PMID- 32302097
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210702
IS  - 1520-5010 (Electronic)
IS  - 0893-228X (Print)
IS  - 0893-228X (Linking)
VI  - 33
IP  - 5
DP  - 2020 May 18
TI  - Particulate Matter Toxicity Is Nrf2 and Mitochondria Dependent: The Roles of 
      Metals and Polycyclic Aromatic Hydrocarbons.
PG  - 1110-1120
LID - 10.1021/acs.chemrestox.0c00007 [doi]
AB  - Particulate matter (PM), an important component of air pollution, induces 
      significant adverse health effects. Many of the observed health effects caused by 
      inhaled PM are associated with oxidative stress and inflammation. This 
      association has been linked in particular to the particles' chemical components, 
      especially the inorganic/metal and the organic/polycyclic aromatic hydrocarbon 
      (PAH) fractions, and their ability to generate reactive oxygen species in 
      biological systems. The transcription factor NF-E2 nuclear factor 
      erythroid-related factor 2 (Nrf2) is activated by redox imbalance and regulates 
      the expression of phase II detoxifying enzymes. Nrf2 plays a key role in 
      preventing PM-induced toxicity by protecting against oxidative damage and 
      inflammation. This review focuses on specific PM fractions, particularly the 
      dissolved metals and PAH fractions, and their roles in inducing oxidative stress 
      and inflammation in cell and animal models with respect to Nrf2 and mitochondria.
FAU - Pardo, Michal
AU  - Pardo M
AUID- ORCID: 0000-0001-6480-1171
AD  - Department of Earth and Planetary Sciences, Weizmann Institute of Science, 
      Rehovot 76100, Israel.
FAU - Qiu, Xinghua
AU  - Qiu X
AUID- ORCID: 0000-0001-9874-8030
AD  - State Key Joint Laboratory for Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering, and Center for Environment and 
      Health, Peking University, Beijing 100871, P.R. China.
FAU - Zimmermann, Ralf
AU  - Zimmermann R
AD  - Joint Mass Spectrometry Centre, University of Rostock, 18055 Rostock, Germany.
AD  - Joint Mass Spectrometry Centre, Comprehensive Molecular Analytics (CMA) 
      Cooperation Group Helmholtz Zentrum, 81379 Munchen, Germany.
FAU - Rudich, Yinon
AU  - Rudich Y
AUID- ORCID: 0000-0003-3149-0201
AD  - Department of Earth and Planetary Sciences, Weizmann Institute of Science, 
      Rehovot 76100, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200430
PL  - United States
TA  - Chem Res Toxicol
JT  - Chemical research in toxicology
JID - 8807448
RN  - 0 (Metals, Heavy)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Particulate Matter)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Inflammation/metabolism
MH  - Metals, Heavy/metabolism/*toxicity
MH  - Mitochondria/*drug effects/*metabolism
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Particulate Matter/metabolism/*toxicity
MH  - Polycyclic Aromatic Hydrocarbons/metabolism/*toxicity
PMC - PMC7304922
COIS- The authors declare no competing financial interest.
EDAT- 2020/04/18 06:00
MHDA- 2021/07/03 06:00
PMCR- 2020/06/19
CRDT- 2020/04/18 06:00
PHST- 2020/04/18 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2020/04/18 06:00 [entrez]
PHST- 2020/06/19 00:00 [pmc-release]
AID - 10.1021/acs.chemrestox.0c00007 [doi]
PST - ppublish
SO  - Chem Res Toxicol. 2020 May 18;33(5):1110-1120. doi: 
      10.1021/acs.chemrestox.0c00007. Epub 2020 Apr 30.