PMID- 32308456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 13
DP  - 2020
TI  - Resveratrol Prevents Cognitive Impairment in Type 2 Diabetic Mice by Upregulating 
      Nrf2 Expression and Transcriptional Level.
PG  - 1061-1075
LID - 10.2147/DMSO.S243560 [doi]
AB  - PURPOSE: This study aimed to determine whether the natural antioxidant 
      resveratrol (RSV) prevents type 2 diabetes mellitus (T2DM)-induced cognitive 
      impairment and to explore whether redox-associated factor nuclear factor 
      erythroid 2-related factor 2 (Nrf2) plays a critical role in the neuroprotective 
      effect of RSV. MATERIALS AND METHODS: We established a T2DM model with 8-week-old 
      male ICR mice by administration of a high-fat diet for 2 months and low-dose 
      streptozotocin for 3 days. Then, diabetic and age-matched control mice were 
      treated with or without RSV for 4 months every other day and subjected to the 
      Morris water maze test. After the mice were euthanized, whole brains were 
      sectioned for Nissl staining and immunofluorescence labeling. Hippocampal 
      sections were observed by transmission electron microscopy to evaluate the 
      ultrastructure of synapses. Inflammatory factors, oxidative stress-related 
      indexes, and Nrf2 and downstream target gene expression were analyzed in 
      hippocampal tissues by quantitative real-time PCR, Western blotting, and 
      associated quantitative kits. RESULTS: In the Morris water maze test, compared to 
      control mice, T2DM mice showed learning and memory impairments, but RSV treatment 
      prevented the learning and memory decline in T2DM mice. Similarly, RSV prevented 
      T2DM-induced hippocampal neuron destruction and synaptic ultrastructural damage. 
      The expression levels of inflammatory factors and oxidative stress-related 
      indicators were increased in the T2DM group compared with the control group but 
      were decreased significantly by RSV treatment in the T2DM group. Additionally, 
      the expression of Nrf2 and its downstream target genes was decreased in the T2DM 
      group compared with the control group and was significantly increased by RSV 
      treatment in the T2DM group. CONCLUSION: RSV prevented T2DM-induced cognitive 
      impairment through anti-inflammatory and antioxidant activities. This effect was 
      accompanied by the upregulation of Nrf2 transcriptional activity and the 
      increased expression of downstream antioxidant genes.
CI  - (c) 2020 Wang et al.
FAU - Wang, Xiaoxiao
AU  - Wang X
AUID- ORCID: 0000-0002-4458-9166
AD  - Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 
      050017, People's Republic of China.
FAU - Fang, Hui
AU  - Fang H
AD  - Second Department of Endocrinology, Tangshan Gongren Hospital, Tangshan, Hebei 
      063000, People's Republic of China.
FAU - Xu, Gang
AU  - Xu G
AD  - Department of Burns and Orthopedics, Tangshan Gongren Hospital, Tangshan, Hebei 
      063000, People's Republic of China.
FAU - Yang, Ying
AU  - Yang Y
AD  - Second Department of Endocrinology, Tangshan Gongren Hospital, Tangshan, Hebei 
      063000, People's Republic of China.
FAU - Xu, Ruizhe
AU  - Xu R
AD  - Department of Clinical Medicine, Tangshan Vocational and Technical College, 
      Tangshan, Hebei, 063000, People's Republic of China.
FAU - Liu, Qiang
AU  - Liu Q
AD  - Department of Internal Medicine, North China University of Science and 
      Technology, Tangshan, Hebei 063000, People's Republic of China.
FAU - Xue, Xiangyu
AU  - Xue X
AD  - Department of Internal Medicine, North China University of Science and 
      Technology, Tangshan, Hebei 063000, People's Republic of China.
FAU - Liu, Jiaqi
AU  - Liu J
AD  - Department of Internal Medicine, North China University of Science and 
      Technology, Tangshan, Hebei 063000, People's Republic of China.
FAU - Wang, Hezhi
AU  - Wang H
AUID- ORCID: 0000-0002-3194-8086
AD  - Department of Surgery, Hebei Medical University, Shijiazhuang 050017, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200407
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
EIN - Diabetes Metab Syndr Obes. 2020 Jun 17;13:2057. PMID: 32606864
PMC - PMC7150671
OTO - NOTNLM
OT  - Nrf2 activator
OT  - inflammation
OT  - natural antioxidant
OT  - oxidative stress
COIS- The authors report that there are no potential conflicts of interest associated 
      with this article.
EDAT- 2020/04/21 06:00
MHDA- 2020/04/21 06:01
PMCR- 2020/04/07
CRDT- 2020/04/21 06:00
PHST- 2019/12/24 00:00 [received]
PHST- 2020/03/26 00:00 [accepted]
PHST- 2020/04/21 06:00 [entrez]
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2020/04/21 06:01 [medline]
PHST- 2020/04/07 00:00 [pmc-release]
AID - 243560 [pii]
AID - 10.2147/DMSO.S243560 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2020 Apr 7;13:1061-1075. doi: 10.2147/DMSO.S243560. 
      eCollection 2020.