PMID- 32308985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2052-0492 (Print)
IS  - 2052-0492 (Electronic)
IS  - 2052-0492 (Linking)
VI  - 8
DP  - 2020
TI  - Serial change of neutrophil extracellular traps in tracheal aspirate of patients 
      with acute respiratory distress syndrome: report of three cases.
PG  - 25
LID - 10.1186/s40560-020-00444-5 [doi]
LID - 25
AB  - BACKGROUND: Neutrophil extracellular traps (NETs) are fibrous structures released 
      from activated neutrophils. NET formation has been reported to be associated with 
      acute respiratory distress syndrome (ARDS). However, there are no reports dealing 
      with serial changes of NET formation in tracheal aspirate of ARDS patients. CASE 
      PRESENTATION: We report three cases of ARDS. Case 1 is a 69-year-old man with 
      necrotizing fasciitis of the buttocks, case 2 is a 49-year-old woman with 
      extensive burns (80% of total body surface), and case 3 is a 73-year-old woman 
      with severe bacterial pneumonia. We found abundant expression of citrullinated 
      histone H3 (Cit-H3) and the formation of NETs at the onset of ARDS in all cases. 
      The amounts of Cit-H3 and NETs decreased with the amelioration of respiratory 
      failure in cases 1 and 2. In case 2, the amounts of Cit-H3 and NETs increased 
      with aggravation of infection and respiratory status. In case 3, the abundant 
      expression of Cit-H3 and NETs persisted; the patient did not recover from ARDS 
      and eventually died. Cit-H3 and NETs were found in tracheal aspirates even if the 
      patients had no direct injury to the lung as in cases 1 and 2. CONCLUSIONS: In 
      these three cases, the formation of NETs was observed in tracheal aspirate of 
      patients with ARDS by either direct or indirect insults to the lung. The amount 
      of NET formation changed dynamically over the clinical course of each patient.
CI  - (c) The Author(s) 2020.
FAU - Ojima, Masahiro
AU  - Ojima M
AD  - 1Department of Traumatology and Acute Critical Medicine, Osaka University 
      Graduate School of Medicine, Suita, Osaka, Japan. GRID: grid.136593.b. ISNI: 0000 
      0004 0373 3971
FAU - Yamamoto, Norihisa
AU  - Yamamoto N
AD  - 2Division of Infection Control and Prevention, Osaka University Hospital, Suita, 
      Osaka, Japan. GRID: grid.412398.5. ISNI: 0000 0004 0403 4283
FAU - Hirose, Tomoya
AU  - Hirose T
AD  - 1Department of Traumatology and Acute Critical Medicine, Osaka University 
      Graduate School of Medicine, Suita, Osaka, Japan. GRID: grid.136593.b. ISNI: 0000 
      0004 0373 3971
FAU - Hamaguchi, Shigeto
AU  - Hamaguchi S
AD  - 2Division of Infection Control and Prevention, Osaka University Hospital, Suita, 
      Osaka, Japan. GRID: grid.412398.5. ISNI: 0000 0004 0403 4283
FAU - Tasaki, Osamu
AU  - Tasaki O
AD  - 3Acute and Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan. 
      GRID: grid.411873.8. ISNI: 0000 0004 0616 1585
FAU - Kojima, Takashi
AU  - Kojima T
AD  - 4Central Laboratory for Clinical Investigation, Osaka University Hospital, Suita, 
      Osaka, Japan. GRID: grid.412398.5. ISNI: 0000 0004 0403 4283
FAU - Tomono, Kazunori
AU  - Tomono K
AD  - 2Division of Infection Control and Prevention, Osaka University Hospital, Suita, 
      Osaka, Japan. GRID: grid.412398.5. ISNI: 0000 0004 0403 4283
FAU - Ogura, Hiroshi
AU  - Ogura H
AD  - 1Department of Traumatology and Acute Critical Medicine, Osaka University 
      Graduate School of Medicine, Suita, Osaka, Japan. GRID: grid.136593.b. ISNI: 0000 
      0004 0373 3971
FAU - Shimazu, Takeshi
AU  - Shimazu T
AD  - 1Department of Traumatology and Acute Critical Medicine, Osaka University 
      Graduate School of Medicine, Suita, Osaka, Japan. GRID: grid.136593.b. ISNI: 0000 
      0004 0373 3971
LA  - eng
PT  - Case Reports
DEP - 20200410
PL  - England
TA  - J Intensive Care
JT  - Journal of intensive care
JID - 101627304
PMC - PMC7149861
OTO - NOTNLM
OT  - Acute respiratory distress syndrome (ARDS)
OT  - Citrullinated histone
OT  - Histone
OT  - Neutrophil extracellular traps (NETs)
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2020/04/21 06:00
MHDA- 2020/04/21 06:01
PMCR- 2020/04/10
CRDT- 2020/04/21 06:00
PHST- 2020/01/07 00:00 [received]
PHST- 2020/04/01 00:00 [accepted]
PHST- 2020/04/21 06:00 [entrez]
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2020/04/21 06:01 [medline]
PHST- 2020/04/10 00:00 [pmc-release]
AID - 444 [pii]
AID - 10.1186/s40560-020-00444-5 [doi]
PST - epublish
SO  - J Intensive Care. 2020 Apr 10;8:25. doi: 10.1186/s40560-020-00444-5. eCollection 
      2020.