PMID- 32307218
OWN - NLM
STAT- MEDLINE
DCOM- 20201119
LR  - 20201119
IS  - 1532-2130 (Electronic)
IS  - 1090-3798 (Linking)
VI  - 27
DP  - 2020 Jul
TI  - Feasibility & safety of plasma exchange in paediatric neuro-immunology: A single 
      center experience.
PG  - 94-97
LID - S1090-3798(20)30072-6 [pii]
LID - 10.1016/j.ejpn.2020.04.001 [doi]
AB  - BACKGROUND: There is limited data available on the safety of therapeutic plasma 
      exchange (TPE) for paediatric neuro-immunological disorders (PNID). In this 
      study, we report our data on safety and feasibility of TPE for these disorders. 
      METHODS: Retrospective chart review was performed to include all patient who 
      received TPE for four major PNID conditions: autoimmune encephalitis (AIE), acute 
      disseminated encephalomyelitis (ADEM), Neuromyelitis optic spectrum disorder 
      (NMOSD) and transverse myelitis (TM). We recorded minor and major adverse effects 
      (AEs) associated with each TPE procedure. Secondary analysis also looked at the 
      efficacy data of TPE on these patients. RESULTS: Thirty-two patients with PNID 
      received a total of 186 TPE cycles. Out of these, only 1 cycle (0.89%) in AIE 
      subgroup, 1 (4.3%) in NMOSD and 1 (4.5%) in TM had adverse effects. No patients 
      had major side effects. CONCLUSION: TPE was safe and well tolerated in our PNID 
      patients.
CI  - Copyright (c) 2020 European Paediatric Neurology Society. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Shah, Yash D
AU  - Shah YD
AD  - Division of Child Neurology, Department of Pediatrics, Cohen Children's Medical 
      Center, New Hyde Park, NY, USA.
FAU - Eksambe, Padmavati
AU  - Eksambe P
AD  - Division of Child Neurology, Department of Pediatrics, Cohen Children's Medical 
      Center, New Hyde Park, NY, USA.
FAU - Fomani, Katayoun
AU  - Fomani K
AD  - Division of Transfusion Medicine Service Northwell Health, Cohen Children's 
      Medical Center, New Hyde Park, NY, USA.
FAU - Louie, James
AU  - Louie J
AD  - Division of Transfusion Medicine Service Northwell Health, Cohen Children's 
      Medical Center, New Hyde Park, NY, USA.
FAU - Shefali, Karkare
AU  - Shefali K
AD  - Division of Child Neurology, Department of Pediatrics, Cohen Children's Medical 
      Center, New Hyde Park, NY, USA.
FAU - Kothare, Sanjeev
AU  - Kothare S
AD  - Division of Child Neurology, Department of Pediatrics, Cohen Children's Medical 
      Center, New Hyde Park, NY, USA. Electronic address: skothare@northwell.edu.
LA  - eng
PT  - Journal Article
DEP - 20200410
PL  - England
TA  - Eur J Paediatr Neurol
JT  - European journal of paediatric neurology : EJPN : official journal of the 
      European Paediatric Neurology Society
JID - 9715169
RN  - Hashimoto's encephalitis
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Encephalitis/*therapy
MH  - Encephalomyelitis, Acute Disseminated/*therapy
MH  - Feasibility Studies
MH  - Female
MH  - Hashimoto Disease/*therapy
MH  - Humans
MH  - Infant
MH  - Male
MH  - Myelitis, Transverse/*therapy
MH  - Neuromyelitis Optica/*therapy
MH  - Plasma Exchange/adverse effects/*methods
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Paediatric neuro-immunological disorders (PNID)
OT  - Therapeutic plasma exchange (TPE)
COIS- Declaration of competing interest The authors have no conflicts of interest to 
      declare.
EDAT- 2020/04/21 06:00
MHDA- 2020/11/20 06:00
CRDT- 2020/04/21 06:00
PHST- 2019/11/11 00:00 [received]
PHST- 2020/02/10 00:00 [revised]
PHST- 2020/04/04 00:00 [accepted]
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2020/04/21 06:00 [entrez]
AID - S1090-3798(20)30072-6 [pii]
AID - 10.1016/j.ejpn.2020.04.001 [doi]
PST - ppublish
SO  - Eur J Paediatr Neurol. 2020 Jul;27:94-97. doi: 10.1016/j.ejpn.2020.04.001. Epub 
      2020 Apr 10.