PMID- 32307566
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20200601
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 99
IP  - 6
DP  - 2020 Jun
TI  - Clinical characteristics and outcomes of oligosecretory and non-secretory 
      multiple myeloma.
PG  - 1251-1255
LID - 10.1007/s00277-020-03984-w [doi]
AB  - Secretion of monoclonal immunoglobulins (MIg) detected in the serum and/or urine 
      is one of the typical features of multiple myeloma (MM). However, some patients 
      secrete MIg in quantities below "measurable" (termed oligosecretory MM) and 
      others have no detectable MIgs by standard serum and urine immunofixation (termed 
      non-secretory MM). In a cohort of 852 consecutive patients with active myeloma, 
      we identified 100 (11.7%) patients with oligo/non-secretory MM, including 20 
      (2.3%) with non-secretory MM. Compared to patients with secretory MM, these were 
      younger, less anemic, and had less often renal dysfunction and less extensive 
      bone marrow infiltration. Presence and extent of bone disease were similar, 
      however, hypercalcemia was less common and more often is ISS (International 
      Staging System)-1 and, in those with available FISH (Fluoresense In Situ 
      Hybridization) , high-risk cytogenetics were less common. FLCs (Free Light 
      Chains) were available in 17 patients with non-secretory MM: only 3 had normal 
      FLC ratio; the others had abnormal ratio and 9/14 had involved FLC >/= 100 mg/L. 
      The 4-year OS for patients with oligo/non-secretory disease was 64% vs 58% for 
      secretory MM. In multivariate analysis, oligo/non-secretory disease was not an 
      independent prognostic factor per se. Thus, 12% of MM patients present with 
      oligo/non-secretory disease at diagnosis and have different biologic 
      characteristics but similar outcome to other MM patients.
FAU - Migkou, Magdalini
AU  - Migkou M
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Avivi, Irit
AU  - Avivi I
AD  - Hematology division, Tel Aviv Sourasky Medical Center, Sackler faculty of 
      medicine, Tel Aviv University, 6 Weizmann Street, 6423906, Tel Aviv, Israel.
FAU - Gavriatopoulou, Maria
AU  - Gavriatopoulou M
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Cohen, Yael C
AU  - Cohen YC
AD  - Hematology division, Tel Aviv Sourasky Medical Center, Sackler faculty of 
      medicine, Tel Aviv University, 6 Weizmann Street, 6423906, Tel Aviv, Israel.
FAU - Fotiou, Despina
AU  - Fotiou D
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Kanellias, Nikolaos
AU  - Kanellias N
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Ziogas, Dimitrios
AU  - Ziogas D
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Eleutherakis-Papaiakovou, Evangelos
AU  - Eleutherakis-Papaiakovou E
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Terpos, Evangelos
AU  - Terpos E
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Roussou, Maria
AU  - Roussou M
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Kastritis, Efstathios
AU  - Kastritis E
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
FAU - Dimopoulos, Meletios A
AU  - Dimopoulos MA
AD  - Department of Clinical Therapeutics, Alexandra Hospital, National and 
      Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece. 
      mdimop@med.uoa.gr.
LA  - eng
PT  - Journal Article
DEP - 20200419
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin Light Chains)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood/urine
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin Light Chains/*blood/*urine
MH  - Immunoglobulin M/*blood/*urine
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*blood/therapy/*urine
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Free light chains
OT  - Hypercalcemia
OT  - Immunoglobulins
OT  - Prognosis
EDAT- 2020/04/21 06:00
MHDA- 2020/06/02 06:00
CRDT- 2020/04/21 06:00
PHST- 2019/06/19 00:00 [received]
PHST- 2020/03/01 00:00 [accepted]
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2020/04/21 06:00 [entrez]
AID - 10.1007/s00277-020-03984-w [pii]
AID - 10.1007/s00277-020-03984-w [doi]
PST - ppublish
SO  - Ann Hematol. 2020 Jun;99(6):1251-1255. doi: 10.1007/s00277-020-03984-w. Epub 2020 
      Apr 19.