PMID- 32308655
OWN - NLM
STAT- MEDLINE
DCOM- 20210326
LR  - 20210326
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - Phthalate Exposure During the Prenatal and Lactational Period Increases the 
      Susceptibility to Rheumatoid Arthritis in Mice.
PG  - 550
LID - 10.3389/fimmu.2020.00550 [doi]
LID - 550
AB  - The prenatal and early postnatal period is highly sensitive to environmental 
      exposures that may interfere with the developmental programming of the immune 
      system leading to an altered disease risk in later life. To clarify the role of 
      early influences in activation or exacerbation of autoimmune diseases like 
      rheumatoid arthritis (RA) we investigated the effect of maternal exposure during 
      the prenatal and lactational period of DBA/1 mice to the plasticizer benzyl butyl 
      phthalate (BBP) on the development of RA in the offspring. Using a mild 
      collagen-induced arthritis (CIA) model, maternal BBP-exposure increased both the 
      prevalence and the severity of RA in the progeny compared to un-exposed dams. 
      Additionally, maternal BBP exposure led to elevated serum IgG(1) and IgG(2a) 
      level in the offspring and increased the IFN-gamma and IL-17 release from 
      collagen-re-stimulated spleen cells. Transcriptome analysis of splenocytes 
      isolated from 3-week-old pups before RA-induction revealed considerable changes 
      in gene expression in the offspring from BBP-exposed dams. Among them were 
      regulator of G-protein signaling 1 (rgs1), interleukin-7 receptor (il-7r) and CXC 
      chemokine 4 (cxcr4), all genes that have previously been described as associated 
      with RA pathology. In summary, our results demonstrate that perinatal exposure to 
      BBP increases the susceptibility of the offspring to RA, probably via a 
      phthalate-induced disturbed regulation of RA-relevant genes or signaling 
      pathways.
CI  - Copyright (c) 2020 Elter, Wagner, Buchenauer, Bauer and Polte.
FAU - Elter, Elena
AU  - Elter E
AD  - Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental 
      Research Leipzig-Halle, Leipzig, Germany.
AD  - Department of Dermatology, Venerology and Allergology, Leipzig University Medical 
      Center, Leipzig, Germany.
FAU - Wagner, Marita
AU  - Wagner M
AD  - Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental 
      Research Leipzig-Halle, Leipzig, Germany.
AD  - Department of Dermatology, Venerology and Allergology, Leipzig University Medical 
      Center, Leipzig, Germany.
FAU - Buchenauer, Lisa
AU  - Buchenauer L
AD  - Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental 
      Research Leipzig-Halle, Leipzig, Germany.
AD  - Department of Dermatology, Venerology and Allergology, Leipzig University Medical 
      Center, Leipzig, Germany.
FAU - Bauer, Mario
AU  - Bauer M
AD  - Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental 
      Research Leipzig-Halle, Leipzig, Germany.
FAU - Polte, Tobias
AU  - Polte T
AD  - Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental 
      Research Leipzig-Halle, Leipzig, Germany.
AD  - Department of Dermatology, Venerology and Allergology, Leipzig University Medical 
      Center, Leipzig, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200403
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Phthalic Acids)
RN  - YPC4PJX59M (butylbenzyl phthalate)
SB  - IM
MH  - Animals
MH  - *Arthritis, Experimental/chemically induced
MH  - *Arthritis, Rheumatoid/chemically induced
MH  - Disease Susceptibility
MH  - Female
MH  - Lactation
MH  - Maternal Exposure/*adverse effects
MH  - Mice
MH  - Phthalic Acids/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
PMC - PMC7145968
OTO - NOTNLM
OT  - autoimmune disease
OT  - early programming
OT  - perinatal exposure
OT  - phthalates
OT  - rheumatoid arthritis
EDAT- 2020/04/21 06:00
MHDA- 2021/03/27 06:00
PMCR- 2020/01/01
CRDT- 2020/04/21 06:00
PHST- 2019/12/06 00:00 [received]
PHST- 2020/03/10 00:00 [accepted]
PHST- 2020/04/21 06:00 [entrez]
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2021/03/27 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.00550 [doi]
PST - epublish
SO  - Front Immunol. 2020 Apr 3;11:550. doi: 10.3389/fimmu.2020.00550. eCollection 
      2020.