PMID- 32306191
OWN - NLM
STAT- MEDLINE
DCOM- 20201215
LR  - 20201215
IS  - 1613-2254 (Electronic)
IS  - 1346-4523 (Linking)
VI  - 47
IP  - 3
DP  - 2020 Jul
TI  - Key factors of diastolic dysfunction and abnormal left ventricular relaxation in 
      diabetic rats.
PG  - 347-356
LID - 10.1007/s10396-020-01021-x [doi]
AB  - PURPOSE: To study the diastolic functions using color Doppler M-mode (CDMM) for 
      noninvasive analysis of the intraventricular pressure difference (IVPD) in 
      diabetic rats. METHODS: Two equal groups of rats were included: control and 
      streptozotocin-induced DM (n = 15). The cardiac functions were examined monthly 
      using conventional echocardiography and CDMM with a specific MATLAB software. 
      Echocardiography was performed under 2% isoflurane mask inhalation. Five months 
      thereafter, all rats were killed for macroscopic and microscopic examinations of 
      the cardiac fibrosis. RESULTS: DM rats showed higher systolic blood pressure and 
      diastolic dysfunction, i.e., decreases in several parameters such as E, E/A, 
      TDIs, and IVPDs, compared to the controls. Moreover, obvious cardiac fibrosis was 
      seen in perivascular and interstitial tissues, but there were no notable 
      differences in terms of gross lesions. CONCLUSIONS: Because of the noninvasive 
      nature of CDMM, IVPD and other conventional echocardiographic parameters can be 
      used as reliable indicators generally for evaluating cardiac function and 
      particularly the change in intraventricular pressure.
FAU - Kitpipatkun, Pitipat
AU  - Kitpipatkun P
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology, Tokyo, Japan.
FAU - Matsuura, Katsuhiro
AU  - Matsuura K
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology, Tokyo, Japan.
FAU - Shimada, Kazumi
AU  - Shimada K
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology, Tokyo, Japan.
FAU - Uemura, Akiko
AU  - Uemura A
AD  - Animal Medical Centor, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
FAU - Goya, Seijirow
AU  - Goya S
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology, Tokyo, Japan.
FAU - Yoshida, Tomohiko
AU  - Yoshida T
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology, Tokyo, Japan.
FAU - Ma, Danfu
AU  - Ma D
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology, Tokyo, Japan.
FAU - Takahashi, Ken
AU  - Takahashi K
AD  - Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate 
      School of Medicine, Tokyo, Japan.
FAU - Tanaka, Ryou
AU  - Tanaka R
AD  - Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo 
      University of Agriculture and Technology, Tokyo, Japan. ryo@vet.ne.jp.
LA  - eng
PT  - Journal Article
DEP - 20200418
PL  - Japan
TA  - J Med Ultrason (2001)
JT  - Journal of medical ultrasonics (2001)
JID - 101128385
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*complications/*physiopathology
MH  - Diastole/physiology
MH  - Disease Models, Animal
MH  - Echocardiography, Doppler, Color/*methods
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ventricular Dysfunction, Left/complications/*diagnostic imaging/*physiopathology
OTO - NOTNLM
OT  - Diabetes
OT  - Echocardiography
OT  - Intraventricular pressure difference
OT  - Rats
OT  - Streptozotocin
EDAT- 2020/04/20 06:00
MHDA- 2020/12/16 06:00
CRDT- 2020/04/20 06:00
PHST- 2019/11/01 00:00 [received]
PHST- 2020/03/08 00:00 [accepted]
PHST- 2020/04/20 06:00 [pubmed]
PHST- 2020/12/16 06:00 [medline]
PHST- 2020/04/20 06:00 [entrez]
AID - 10.1007/s10396-020-01021-x [pii]
AID - 10.1007/s10396-020-01021-x [doi]
PST - ppublish
SO  - J Med Ultrason (2001). 2020 Jul;47(3):347-356. doi: 10.1007/s10396-020-01021-x. 
      Epub 2020 Apr 18.