PMID- 32303623
OWN - NLM
STAT- MEDLINE
DCOM- 20200819
LR  - 20200819
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Print)
IS  - 0040-6376 (Linking)
VI  - 75
IP  - 7
DP  - 2020 Jul
TI  - Utility of routine screening for alpha-1 antitrypsin deficiency in patients with 
      bronchiectasis.
PG  - 592-593
LID - 10.1136/thoraxjnl-2019-214195 [doi]
AB  - Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines 
      for bronchiectasis from the British Thoracic Society do not recommend to 
      routinely test patients for AATD. In contrast, guidelines for AATD recommend 
      routine screening. This contradiction, in part, results from the lack of data 
      from large studies performing comprehensive screening. We screened 1600 patients 
      with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only 
      eight individuals with AATD were identified representing 0.5% of the overall 
      population. We conclude that routine screening for AATD in bronchiectasis in the 
      UK has a low rate of detection. Further studies are required in different 
      geographical regions, which may have a higher prevalence of AATD.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Carreto, Luis
AU  - Carreto L
AD  - Respiratory Medicine, Hospital Professor Fernando Fonseca (HFF), Lisbon, 
      Portugal.
FAU - Morrison, Meghan
AU  - Morrison M
AD  - School of Medicine, University of Dundee, Dundee, UK.
FAU - Donovan, Jackie
AU  - Donovan J
AD  - Biochemistry, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
FAU - Finch, Simon
AU  - Finch S
AD  - Division of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.
FAU - Tan, Gan Liang
AU  - Tan GL
AD  - Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
FAU - Fardon, Tom
AU  - Fardon T
AD  - Respiratory Medicine, University of Dundee, Dundee, UK.
AD  - Respiratory Medicine, NHS Tayside, Dundee, UK.
FAU - Wilson, Robert
AU  - Wilson R
AD  - Host Defence Unit, Division of Respiratory Medicine, Royal Brompton Hospital, 
      London, UK.
FAU - Furrie, Elisabeth
AU  - Furrie E
AD  - Department of Immunology, Department of Medicine, Ninewells Hospital, Dundee, UK.
FAU - Loebinger, Michael
AU  - Loebinger M
AD  - Host Defence Unit, Division of Respiratory Medicine, Royal Brompton Hospital, 
      London, UK.
FAU - Chalmers, James D
AU  - Chalmers JD
AD  - Division of Molecular and Clinical Medicine, University of Dundee, Dundee, UK 
      jchalmers@dundee.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200417
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
MH  - Bronchiectasis/diagnosis/*etiology
MH  - Humans
MH  - Mass Screening/*statistics & numerical data
MH  - *Practice Guidelines as Topic
MH  - alpha 1-Antitrypsin Deficiency/complications/*diagnosis
PMC - PMC7361016
OTO - NOTNLM
OT  - alpha1 antitrypsin deficiency
OT  - bronchiectasis
OT  - clinical epidemiology
COIS- Competing interests: ML declares personal fees from Grifols, Bayer, Polyphor and 
      Astrazeneca. JDC declares research grants or personal fees from Glaxosmithkline, 
      Boehringer-Ingelheim, Astrazeneca, Pfizer, Bayer, Grifols, Aradigm, Napp and 
      Insmed outside the submitted work.
EDAT- 2020/04/19 06:00
MHDA- 2020/08/20 06:00
PMCR- 2020/07/15
CRDT- 2020/04/19 06:00
PHST- 2019/10/12 00:00 [received]
PHST- 2020/02/15 00:00 [revised]
PHST- 2020/03/18 00:00 [accepted]
PHST- 2020/04/19 06:00 [pubmed]
PHST- 2020/08/20 06:00 [medline]
PHST- 2020/04/19 06:00 [entrez]
PHST- 2020/07/15 00:00 [pmc-release]
AID - thoraxjnl-2019-214195 [pii]
AID - 10.1136/thoraxjnl-2019-214195 [doi]
PST - ppublish
SO  - Thorax. 2020 Jul;75(7):592-593. doi: 10.1136/thoraxjnl-2019-214195. Epub 2020 Apr 
      17.