PMID- 32316442
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 10
IP  - 4
DP  - 2020 Apr 17
TI  - Immunomodulation of Avian Dendritic Cells under the Induction of Prebiotics.
LID - 10.3390/ani10040698 [doi]
LID - 698
AB  - Although the immunomodulatory properties of prebiotics were demonstrated many 
      years ago in poultry, not all mechanisms of action are yet clear. Dendritic cells 
      (DCs) are the main antigen-presenting cells orchestrating the immune response in 
      the chicken gastrointestinal tract, and they are the first line of defense in the 
      immune response. Despite the crucial role of DCs in prebiotic immunomodulatory 
      properties, information is lacking about interaction between prebiotics and DCs 
      in an avian model. Mannan-oligosaccharides, beta-glucans, fructooligosaccharides, 
      and chitosan-oligosaccharides are the main groups of prebiotics having 
      immunomodulatory properties. Because pathogen-associated molecular patterns on 
      these prebiotics are recognized by many receptors of DCs, prebiotics can mimic 
      activation of DCs by pathogens. Short-chain fatty acids are products of prebiotic 
      fermentation by microbiota, and their anti-inflammatory properties have also been 
      demonstrated in DCs. This review summarizes current knowledge about avian DCs in 
      the gastrointestinal tract, and for the first-time, their role in the 
      immunomodulatory properties of prebiotics within an avian model.
FAU - Zmrhal, Vladimir
AU  - Zmrhal V
AUID- ORCID: 0000-0003-4534-685X
AD  - Department of Animal Morphology, Physiology and Genetics, Faculty of 
      AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech 
      Republic.
FAU - Slama, Petr
AU  - Slama P
AUID- ORCID: 0000-0003-0570-259X
AD  - Department of Animal Morphology, Physiology and Genetics, Faculty of 
      AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech 
      Republic.
LA  - eng
GR  - AF-IGA2020-IP040/Mendelova Univerzita v Brne/
PT  - Journal Article
PT  - Review
DEP - 20200417
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC7222706
OTO - NOTNLM
OT  - antigen-presenting cell
OT  - avian dendritic cells
OT  - chicken
OT  - pattern recognition receptors
OT  - prebiotic
COIS- The authors declare no conflicts of interest.
EDAT- 2020/04/23 06:00
MHDA- 2020/04/23 06:01
PMCR- 2020/04/17
CRDT- 2020/04/23 06:00
PHST- 2020/02/19 00:00 [received]
PHST- 2020/04/09 00:00 [revised]
PHST- 2020/04/15 00:00 [accepted]
PHST- 2020/04/23 06:00 [entrez]
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2020/04/23 06:01 [medline]
PHST- 2020/04/17 00:00 [pmc-release]
AID - ani10040698 [pii]
AID - animals-10-00698 [pii]
AID - 10.3390/ani10040698 [doi]
PST - epublish
SO  - Animals (Basel). 2020 Apr 17;10(4):698. doi: 10.3390/ani10040698.