PMID- 32306805
OWN - NLM
STAT- MEDLINE
DCOM- 20210604
LR  - 20210604
IS  - 1549-781X (Electronic)
IS  - 1040-8363 (Linking)
VI  - 57
IP  - 7
DP  - 2020 Nov
TI  - Perspectives on the role of PTEN in diabetic nephropathy: an update.
PG  - 470-483
LID - 10.1080/10408363.2020.1746735 [doi]
AB  - Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor gene that 
      antagonizes the proto-oncogenic phosphatidylinositol 3 kinase (PI3K)/protein 
      kinase B (Akt) signaling pathway and governs basic cellular metabolic processes. 
      Recently, its role in cell growth, metabolism, architecture, and motility as an 
      intramolecular and regulatory mediator has gained widespread research interest as 
      it applies to non-tumorous diseases, such as insulin resistance (IR) and diabetic 
      nephropathy (DN). DN is characterized by renal tubulointerstitial fibrosis (TIF) 
      and epithelial-mesenchymal transition (EMT), and PTEN plays a significant role in 
      the regulation of both. Epigenetics and microRNAs (miRNAs) are novel players in 
      post-transcriptional regulation and research evidence demonstrates that they 
      reduce the expression of PTEN by acting as key regulators of autophagy and TIF 
      through activation of the Akt/mammalian target of rapamycin (mTOR) signaling 
      pathway. These regulatory processes might play an important role in solving the 
      complexities of DN pathogenesis and IR, as well as the therapeutic management of 
      DN with the help of PTEN K27-linked polyubiquitination. Currently, there are no 
      comprehensive reviews citing the role PTEN plays in the development of DN and its 
      regulation via miRNA and epigenetic modifications. The present review explores 
      these facets of PTEN in the pathogenesis of IR and DN.
FAU - Khokhar, Manoj
AU  - Khokhar M
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Roy, Dipayan
AU  - Roy D
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Modi, Anupama
AU  - Modi A
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Agarwal, Riddhi
AU  - Agarwal R
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Yadav, Dharmveer
AU  - Yadav D
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Purohit, Purvi
AU  - Purohit P
AUID- ORCID: 0000-0001-8559-2911
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Sharma, Praveen
AU  - Sharma P
AUID- ORCID: 0000-0002-8324-737X
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200420
PL  - England
TA  - Crit Rev Clin Lab Sci
JT  - Critical reviews in clinical laboratory sciences
JID - 8914816
RN  - 0 (MicroRNAs)
RN  - EC 2.7.11.1 (AKT1 protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Autophagy/genetics
MH  - Diabetic Nephropathies/*metabolism/physiopathology
MH  - Epigenesis, Genetic/genetics
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Female
MH  - Fibrosis/genetics
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Male
MH  - MicroRNAs/genetics
MH  - PTEN Phosphohydrolase/genetics/*metabolism/physiology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - EMT
OT  - PI3K
OT  - Type 2 diabetes mellitus
OT  - insulin resistance
EDAT- 2020/04/21 06:00
MHDA- 2021/06/05 06:00
CRDT- 2020/04/21 06:00
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2021/06/05 06:00 [medline]
PHST- 2020/04/21 06:00 [entrez]
AID - 10.1080/10408363.2020.1746735 [doi]
PST - ppublish
SO  - Crit Rev Clin Lab Sci. 2020 Nov;57(7):470-483. doi: 
      10.1080/10408363.2020.1746735. Epub 2020 Apr 20.