PMID- 32316726
OWN - NLM
STAT- MEDLINE
DCOM- 20210101
LR  - 20210101
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 68
IP  - 19
DP  - 2020 May 13
TI  - 3'-Hydroxypterostilbene Potently Alleviates Obesity Exacerbated Colitis in Mice.
PG  - 5365-5374
LID - 10.1021/acs.jafc.0c01782 [doi]
AB  - Epidemiological surveys show that obesity and the western diet increase the risk 
      of colitis. Studies have also confirmed that the high-fat-diet (HFD) promoted the 
      deterioration of colitis-related indicators in mice. Compared with stilbenoids, 
      the results showed that 3'-hydroxypterostilbene (HPSB) was found to be the most 
      effective inhibitor for the antiadipogenesis and anti-inflammation. However, its 
      role in ameliorating obesity-promoted colitis is still unknown. We intend to 
      investigate the protective effect and related molecular mechanisms of HPSB on HFD 
      promoted dextran sodium sulfate (DSS)-induced colitis in mice. The results 
      indicate that colitis in the HFD+DSS group tends to be more apparent in the 
      DSS-only group, while feeding 0.025% of HPSB at different stages can improve the 
      colitis induced by HFD+DSS. HPSB significantly reduced the levels of 
      interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) induced by 
      HFD+DSS in mice. Furthermore, the Western blotting revealed that the 
      administration of HPSB significantly downregulated cyclooxygenase-2 (COX-2), 
      plasmalemma vesicle-associated protein-1 (PV-1), and phospho-signal transducer 
      and activator of transcription 3 (p-STAT3) expressions in HFD+DSS treated mice. 
      Presented results reveal that HPSB is a novel functional agent capable of 
      preventing HFD exacerbated colitis.
FAU - Lee, Pei-Sheng
AU  - Lee PS
AD  - Institute of Food Science and Technology, National Taiwan University, Taipei 
      10617, Taiwan.
FAU - Chiou, Yi-Shiou
AU  - Chiou YS
AD  - Institute of Food Science and Technology, National Taiwan University, Taipei 
      10617, Taiwan.
AD  - Tsinghua Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, 
      China.
FAU - Nagabhushanam, Kalyanam
AU  - Nagabhushanam K
AUID- ORCID: 0000-0001-9470-4110
AD  - Sabinsa Corporation, East Windsor, New Jersey 08520, United States.
FAU - Ho, Chi-Tang
AU  - Ho CT
AD  - Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, 
      United States.
FAU - Pan, Min-Hsiung
AU  - Pan MH
AUID- ORCID: 0000-0002-5188-7030
AD  - Institute of Food Science and Technology, National Taiwan University, Taipei 
      10617, Taiwan.
AD  - Department of Medical Research, China Medical University Hospital, China Medical 
      University, Taichung 40402, Taiwan.
AD  - Department of Health and Nutrition Biotechnology, Asia University, Taichung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20200430
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (3'-hydroxypterostilbene)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stilbenes)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/administration & dosage
MH  - Chemokine CCL2/genetics/immunology
MH  - Colitis/chemically induced/*drug therapy/genetics/immunology
MH  - Dextran Sulfate/adverse effects
MH  - Diet, High-Fat/adverse effects
MH  - Disease Models, Animal
MH  - Humans
MH  - Interleukin-6/genetics/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*complications/etiology/genetics/immunology
MH  - STAT3 Transcription Factor/genetics/immunology
MH  - Stilbenes/*administration & dosage
OTO - NOTNLM
OT  - 3'-hydroxypterostilbene (HPSB)
OT  - chemoprevention
OT  - colitis
OT  - obesity
EDAT- 2020/04/23 06:00
MHDA- 2021/01/02 06:00
CRDT- 2020/04/23 06:00
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2021/01/02 06:00 [medline]
PHST- 2020/04/23 06:00 [entrez]
AID - 10.1021/acs.jafc.0c01782 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2020 May 13;68(19):5365-5374. doi: 10.1021/acs.jafc.0c01782. 
      Epub 2020 Apr 30.