PMID- 32315546
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 98
IP  - 9
DP  - 2020 Sep
TI  - The ratio of circulating endothelin-1 to endothelin-3 associated with TIMI risk 
      and dynamic TIMI risk score in ST elevation acute myocardial infarction.
PG  - 637-643
LID - 10.1139/cjpp-2019-0654 [doi]
AB  - In ST segment elevation acute myocardial infarction (STEMI), the endothelin (ET) 
      system imbalance, reflected by the circulating ET-1:ET-3 ratio has not been 
      investigated. This study's primary objective was to measure the circulating 
      ET-1:ET-3 ratio and correlate it with the risk stratification for 1 year 
      mortality of STEMI based on TIMI score. On admission, the TIMI risk score and at 
      discharge, the dynamic TIMI risk score were calculated in 68 consecutive subjects 
      with STEMI. Subjects with high TIMI risk score were associated with higher mean 
      ET-1 level and ET-1:ET-3 ratio. The ET-1:ET-3 ratio more accurately predicted the 
      high on admission TIMI risk score than the ET-1 level. Subjects with high dynamic 
      TIMI risk score were associated with higher mean ET-1 level and ET-1:ET-3 ratio. 
      The ET-1:ET-3 ratio more accurately predicted the high at discharge dynamic TIMI 
      risk score than ET-1 level. From multivariable analysis, the ET-1:ET-3 ratio was 
      not independently associated with high on admission TIMI risk score but 
      independently predicted high at discharge dynamic TIMI risk score (odds ratio = 
      9.186, p = 0.018). In conclusion, combining the ET-1 and ET-3 levels into the 
      ET-1:ET-3 ratio provided a prognostic value by independently predicting the 
      increased risk to 1 year mortality as indicated by at discharge dynamic TIMI risk 
      score in patients with STEMI.
FAU - Hartopo, Anggoro Budi
AU  - Hartopo AB
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public 
      Health and Nursing, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, 
      Indonesia.
FAU - Puspitawati, Ira
AU  - Puspitawati I
AD  - Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, 
      Public Health and Nursing, Universitas Gadjah Mada - Dr. Sardjito Hospital, 
      Yogyakarta, Indonesia.
FAU - Mumpuni, Hasanah
AU  - Mumpuni H
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public 
      Health and Nursing, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, 
      Indonesia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200421
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Cardiotonic Agents)
RN  - 0 (EDN3 protein, human)
RN  - 0 (Endothelin-1)
RN  - 0 (Endothelin-3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiotonic Agents/therapeutic use
MH  - Electric Countershock/statistics & numerical data
MH  - Electrocardiography
MH  - Endothelin-1/*blood
MH  - Endothelin-3/*blood
MH  - Female
MH  - Heart Failure/diagnosis/*epidemiology/etiology/therapy
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Admission
MH  - Patient Discharge
MH  - Percutaneous Coronary Intervention
MH  - Prognosis
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/blood/*complications/mortality/surgery
MH  - Shock, Cardiogenic/diagnosis/*epidemiology/etiology/therapy
MH  - Treatment Outcome
MH  - Ventricular Fibrillation/*epidemiology/etiology/therapy
OTO - NOTNLM
OT  - STEMI
OT  - endothelin-1
OT  - endothelin-1 to endothelin-3 ratio
OT  - endothelin-3
OT  - endotheline-1
OT  - endotheline-3
OT  - ratio endotheline-1:endotheline-3
EDAT- 2020/04/22 06:00
MHDA- 2021/07/06 06:00
CRDT- 2020/04/22 06:00
PHST- 2020/04/22 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2020/04/22 06:00 [entrez]
AID - 10.1139/cjpp-2019-0654 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2020 Sep;98(9):637-643. doi: 10.1139/cjpp-2019-0654. 
      Epub 2020 Apr 21.