH.
PG  - 178-185
LID - 10.5152/tud.2020.19255 [doi]
AB  - OBJECTIVE: The interchromosomal effect (ICE) refers to the uncertainty during 
      meiosis where the rearrangement of the chromosomes affects the segregation of the 
      chromosomes that are not involved in the structural chromosomal abnormalities. 
      The aim of this study is to investigate the existence of ICE in the sperm nuclei 
      of the males who have structural chromosomal abnormalities. MATERIAL AND METHODS: 
      Nine male individuals who are the carriers of the structural chromosomal 
      abnormalities (patient group) and 14 male individuals who did not have any 
      chromosomal abnormalities (control group) were diagnosed by the classical 
      cytogenetic analysis. The aneuploidy of chromosomes 2, 3, 12, 13, 17, 18, 21, X, 
      and Y in the sperm nuclei was investigated using the fluorescence in situ 
      hybridization (FISH) method in these individuals. The patient group included 5 
      Robertsonian translocation (ROB) carriers, 3 reciprocal translocation (RCP) 
      carriers, and 1 inversion carrier. RESULTS: A total of 51921 sperm nuclei were 
      analyzed (19484 from the patient group and 32437 from the control group). While 
      ICE was determined in 4 of 5 patients who were the carriers of ROB and an 
      inversion carrier patient, it was not determined in the patient carrier of RCP. 
      CONCLUSION: Our results suggest that there is ICE in the male carriers with a 
      structural chromosomal abnormality, which appears to be translocation, 
      breakpoint, chromosome, and patient dependent.
FAU - Balasar, Ozgur
AU  - Balasar O
AUID- ORCID: 0000-0002-2945-9355
AD  - Department of Medical Genetics, Konya Training and Research Hospital, Konya, 
      Turkey.
FAU - Acar, Hasan
AU  - Acar H
AUID- ORCID: 0000-0002-7139-9261
AD  - Department of Medical Genetics, Necmettin Erbakan University Meram School of 
      Medicine, Konya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200314
PL  - Turkey
TA  - Turk J Urol
JT  - Turkish journal of urology
JID - 101643563
PMC - PMC7219968
COIS- Conflict of Interest: The authors have no conflicts of interest to declare.
EDAT- 2020/04/18 06:00
MHDA- 2020/04/18 06:01
PMCR- 2020/05/01
CRDT- 2020/04/18 06:00
PHST- 2019/12/09 00:00 [received]
PHST- 2020/03/06 00:00 [accepted]
PHST- 2020/04/18 06:00 [pubmed]
PHST- 2020/04/18 06:01 [medline]
PHST- 2020/04/18 06:00 [entrez]
PHST- 2020/05/01 00:00 [pmc-release]
AID - tud.2020.19255 [pii]
AID - tju-46-3-178 [pii]
AID - 10.5152/tud.2020.19255 [doi]
PST - epublish
SO  - Turk J Urol. 2020 Mar 14;46(3):178-185. doi: 10.5152/tud.2020.19255. Print 2020 
      May.