PMID- 32311193
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 53
IP  - 1
DP  - 2021 Jan
TI  - Biventricular Reference Values by Body Surface Area, Age, and Gender in a Large 
      Cohort of Well-Treated Thalassemia Major Patients Without Heart Damage Using a 
      Multiparametric CMR Approach.
PG  - 61-70
LID - 10.1002/jmri.27169 [doi]
AB  - BACKGROUND: Cardiac MRI plays a critical role in the management of thalassemic 
      patients. No accurate biventricular reference values are available. PURPOSE: To 
      establish the ranges for normal left ventricular (LV) and right ventricular (RV) 
      volumes and ejection fraction (EF) and LV mass normalized to body surface area 
      (BSA), age, and gender in a large cohort of well-treated beta-thalassemia major 
      (beta-TM) patients without heart damage using a multiparametric MRI. STUDY TYPE: 
      Retrospective/cohort study. POPULATION: In all, 251 beta-TM patients with no known 
      risk factors or cardiac disease, normal electrocardiogram, no macroscopic 
      myocardial fibrosis, and all cardiac segments with T(2) * >/=20 msec, and 246 
      healthy subjects. FIELD STRENGTH/SEQUENCE: 1.5T/cine steady-state free precession 
      (SSFP), gradient-echo T(2) *, late gadolinium enhancement (LGE) images. 
      ASSESSMENT: Biventricular end-diastolic volume, end-systolic volume, stroke 
      volume, and LV mass were normalized to BSA (EDVI, ESVI, SVI). STATISTICAL TESTS: 
      Comparisons between the two groups was performed with two-samples t-test or 
      Wilcoxon's signed rank test. For more than two groups, one-way analysis of 
      variance (ANOVA) or a Kruskal-Wallis test were applied. RESULTS: Compared to 
      controls, males with beta-TM showed significantlt higher LVEDVI in all the age 
      groups, while for the other volumes the difference was significant only within 
      one or more age groups. In females the volumes were comparable between beta-TM 
      patients and healthy subjects in all the age groups. In the male beta-TM population 
      we found a significant effect of age on LVEDVI (P = 0.017), LVESVI (P = 0.001), 
      RVESVI (P = 0.029), and RVEF (P = 0.031), while for females none of the 
      biventricular parameters were significantly different among the age groups 
      (LVEDVI: P = 0.614; LVESVI: P = 0.449; LVSVI: P = 0.186; LV mass index: P = 
      0.071; LVEF: P = 0.059; RVEDVI: P = 0.374; RVESVI: P = 0.180; RVSVI: P = 0.206; 
      RVEF: P = 0.057). In beta-TM patients all biventricular volume indexes as well as 
      the LV mass index were significantly larger in males than in females (P < 0.0001 
      in all cases). The LV and the RV EF were comparable between the sexes (P = 0.568 
      and P = 0.268, respectively). DATA CONCLUSION: Appropriate "normal" reference 
      ranges normalized to BSA, sex, and age are recommended to avoid misdiagnosis of 
      cardiomyopathy in beta-TM patients. LEVEL OF EVIDENCE: 4 TECHNICAL EFFICACY STAGE: 
      2.
CI  - (c) 2020 International Society for Magnetic Resonance in Medicine.
FAU - Meloni, Antonella
AU  - Meloni A
AUID- ORCID: 0000-0002-2284-8585
AD  - Magnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione Toscana, 
      Pisa, Italy.
FAU - Righi, Riccardo
AU  - Righi R
AD  - Diagnostica per Immagini e Radiologia Interventistica, Ospedale del Delta, 
      Lagosanto, Italy.
FAU - Missere, Massimiliano
AU  - Missere M
AD  - Dipartimento di Immagini, Fondazione di Ricerca e Cura "Giovanni Paolo II", 
      Campobasso, Italy.
FAU - Renne, Stefania
AU  - Renne S
AD  - Struttura Complessa di Cardioradiologia-UTIC, Presidio Ospedaliero "Giovanni 
      Paolo II", Lamezia Terme, Italy.
FAU - Schicchi, Nicolo
AU  - Schicchi N
AD  - Dipartimento di Radiologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti 
      "Umberto I-Lancisi-Salesi", Ancona, Italy.
FAU - Gamberini, Maria Rita
AU  - Gamberini MR
AD  - Dipartimento della Riproduzione e dell'Accrescimento Day Hospital della 
      Talassemia e delle Emoglobinopatie, Azienda Ospedaliero-Universitaria Arcispedale 
      "S. Anna", Ferrara, Italy.
FAU - Cuccia, Liana
AU  - Cuccia L
AD  - Unita Operativa Complessa Ematologia con Talassemia, ARNAS Civico "Benfratelli-Di 
      Cristina", Palermo, Italy.
FAU - Lisi, Roberto
AU  - Lisi R
AD  - Unita Operativa Dipartimentale Talassemia, Presidio Ospedaliero 
      Garibaldi-Centro-ARNAS Garibaldi, Catania, Italy.
FAU - Spasiano, Anna
AU  - Spasiano A
AD  - Unita Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda 
      Ospedaliera di Rilievo Nazionale "A. Cardarelli", Naples, Italy.
FAU - Roberti, Maria Grazia
AU  - Roberti MG
AD  - Servizio Trasfusionale, Azienda Ospedaliero-Universitaria OO.RR. Foggia, Foggia, 
      Italy.
FAU - Zuccarelli, Angelo
AU  - Zuccarelli A
AD  - U.O. Medicina trasfusionale, Presidio Ospedaliero Sirai, Carbonia, Italy.
FAU - Ait-Ali, Lamia
AU  - Ait-Ali L
AUID- ORCID: 0000-0003-1672-5308
AD  - Institute of Clinical Physiology, National Research Council, Massa, Italy.
FAU - Festa, Pierluigi
AU  - Festa P
AD  - Magnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione Toscana, 
      Pisa, Italy.
AD  - Pediatric Cardiology and GUCH Unit, Fondazione G. Monasterio CNR-Regione Toscana, 
      Massa, Italy.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Magnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione Toscana, 
      Pisa, Italy.
FAU - Mangione, Maurizio
AU  - Mangione M
AD  - U.O.S. Sistemi informativi (UOSI), Fondazione G. Monasterio CNR-Regione Toscana, 
      Pisa, Italy.
FAU - Barra, Valerio
AU  - Barra V
AD  - Magnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione Toscana, 
      Pisa, Italy.
FAU - Positano, Vincenzo
AU  - Positano V
AUID- ORCID: 0000-0001-6955-9572
AD  - Magnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione Toscana, 
      Pisa, Italy.
FAU - Pepe, Alessia
AU  - Pepe A
AD  - Magnetic Resonance Imaging Unit, Fondazione G. Monasterio CNR-Regione Toscana, 
      Pisa, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200420
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Body Surface Area
MH  - Cohort Studies
MH  - Contrast Media
MH  - Female
MH  - Gadolinium
MH  - *Heart Injuries
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Reference Values
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - *beta-Thalassemia/diagnostic imaging
OTO - NOTNLM
OT  - beta-thalassemia major
OT  - biventricular function
OT  - reference values
EDAT- 2020/04/21 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/04/21 06:00
PHST- 2020/01/14 00:00 [received]
PHST- 2020/03/30 00:00 [revised]
PHST- 2020/03/30 00:00 [accepted]
PHST- 2020/04/21 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/04/21 06:00 [entrez]
AID - 10.1002/jmri.27169 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2021 Jan;53(1):61-70. doi: 10.1002/jmri.27169. Epub 2020 
      Apr 20.