PMID- 32314124 OWN - NLM STAT- MEDLINE DCOM- 20201013 LR - 20201013 IS - 1869-4098 (Electronic) IS - 1869-408X (Linking) VI - 11 IP - 3 DP - 2020 Jun TI - Non-Invasive Quantification of Ventricular Contractility, Arterial Elastic Function and Ventriculo-Arterial Coupling from a Single Diagnostic Encounter Using Simultaneous Arterial Tonometry and Magnetic Resonance Imaging. PG - 283-294 LID - 10.1007/s13239-020-00462-2 [doi] AB - PURPOSE: Optimal assessment of cardiovascular performance requires simultaneous measurement of load independent left ventricular (LV) contractility, arterial function and LV/arterial coupling. We aimed to demonstrate feasibility of non-invasive ventricular pressure-volume and aortic pressure-flow-impedance measurements using simultaneous arterial tonometry (AT) and cardiovascular magnetic resonance imaging (CMRI). METHODS: 21 consecutive patients referred for CMRI were enrolled to undergo a simultaneous AT and CMRI protocol. A CMRI compatible AT apparatus provided aortic end-systolic pressure, taken to be equivalent to LV end-systolic pressure in the absence of aortic stenosis. CMRI provided LV volume and aortic flow at the time of pressure acquisition. Pressure-volume relationships were determined and correlated to traditional parameters of LV function including ejection fraction and circumferential strain. Aortic pressure-flow relationships were used to determine aortic characteristic impedance and systemic vascular resistance. RESULTS: Simultaneous AT and CMRI permitted measurement of LV end-systolic elastance, preload recruitable stroke work, arterial elastance, aortic characteristic impedance and systemic vascular resistance. Absolute values were within the expected range for our cohort, were highly reproducible and showed appropriately directed correlation to traditional parameters. CONCLUSION: Non-invasive assessment of LV pressure-volume and aortic pressure-flow relationships are both feasible and reproducible using simultaneous AT and CMRI. Methods permit assessment of load independent LV contractility, arterial function and LV/arterial coupling from a single non-invasive diagnostic encounter. FAU - Namasivayam, Mayooran AU - Namasivayam M AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. mayooran.namasivayam@unsw.edu.au. AD - Faculty of Medicine, University of New South Wales, Sydney, Australia. mayooran.namasivayam@unsw.edu.au. AD - Victor Chang Cardiac Research Institute, Sydney, Australia. mayooran.namasivayam@unsw.edu.au. AD - Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. mayooran.namasivayam@unsw.edu.au. FAU - Adji, Audrey AU - Adji A AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. AD - Victor Chang Cardiac Research Institute, Sydney, Australia. AD - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia. FAU - Lin, Linda AU - Lin L AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. FAU - Hayward, Christopher S AU - Hayward CS AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. AD - Faculty of Medicine, University of New South Wales, Sydney, Australia. AD - Victor Chang Cardiac Research Institute, Sydney, Australia. FAU - Feneley, Michael P AU - Feneley MP AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. AD - Faculty of Medicine, University of New South Wales, Sydney, Australia. AD - Victor Chang Cardiac Research Institute, Sydney, Australia. FAU - O'Rourke, Michael F AU - O'Rourke MF AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. AD - Faculty of Medicine, University of New South Wales, Sydney, Australia. AD - Victor Chang Cardiac Research Institute, Sydney, Australia. FAU - Muller, David W M AU - Muller DWM AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. AD - Faculty of Medicine, University of New South Wales, Sydney, Australia. AD - Victor Chang Cardiac Research Institute, Sydney, Australia. FAU - Jabbour, Andrew AU - Jabbour A AD - Department of Cardiology, St. Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. AD - Faculty of Medicine, University of New South Wales, Sydney, Australia. AD - Victor Chang Cardiac Research Institute, Sydney, Australia. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20200420 PL - United States TA - Cardiovasc Eng Technol JT - Cardiovascular engineering and technology JID - 101531846 SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - Aged MH - Aorta/*diagnostic imaging/physiopathology MH - Brachial Artery/*diagnostic imaging/physiopathology MH - Cardiovascular Diseases/*diagnostic imaging/physiopathology MH - Elasticity MH - Feasibility Studies MH - Female MH - *Hemodynamics MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - *Manometry MH - Middle Aged MH - *Myocardial Contraction MH - Predictive Value of Tests MH - Reproducibility of Results MH - *Vascular Stiffness MH - *Ventricular Function, Left MH - Young Adult OTO - NOTNLM OT - Arterial function OT - Contractility OT - Non-invasive OT - Ventricular function OT - Ventriculo-arterial coupling EDAT- 2020/04/22 06:00 MHDA- 2020/10/21 06:00 CRDT- 2020/04/22 06:00 PHST- 2019/01/01 00:00 [received] PHST- 2020/04/07 00:00 [accepted] PHST- 2020/04/22 06:00 [pubmed] PHST- 2020/10/21 06:00 [medline] PHST- 2020/04/22 06:00 [entrez] AID - 10.1007/s13239-020-00462-2 [pii] AID - 10.1007/s13239-020-00462-2 [doi] PST - ppublish SO - Cardiovasc Eng Technol. 2020 Jun;11(3):283-294. doi: 10.1007/s13239-020-00462-2. Epub 2020 Apr 20.