PMID- 32302803
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 414
DP  - 2020 Jul 15
TI  - Prognostic value of macular ganglion cell layer thickness for visual outcome in 
      parasellar tumors.
PG  - 116823
LID - S0022-510X(20)30159-3 [pii]
LID - 10.1016/j.jns.2020.116823 [doi]
AB  - PURPOSE: Optic nerve compression by mass lesions at the optic chiasm leads to 
      loss of visual function which can be recovered after decompression surgery. In 
      this study, we evaluated the prognostic ability of macular ganglion cell layer 
      (mGCL) thickness measured with spectral-domain optical coherence tomography 
      (SD-OCT) for predicting postoperative visual outcome of compressive optic 
      neuropathy (CON) related to parasellar tumors. METHODS: This observational cohort 
      study used data from the Department of Neurosurgery and Ophthalmology, Seoul 
      National University Bundang Hospital between 2013 and 2018. Seventy-nine eyes 
      from 79 patients with CON due to parasellar tumors who underwent surgery were 
      included. Patients were divided into either a visual recovery group or a 
      non-recovery group according to the degree of postoperative visual field (VF) 
      impairment. SD-OCT scanning with automated segmentation was performed to measure 
      the circumpapillary retinal nerve fiber layer (cpRNFL) and the mGCL thickness in 
      the nine macular subfields as defined by the ETDRS and 8 x 8 posterior pole grid. 
      Correlations between preoperative cpRNFL thickness, mGCL thickness and 
      postoperative VF sensitivity were assessed. The prognostic ability of mGCL 
      thickness for predicting visual recovery after surgical decompression in each 
      ETDRS subfield and posterior pole grid quadrant was evaluated. RESULTS: The 
      central inferonasal and superonasal quadrant mGCL thicknesses measured by the 
      8 x 8 posterior pole grid showed the best predictability of postoperative visual 
      outcome (AUROC = 0.963 and 0.953, respectively), which was superior to the 
      prognostic power of the average cpRNFL. The central inferonasal quadrant mGCL 
      thickness significantly correlated with the superotemporal quadrant VF 
      sensitivity (R(2) = 0.589). CONCLUSIONS: The mGCL thickness in the central nasal 
      quadrants measured by SD-OCT is an excellent predictor of visual recovery after 
      chiasmal decompression.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Yoo, Yung Ju
AU  - Yoo YJ
AD  - Department of Ophthalmology, Kangwon National University Hospital, Kangwon 
      National University Graduate School of Medicine, Chuncheon, Republic of Korea.
FAU - Hwang, Jeong-Min
AU  - Hwang JM
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Republic of Korea.
FAU - Yang, Hee Kyung
AU  - Yang HK
AD  - Department of Ophthalmology, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Republic of Korea. Electronic 
      address: nan282@snu.ac.kr.
FAU - Joo, Jin-Deok
AU  - Joo JD
AD  - Department of Neurosurgery, Jeju National University Hospital, Jeju National 
      University College of Medicine, Jeju, Republic of Korea.
FAU - Kim, Young-Hoon
AU  - Kim YH
AD  - Department of Neurosurgery, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Kim, Chae-Yong
AU  - Kim CY
AD  - Department of Neurosurgery, Seoul National University College of Medicine, Seoul 
      National University Bundang Hospital, Seongnam, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200406
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - *Brain Neoplasms/complications/diagnosis
MH  - Humans
MH  - Nerve Fibers
MH  - *Optic Nerve Diseases/etiology
MH  - Prognosis
MH  - *Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Hemianopia
OT  - Imaging
OT  - Pituitary neoplasms
OT  - Retinal ganglion cells
OT  - Visual field
COIS- Declaration of Competing Interest None.
EDAT- 2020/04/18 06:00
MHDA- 2021/05/11 06:00
CRDT- 2020/04/18 06:00
PHST- 2019/12/23 00:00 [received]
PHST- 2020/03/18 00:00 [revised]
PHST- 2020/04/03 00:00 [accepted]
PHST- 2020/04/18 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2020/04/18 06:00 [entrez]
AID - S0022-510X(20)30159-3 [pii]
AID - 10.1016/j.jns.2020.116823 [doi]
PST - ppublish
SO  - J Neurol Sci. 2020 Jul 15;414:116823. doi: 10.1016/j.jns.2020.116823. Epub 2020 
      Apr 6.