PMID- 32308013
OWN - NLM
STAT- MEDLINE
DCOM- 20200827
LR  - 20200827
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 48
IP  - 3
DP  - 2020
TI  - Magnoliae Flos Essential Oil as an Immunosuppressant in Dendritic Cell Activation 
      and Contact Hypersensitivity Responses.
PG  - 597-613
LID - 10.1142/S0192415X20500305 [doi]
AB  - Magnoliae Flos is a commonly used traditional medicinal material in Asia. It is 
      used to treat sinusitis, nasal congestion, and hypersensitive skin. Because 
      Magonlia Flos was described as an aromatic material in ancient Chinese texts, we 
      hypothesized that its essential oil may be used to treat immune disorders. 
      Dendritic cells (DCs), regarded as a major target of immunomodulators to control 
      immune responses, play a critical role in the adaptive immune response. In this 
      study, Magnoliae Flos essential oil (MFEO) decreased the production of the 
      cytokines TNF-alpha, IL-6, and IL-12p70 in lipopolysaccharide (LPS)-stimulated DCs. 
      It also suppressed the surface markers MHC II, CD80, and CD86 in LPS-stimulated 
      DCs. Animal models demonstrated that the 2,4-Dinitro-1-fluorobenzene (DNFB) 
      inducing a contact hypersensitivity response was inhibited following treatment 
      with MFEO. In addition, MFEO inhibited the infiltration of T cells in the ears of 
      DNFB-induced mice. To explore its bioactive compounds, the components of MFEO 
      were analyzed using gas chromatography (GC) and GC-mass spectrometry. The results 
      revealed that the major compounds in MFEO are camphor and 1,8-cineole. Additional 
      DC bioassays confirmed that these compounds substantially suppressed cytokine 
      production in LPS-induced DCs. Therefore, we demonstrated that MFEO exhibits an 
      immunosuppressive effect both in vivo and in vitro, and camphor and 1,8-cineole 
      may be the major components responsible for its immunosuppressive ability. The 
      findings indicate that MFEO has the potential to be developed as a new 
      immunosuppressant for excessive diseases.
FAU - Chen, Chun-Hsien
AU  - Chen CH
AD  - Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, 
      College of Chinese Medicine, National Cheng Kung University, Tainan, Taiwan.
AD  - Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Chen, Hsin-Chun
AU  - Chen HC
AD  - Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China 
      Medical University, Taichung, Taiwan.
FAU - Chang, Wen-Te
AU  - Chang WT
AD  - Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, 
      College of Chinese Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Lee, Meng-Shiou
AU  - Lee MS
AD  - Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, 
      College of Chinese Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Liu, Yi-Chen
AU  - Liu YC
AD  - Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, 
      College of Chinese Medicine, National Cheng Kung University, Tainan, Taiwan.
AD  - Institute of Medical Technology, College of Life Science, National Chung Hsing 
      University, Taichung, Taiwan.
FAU - Lin, Ming-Kuem
AU  - Lin MK
AD  - Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, 
      College of Chinese Medicine, National Cheng Kung University, Tainan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20200417
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Cytokines)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Oils, Volatile)
RN  - 76-22-2 (Camphor)
RN  - RV6J6604TK (Eucalyptol)
SB  - IM
MH  - Adaptive Immunity/*drug effects
MH  - Animals
MH  - Camphor/analysis/isolation & purification
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Dermatitis, Contact/*drug therapy/*immunology
MH  - Disease Models, Animal
MH  - Eucalyptol/analysis/isolation & purification
MH  - *Immunosuppressive Agents
MH  - Magnoliaceae/*chemistry
MH  - Mice
MH  - Oils, Volatile/chemistry/*pharmacology/*therapeutic use
MH  - *Phytotherapy
MH  - T-Lymphocytes/immunology
OTO - NOTNLM
OT  - Contact Hypersensitivity Response
OT  - Dendritic Cells
OT  - Essential Oil
OT  - Magnoliae Flos
EDAT- 2020/04/21 06:00
MHDA- 2020/08/28 06:00
CRDT- 2020/04/21 06:00
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2020/08/28 06:00 [medline]
PHST- 2020/04/21 06:00 [entrez]
AID - 10.1142/S0192415X20500305 [doi]
PST - ppublish
SO  - Am J Chin Med. 2020;48(3):597-613. doi: 10.1142/S0192415X20500305. Epub 2020 Apr 
      17.