PMID- 32301971
OWN - NLM
STAT- MEDLINE
DCOM- 20200821
LR  - 20200821
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 61
IP  - 4
DP  - 2020 Apr 9
TI  - Interdigitation Zone Change According to Glaucoma-Stage Advancement.
PG  - 20
LID - 10.1167/iovs.61.4.20 [doi]
LID - 20
AB  - PURPOSE: To compare the macular interdigitation zone (IZ) of normal eyes with 
      eyes showing different normal-tension glaucoma (NTG) stages. METHODS: Forty-two 
      normal eyes (age, 56 +/- 5.4 years), 45 pre-perimetric eyes (age, 59 +/- 6.9 years), 
      51 mild-to-moderate glaucoma eyes (age, 58 +/- 7.2 years; mean deviation [MD], -5.5 
      +/- 3.0 dB), and 50 severe glaucoma eyes (age, 59 +/- 6.9 years; MD, -15.1 +/- 5.4 dB) 
      were enrolled. All of the subjects underwent high-resolution spectral-domain 
      optical coherence tomography (SD-OCT) to obtain 19 horizontal and 19 vertical 
      macular B-scans 9 mm in length. The en face image of the scan area was divided 
      into 589 rectangular boxes (side length of 375 microm). The IZ locations were marked 
      on the corresponding image boxes. The IZ area was then quantified according to 
      the number of boxes showing IZs among the 589 total boxes. RESULTS: The IZ area 
      in the severe glaucoma eyes was significantly smaller than in the 
      mild-to-moderate glaucoma eyes (28.99 +/- 7.88 mm2 vs. 40.79 +/- 7.46 mm2; P < 
      0.001), was smaller in the mild-to-moderate glaucoma eyes than in the 
      pre-perimetric glaucoma eyes (40.79 +/- 7.46 mm2 vs. 49.92 +/- 8.10 mm2; P < 0.001), 
      and was smaller still in the pre-perimetric glaucoma eyes than in the normal eyes 
      (49.92 +/- 8.10 mm2 vs. 56.85 +/- 7.94 mm2; P < 0.001). In the 146 NTG eyes, a 
      statistically significant correlation was found between IZ area and MD (r = 0.64; 
      P < 0.001). CONCLUSIONS: SD-OCT revealed a reduction in IZ area in NTG eyes, and 
      the extent of the reduction was positively associated with glaucoma severity. 
      These findings suggest, though tentatively, that changes in the outer retinal 
      layer can occur in the course of glaucoma progression.
FAU - Ha, Ahnul
AU  - Ha A
AD  - ,.
AD  - ,.
FAU - Kim, Young Kook
AU  - Kim YK
AD  - ,.
AD  - ,.
FAU - Lee, Jinho
AU  - Lee J
AD  - ,.
AD  - ,.
FAU - Bak, Eunoo
AU  - Bak E
AD  - ,.
AD  - ,.
FAU - Han, Young Soo
AU  - Han YS
AD  - ,.
AD  - ,.
FAU - Kim, Yong Woo
AU  - Kim YW
AD  - ,.
AD  - ,.
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
AD  - ,.
AD  - ,.
FAU - Park, Ki Ho
AU  - Park KH
AD  - ,.
AD  - ,.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Low Tension Glaucoma/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence
MH  - Visual Field Tests
MH  - Visual Fields/physiology
PMC - PMC7401448
COIS- Disclosure: A. Ha, None; Y.K. Kim, None; J. Lee, None; E. Bak, None; Y.S. Han, 
      None; Y.W. Kim, None; J.W. Jeoung, None; K.H. Park, None
EDAT- 2020/04/18 06:00
MHDA- 2020/08/22 06:00
PMCR- 2020/04/17
CRDT- 2020/04/18 06:00
PHST- 2020/04/18 06:00 [entrez]
PHST- 2020/04/18 06:00 [pubmed]
PHST- 2020/08/22 06:00 [medline]
PHST- 2020/04/17 00:00 [pmc-release]
AID - 2764829 [pii]
AID - IOVS-19-28616 [pii]
AID - 10.1167/iovs.61.4.20 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):20. doi: 10.1167/iovs.61.4.20.