PMID- 32304796
OWN - NLM
STAT- MEDLINE
DCOM- 20200731
LR  - 20200731
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 163
DP  - 2020 May
TI  - Associations of iron markers with type 2 diabetes mellitus and metabolic 
      syndrome: Results from the prospective SHIP study.
PG  - 108149
LID - S0168-8227(20)30399-5 [pii]
LID - 10.1016/j.diabres.2020.108149 [doi]
AB  - AIMS: To assess the role of serum ferritin and transferrin with prevalent and 
      incident type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) and 
      whether these associations are independent of inflammatory markers and hepatic 
      enzymes. METHODS: We analyzed data from 3,232 participants aged 20-81 years of 
      the population-based Study of Health in Pomerania (SHIP) from Northeast Germany 
      with a median follow-up time of 10.6 years. Logistic and Cox regression analyses 
      were performed. RESULTS: Serum ferritin concentrations were associated with a 
      higher prevalence of T2DM (total population OR: 1.16 [95% CI: 1.07, 1.26]; men 
      OR: 1.18 [95% CI: 1.08, 1.30) and MetS (total population OR: 1.27 [95% CI: 1.16, 
      1.38]; men OR: 1.26 [95% CI: 1.15, 1.38]) in the total population and men 
      independently of inflammatory markers and hepatic enzymes. In longitudinal 
      analyses, baseline ferritin concentrations were associated with a higher risk of 
      incident T2DM in women (HR: 1.38 [95% CI: 1.10, 1.71]), but not in men or in the 
      total population and also with a higher risk of incident MetS (HR: 1.09 [95% CI: 
      1.01, 1.17]) in the total population. These longitudinal associations attenuated 
      considerably after adjustment for hepatic enzymes but not inflammatory markers. 
      Transferrin was not associated with any of the outcomes. CONCLUSIONS: Our results 
      suggest a link between ferritin and T2DM and MetS, which might be partially 
      explained by hepatic dysfunction.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Pitchika, Anitha
AU  - Pitchika A
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany. Electronic address: anitha.pitchika@uni-greifswald.de.
FAU - Schipf, Sabine
AU  - Schipf S
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany.
FAU - Nauck, Matthias
AU  - Nauck M
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Greifswald, Germany; German Center for Cardiovascular Research (DZHK 
      e.V.), Partner site Greifswald, Greifswald, Germany.
FAU - Dorr, Marcus
AU  - Dorr M
AD  - German Center for Cardiovascular Research (DZHK e.V.), Partner site Greifswald, 
      Greifswald, Germany; Department of Internal Medicine B, University Medicine 
      Greifswald, Greifswald, Germany.
FAU - Lerch, Markus M
AU  - Lerch MM
AD  - Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
FAU - Felix, Stephan B
AU  - Felix SB
AD  - German Center for Cardiovascular Research (DZHK e.V.), Partner site Greifswald, 
      Greifswald, Germany; Department of Internal Medicine B, University Medicine 
      Greifswald, Greifswald, Germany.
FAU - Markus, Marcello Ricardo Paulista
AU  - Markus MRP
AD  - German Center for Cardiovascular Research (DZHK e.V.), Partner site Greifswald, 
      Greifswald, Germany; Department of Internal Medicine B, University Medicine 
      Greifswald, Greifswald, Germany; DZD (German Center for Diabetes Research), Site 
      Greifswald, Greifswald, Germany.
FAU - Volzke, Henry
AU  - Volzke H
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Cardiovascular Research (DZHK e.V.), Partner site 
      Greifswald, Greifswald, Germany; DZD (German Center for Diabetes Research), Site 
      Greifswald, Greifswald, Germany.
FAU - Ittermann, Till
AU  - Ittermann T
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20200415
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Biomarkers)
RN  - 0 (Transferrin)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Biomarkers/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Ferritins/*blood
MH  - Humans
MH  - Iron/*metabolism
MH  - Male
MH  - Metabolic Syndrome/*diagnosis/epidemiology
MH  - Middle Aged
MH  - Prospective Studies
MH  - Transferrin/*metabolism
OTO - NOTNLM
OT  - Ferritin
OT  - Iron markers
OT  - Liver dysfunction
OT  - Metabolic syndrome
OT  - Transferrin
OT  - Type 2 diabetes
EDAT- 2020/04/19 06:00
MHDA- 2020/08/01 06:00
CRDT- 2020/04/19 06:00
PHST- 2019/10/08 00:00 [received]
PHST- 2020/03/04 00:00 [revised]
PHST- 2020/04/07 00:00 [accepted]
PHST- 2020/04/19 06:00 [pubmed]
PHST- 2020/08/01 06:00 [medline]
PHST- 2020/04/19 06:00 [entrez]
AID - S0168-8227(20)30399-5 [pii]
AID - 10.1016/j.diabres.2020.108149 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2020 May;163:108149. doi: 10.1016/j.diabres.2020.108149. 
      Epub 2020 Apr 15.