PMID- 32303979
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210130
IS  - 2193-8237 (Print)
IS  - 2193-651X (Electronic)
VI  - 9
IP  - 1
DP  - 2020 Jun
TI  - Sufentanil Sublingual for Acute Post-Operative Pain: A Systematic Literature 
      Review Focused on Pain Intensity, Adverse Events, and Patient Satisfaction.
PG  - 217-230
LID - 10.1007/s40122-020-00166-4 [doi]
AB  - CONTEXT: Pain is commonly experienced among patients after surgical procedures. 
      Clinical pain management after surgery is far from being successful. Patients may 
      control postoperative pain by self-administration of intravenous opioids using 
      devices designed for this purpose (patient-controlled analgesia or PCA). PCA 
      devices have been developed including the sufentanil sublingual tablet system 
      (SSTS). A systematic review of the use of SSTS for postoperative pain is needed 
      to identify an alternative method of pain management. OBJECTIVES: To 
      systematically review literature to establish the efficacy and the safety of PCA 
      with SSTS used in the treatment of moderate-to-severe acute post-operative pain 
      in a hospital setting. METHODS: Embase, MEDLINE, Google Scholar, and Cochrane 
      Central Trials Register were systematically searched in December 2019 for studies 
      examining SSTS for pain in adult after surgical procedures. The methodological 
      quality of the studies and their results were appraised using the Consensus-based 
      Standards for the Selection of Health Measurement Instruments (COSMIN) checklist 
      and specific measurement properties criteria, respectively. RESULTS: Sixteen 
      studies evaluating SSTS were included for a total of 2311 patients. All 
      participants in the SSTS group reported NRS </= 4 within 24 h after surgery. 
      Patient satisfaction was high, with a minimum of 70% satisfaction among patients 
      treated with SSTS. The most common adverse events (AEs) overall for SSTS 15 and 
      30 mcg were nausea, vomiting, and headache. AEs observed in the studies were 
      generally consistent with those associated with opioids and the postsurgical 
      setting. CONCLUSIONS: SSTS is an important system for the management of 
      moderate-to-severe acute pain in a hospital setting. SSTS is well tolerated, with 
      no unexpected adverse events (AEs) and no clinically meaningful vital sign 
      changes. These data confirm the safety and tolerability of the SSTS. Successful 
      pain management resulted in a high level of acceptance of the SSTS by patients 
      with high satisfaction for the method of pain control.
FAU - Giaccari, Luca G
AU  - Giaccari LG
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Coppolino, Francesco
AU  - Coppolino F
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Aurilio, Caterina
AU  - Aurilio C
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Esposito, Valentina
AU  - Esposito V
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Pace, Maria Caterina
AU  - Pace MC
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Paladini, Antonella
AU  - Paladini A
AD  - Department of MESVA, University of L'Aquila, Aquila, Italy.
FAU - Passavanti, Maria Beatrice
AU  - Passavanti MB
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Pota, Vincenzo
AU  - Pota V
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Sansone, Pasquale
AU  - Sansone P
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy. pasquale.sansone@unicampania.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200417
PL  - New Zealand
TA  - Pain Ther
JT  - Pain and therapy
JID - 101634491
PMC - PMC7203368
OTO - NOTNLM
OT  - Adverse events (AEs)
OT  - Pain intensity
OT  - Patient satisfaction
OT  - Patient-controlled analgesia (PCA)
OT  - Post-operative pain
OT  - Sufentanil sublingual tablet system (SSTS)
EDAT- 2020/04/19 06:00
MHDA- 2020/04/19 06:01
PMCR- 2020/04/17
CRDT- 2020/04/19 06:00
PHST- 2020/03/10 00:00 [received]
PHST- 2020/04/19 06:00 [pubmed]
PHST- 2020/04/19 06:01 [medline]
PHST- 2020/04/19 06:00 [entrez]
PHST- 2020/04/17 00:00 [pmc-release]
AID - 10.1007/s40122-020-00166-4 [pii]
AID - 166 [pii]
AID - 10.1007/s40122-020-00166-4 [doi]
PST - ppublish
SO  - Pain Ther. 2020 Jun;9(1):217-230. doi: 10.1007/s40122-020-00166-4. Epub 2020 Apr 
      17.