PMID- 32314032
OWN - NLM
STAT- MEDLINE
DCOM- 20210413
LR  - 20210807
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 258
IP  - 7
DP  - 2020 Jul
TI  - Reduced photoreceptor outer segment layer thickness in mild commotio retinae 
      without ellipsoid zone disruption.
PG  - 1437-1442
LID - 10.1007/s00417-020-04678-9 [doi]
AB  - PURPOSE: To quantitatively investigate the reflectivity and structure of the 
      outer retinal layers on spectral-domain optical coherence tomography (SD-OCT) in 
      commotio retinae. METHODS: Nineteen patients with acute macular commotio retinae 
      and 19 age-matched normal controls were examined using SD-OCT. Longitudinal 
      reflectance profiles (LRP) were obtained using Image J. The reflectivity of outer 
      retinal layers was measured at the fovea, 1 mm nasal to fovea and 1 mm temporal 
      to fovea. The reflectivity ratios of outer retinal layers divided by the outer 
      nuclear layer (ONL) were calculated for normalization. Photoreceptor outer 
      segment layer thickness was also measured. The results were compared between the 
      patients and controls. RESULTS: The reflectivity ratio of ellipsoid zone/ONL and 
      outer segment/ONL was higher in commotio retinae than in controls only at fovea 
      (12.66 +/- 4.73 vs 9.67 +/- 3.34, p = 0.041; 7.70 +/- 2.20 vs 3.73 +/- 1.63, p < 0.001, 
      respectively) but not at 1 mm nasal or temporal to the fovea. Photoreceptor outer 
      segment layer thickness was significantly shorter in commotio retinae compared to 
      controls at all three locations (19.64 +/- 3.05 vs 25.16 +/- 3.53, 16.95 +/- 4.02 vs 
      20.00 +/- 3.00, and 15.42 +/- 3.22 vs 20.05 +/- 2.48, respectively, all p < 0.05). 
      CONCLUSIONS: Quantitative measurement of SD-OCT images revealed that shortening 
      of photoreceptor outer segment is an additional, and potentially better, 
      biomarker for commotio retinae on top of increased reflectivity.
FAU - Xia, Honghe
AU  - Xia H
AD  - Joint Shantou International Eye Center, Shantou University & the Chinese 
      University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong Province, 
      China.
FAU - Ke, Xixuan
AU  - Ke X
AD  - Joint Shantou International Eye Center, Shantou University & the Chinese 
      University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong Province, 
      China.
FAU - Chen, Li Jia
AU  - Chen LJ
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, China.
FAU - Yan, Hua
AU  - Yan H
AD  - General Hospital, Tianjin Medical University, Tianjin, China.
FAU - Chen, Haoyu
AU  - Chen H
AUID- ORCID: 0000-0003-0676-4610
AD  - Joint Shantou International Eye Center, Shantou University & the Chinese 
      University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong Province, 
      China. drchenhaoyu@gmail.com.
LA  - eng
GR  - 002-18119101/Grant for Key Disciplinary Project of Clinical Medicine under the 
      Guangdong High-level University Development Program/
GR  - 170829231930502/Shantou Science and Technology Program/
GR  - 2012-18/Research Grant of Joint Shantou International Eye Center/
PT  - Journal Article
DEP - 20200420
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Eye Injuries/*diagnosis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/diagnostic imaging/*injuries
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
MH  - Wounds, Nonpenetrating/*diagnosis
MH  - Young Adult
OTO - NOTNLM
OT  - Commotio retinae
OT  - Optical coherence tomography
OT  - Photoreceptor outer segment
OT  - Reflectivity
EDAT- 2020/04/22 06:00
MHDA- 2021/04/14 06:00
CRDT- 2020/04/22 06:00
PHST- 2020/01/08 00:00 [received]
PHST- 2020/04/01 00:00 [accepted]
PHST- 2020/02/28 00:00 [revised]
PHST- 2020/04/22 06:00 [pubmed]
PHST- 2021/04/14 06:00 [medline]
PHST- 2020/04/22 06:00 [entrez]
AID - 10.1007/s00417-020-04678-9 [pii]
AID - 10.1007/s00417-020-04678-9 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2020 Jul;258(7):1437-1442. doi: 
      10.1007/s00417-020-04678-9. Epub 2020 Apr 20.