PMID- 32314290
OWN - NLM
STAT- MEDLINE
DCOM- 20200710
LR  - 20220531
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 27
IP  - 18
DP  - 2020 Jun
TI  - The effect of Zataria multiflora on inflammatory cytokine and respiratory 
      symptoms in veterans exposed to sulfur mustard.
PG  - 22451-22460
LID - 10.1007/s11356-020-08855-5 [doi]
AB  - The effect of Zataria multiflora (Z. multiflora) on serum cytokine, chemokines, 
      and respiratory symptoms in the veterans exposed to sulfur mustard (SM) more than 
      two decades (27-30 years) ago was conducted in 2018. Thirty-four patients were 
      randomly assigned to the placebo group (P, mean age (54.40 +/- 5.51)) and two 
      treated groups with Z. multiflora extract 5 and 10 mg/kg/day (Z5 and 10; mean 
      age, 58.50 +/- 3.60 and 55.18 +/- 4.11, respectively). Serum levels of tumor necrosis 
      factor (TNF-alpha), monocyte chemotactic protein 1 (MCP-1), vascular endothelial 
      growth factor (VEGF), epidermal growth factor (EGF), forced expiratory volume-one 
      second (FEV(1)), and respiratory symptoms including chest wheeze (CW), night 
      wheeze (NW), night cough (NC), and cough and wheeze during exercise (ECW) were 
      assessed at the baseline (phase 0), 1 and 2 months after starting treatment 
      (phase I and II, respectively). The value of FEV(1) was significantly increased 
      in Z10 in phase I and II compared with that in phase 0 (p < 0.01 for both) and in 
      Z5 in phase II compared with phase I and 0 (p < 0.001for both). All respiratory 
      symptoms significantly decreased in Z5 and 10 in phase I and II compared with 
      those in phase 0 (p < 0.05 to p < 0.001). Serum levels of TNF-alpha and VEGF were 
      decreased in Z5 and 10 in phase I and II compared with those in phase 0 (p < 0.05 
      to p < 0.001). Serum levels of MCP-1 and EGF were decreased in Z10 in phase I and 
      II compared with those in phase 0 (p < 0.05 to p < 0.001). The percent change of 
      respiratory symptoms, serum levels of cytokines during the treatment period, was 
      significantly improved in the treated groups compared with that in the placebo 
      group. Two months' of treatment with Z. multiflora improved cytokine levels, 
      respiratory symptom, and FEV(1) values in SM-exposed patients.
FAU - Khazdair, Mohammad Reza
AU  - Khazdair MR
AD  - Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, 
      Birjand, Iran.
AD  - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Rezaeetalab, Fariba
AU  - Rezaeetalab F
AD  - COPD Research Center, Department of Internal Medicine, Imam-Reza Hospital, School 
      of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Rafatpanah, Houshang
AU  - Rafatpanah H
AD  - Department of Immunology, Immunology Research Center, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Boskabady, Mohammad Hossein
AU  - Boskabady MH
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, 9177948564, Iran. boskabadymh@mums.ac.ir.
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, 9177948564, Iran. boskabadymh@mums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200420
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - T8KEC9FH9P (Mustard Gas)
SB  - IM
MH  - *Cytokines
MH  - Humans
MH  - *Lung/drug effects/physiopathology
MH  - Middle Aged
MH  - *Mustard Gas
MH  - Plant Extracts
MH  - Respiratory Function Tests
MH  - Vascular Endothelial Growth Factor A
MH  - *Veterans
OTO - NOTNLM
OT  - Chemokine
OT  - Respiratory symptoms
OT  - Serum cytokines
OT  - Sulfur mustard
OT  - Zataria multiflora
EDAT- 2020/04/22 06:00
MHDA- 2020/07/11 06:00
CRDT- 2020/04/22 06:00
PHST- 2018/07/10 00:00 [received]
PHST- 2020/04/13 00:00 [accepted]
PHST- 2020/04/22 06:00 [pubmed]
PHST- 2020/07/11 06:00 [medline]
PHST- 2020/04/22 06:00 [entrez]
AID - 10.1007/s11356-020-08855-5 [pii]
AID - 10.1007/s11356-020-08855-5 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2020 Jun;27(18):22451-22460. doi: 
      10.1007/s11356-020-08855-5. Epub 2020 Apr 20.