PMID- 32305278
OWN - NLM
STAT- MEDLINE
DCOM- 20200929
LR  - 20200929
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 29
IP  - 6
DP  - 2020 Jun
TI  - Serum Neurofilament Light Chain as a Predictive Biomarker for Ischemic Stroke 
      Outcome: A Systematic Review and Meta-analysis.
PG  - 104813
LID - S1052-3057(20)30197-X [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2020.104813 [doi]
AB  - BACKGROUND: Stroke is the leading cause of death and long-term disability 
      worldwide. The purpose of the study is to examine the role of serum neurofilament 
      light chain (sNfL) as a predictive biomarker for ischemic stroke outcome. 
      METHODS: We searched PubMed, Web of Science, and EMBASE for potential studies 
      published in English previous to November 15, 2019. Two independent reviewers 
      screened the search results for studies reporting the correlation between sNfL 
      and stroke outcome in ischemic stroke or transient ischemic attack patients. The 
      Newcastle-Ottawa Scale was adopted to evaluate the quality of the included 
      studies. The pooled odds ratio (OR) of sNfL for stroke functional outcome was 
      calculated with the Comprehensive Meta-Analysis software, version 2. 
      Heterogeneity and publication bias were assessed with the I(2) test and funnel 
      plot, respectively. RESULTS: Seven studies met the inclusion criteria. The 
      qualities of the included studies ranged from moderate to high. Despite of the 
      different methods used to measure infarct volume, 5 of the included studies 
      reported similar results about the association between sNfL and infarct volume. 
      Two studies investigating the relationship between sNfL and recurrent ischemic 
      events both reported positive results. In pooled analysis with the adjusted odds 
      ratios (Ors) from multivariate regression models, the meta-analysis reached a 
      pooled adjusted OR = 1.71 [95% CI: 1.17-4.29], which represented that the 
      patients with higher sNfL, compared with lower sNfL patients, had a 1.71 times 
      higher risk of poor functional outcome during follow-up. Both meta-regression and 
      subgroup analysis found that sampling time was an important source of 
      heterogeneity. Based on funnel plot and Egger's test, we did not detect obvious 
      publication bias in our study. CONCLUSIONS: The sNfL was a promising predictive 
      biomarker for ischemic stroke outcome, and blood sampling time was of great 
      importance in the correlation. The temporal change of sNfL after stroke deserves 
      further exploration in large longitudinal studies and a standardized procedure is 
      warranted.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Liu, Daoshen
AU  - Liu D
AD  - Department of Neurology, Xijing Hospital, the Fourth Military Medical University, 
      Xi'an, Shaanxi, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Neurology, Xijing Hospital, the Fourth Military Medical University, 
      Xi'an, Shaanxi, China.
FAU - Wang, Xuanying
AU  - Wang X
AD  - Department of Neurology, Xijing Hospital, the Fourth Military Medical University, 
      Xi'an, Shaanxi, China.
FAU - Xin, Jialun
AU  - Xin J
AD  - Department of Neurology, Xijing Hospital, the Fourth Military Medical University, 
      Xi'an, Shaanxi, China.
FAU - Cao, Ruili
AU  - Cao R
AD  - Department of Neurology, Xijing Hospital, the Fourth Military Medical University, 
      Xi'an, Shaanxi, China.
FAU - Liu, Zhirong
AU  - Liu Z
AD  - Department of Neurology, Xijing Hospital, the Fourth Military Medical University, 
      Xi'an, Shaanxi, China. Electronic address: liuzhir@fmmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200416
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Biomarkers)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (neurofilament protein L)
SB  - IM
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/diagnosis/physiopathology/therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Neurofilament Proteins/*blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Recurrence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stroke/*blood/diagnosis/physiopathology/therapy
MH  - Time Factors
OTO - NOTNLM
OT  - Neurofilament light chain
OT  - meta-analysis
OT  - outcome
OT  - prognostic factor
OT  - stroke
COIS- Conflict of Interest The authors declare that they have no conflict of interest.
EDAT- 2020/04/20 06:00
MHDA- 2020/09/30 06:00
CRDT- 2020/04/20 06:00
PHST- 2019/12/13 00:00 [received]
PHST- 2020/03/13 00:00 [accepted]
PHST- 2020/04/20 06:00 [pubmed]
PHST- 2020/09/30 06:00 [medline]
PHST- 2020/04/20 06:00 [entrez]
AID - S1052-3057(20)30197-X [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2020.104813 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2020 Jun;29(6):104813. doi: 
      10.1016/j.jstrokecerebrovasdis.2020.104813. Epub 2020 Apr 16.