PMID- 32316314
OWN - NLM
STAT- MEDLINE
DCOM- 20210128
LR  - 20221207
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 4
DP  - 2020 Apr 16
TI  - A Study on the Relationship between Type 2 Diabetes and Taste Function in 
      Patients with Good Glycemic Control.
LID - 10.3390/nu12041112 [doi]
LID - 1112
AB  - Type 2 diabetes mellitus (T2DM) has a very high impact on quality of life as it 
      is characterized by disabling complications. There is little evidence about taste 
      alterations in diabetes. Since many individual factors are involved in the onset 
      of diabetes, the purpose of our study is to search a possible link between 
      diabetes and individual taste function. Thirty-two participants with T2DM and 32 
      volunteers without T2DM (healthy controls) were recruited. Four concentrations of 
      each of the four basic tastes (sweet, sour, salty, bitter), and pure rapeseed oil 
      and water, were applied with cotton pads to the protruded tongue, immediately 
      posterior to its first third, either to the left or right side. The results 
      showed significant differences between groups in the ability to recognize sour, 
      bitter, sweet, and water. Taste scores were lower in subjects with T2DM than in 
      healthy controls, and an age-related decline in taste function was found. The 
      taste function reduction associated with T2DM was not related to gender, disease 
      duration, and glycemic control. In conclusion, it can be hypothesized that a 
      general alteration of taste function can lead patients with type 2 diabetes to 
      search for foods richer in sugars, as in a vicious circle, thus decreasing the 
      likelihood of remission of diabetes mellitus.
FAU - Pugnaloni, Sofia
AU  - Pugnaloni S
AUID- ORCID: 0000-0003-1499-8943
AD  - Department of Clinical Sciences, Section of Biochemistry, Biology and Physics, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Alia, Sonila
AU  - Alia S
AD  - Department of Clinical Sciences, Section of Biochemistry, Biology and Physics, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Mancini, Margherita
AU  - Mancini M
AD  - Department of Clinical Sciences, School of Specialization in Clinical Nutrition, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Santoro, Vito
AU  - Santoro V
AD  - Department of Clinical Sciences, School of Specialization in Clinical Nutrition, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Di Paolo, Alice
AU  - Di Paolo A
AD  - Department of Clinical Sciences, Section of Biochemistry, Biology and Physics, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Rabini, Rosa Anna
AU  - Rabini RA
AD  - Diabetology Department, IRCCS INRCA, Via della Montagnola 81, 60127 Ancona, 
      Italy.
FAU - Fiorini, Rosamaria
AU  - Fiorini R
AD  - Department of Life and Environmental Sciences, Universita Politecnica delle 
      Marche, Via Brecce Bianche, 60131 Ancona, Italy.
FAU - Sabbatinelli, Jacopo
AU  - Sabbatinelli J
AUID- ORCID: 0000-0001-9947-6778
AD  - Department of Clinical Sciences, Section of Biochemistry, Biology and Physics, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Fabri, Mara
AU  - Fabri M
AD  - Department of Experimental and Clinical Medicine, Universita Politecnica delle 
      Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Mazzanti, Laura
AU  - Mazzanti L
AD  - Department of Clinical Sciences, Section of Biochemistry, Biology and Physics, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
FAU - Vignini, Arianna
AU  - Vignini A
AD  - Department of Clinical Sciences, Section of Biochemistry, Biology and Physics, 
      Universita Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200416
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/physiology
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology/therapy
MH  - Diet, Diabetic
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - *Taste
MH  - Young Adult
PMC - PMC7230282
OTO - NOTNLM
OT  - diabetes
OT  - food preferences
OT  - gender
OT  - taste function
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/23 06:00
MHDA- 2021/01/29 06:00
PMCR- 2020/04/01
CRDT- 2020/04/23 06:00
PHST- 2020/02/28 00:00 [received]
PHST- 2020/04/11 00:00 [revised]
PHST- 2020/04/13 00:00 [accepted]
PHST- 2020/04/23 06:00 [entrez]
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2021/01/29 06:00 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - nu12041112 [pii]
AID - nutrients-12-01112 [pii]
AID - 10.3390/nu12041112 [doi]
PST - epublish
SO  - Nutrients. 2020 Apr 16;12(4):1112. doi: 10.3390/nu12041112.