PMID- 32318911
OWN - NLM
STAT- MEDLINE
DCOM- 20210322
LR  - 20230426
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 14
IP  - 6
DP  - 2020 Dec
TI  - Functional connectivity changes of nucleus Accumbens Shell portion in left mesial 
      temporal lobe epilepsy patients.
PG  - 2659-2667
LID - 10.1007/s11682-019-00217-1 [doi]
AB  - Growing evidence has supported that the nucleus accumbens (NAc), especially its 
      shell portion, has been involved in epileptogenesis. However, relevant studies on 
      vivo human brain are quite limited. In this study, we investigated left mesial 
      temporal lobe epilepsy (MTLE) related function connectivity (FC) changes of NAc 
      subregions using resting-state functional magnetic resonance imaging. We 
      calculated functional connectivity from two NAc subregions to both whole brain 
      and 16 related targets. Two-sample t-test (Alphasim multiple comparisons 
      corrected) was performed to identify the effect of the disease on each seed's 
      whole brain network. Repeated-measures ANOVA and Post hoc pairwise t test 
      (Bonferroni corrections) were performed to visualize the seed to target FC group 
      differences in each subdivision. In whole brain FC networks, neither the left or 
      right core show different FC changes. The left shell showed decreased FC with a 
      cluster located around the right inferior frontal gyrus. The right shell portion 
      showed increased FC with a cluster located around the left inferior temporal 
      gyrus. The seed to targets results showed that the left shell of LTLE group 
      exhibited lower FC with left posterior-parahippocampal gyrus and right caudate, 
      putamen, thalamus, paracingulate gyrus but higher FC with right subcallosal 
      cortex. The right core of LTLE group exhibited higher FC with right frontal pole 
      and the right shell exhibited lower FC with left thalamus and left 
      anterior-parahippocampal gyrus. This is the first study to investigate the 
      functional connectivity changes of NAc subdivisions of epilepsy in vivo human 
      brain. Our results showed that the left MTLE related FC changes on NAc are mainly 
      on shell portion rather than core. The decrease FC between the left shell and 
      right frontal area and the decrease FC between the right shell and left temporal 
      area suggested they serve vital roles for MTLE.
FAU - Yang, Ru
AU  - Yang R
AUID- ORCID: 0000-0003-0373-706X
AD  - Guangdong Provincial Key Laboratory of Medical Image Processing, School of 
      Biomedical Engineering, Southern Medical University, Guangzhou, 510,515, China.
AD  - Department of Radiology, The second Xiangya Hospital, Central South University, 
      Changsha, 410,011, China.
FAU - Zhao, Xixi
AU  - Zhao X
AD  - Department of Medical Imaging Center, Nanfang Hospital, Southern Medical 
      University, Guangzhou, 510,515, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Radiology, The second Xiangya Hospital, Central South University, 
      Changsha, 410,011, China.
FAU - Yao, Xufeng
AU  - Yao X
AD  - School of Radiology, Shanghai University of Medicine & Health Science, Shanghai, 
      201,318, China.
FAU - Hou, Feng
AU  - Hou F
AD  - Department of Radiology, The second Xiangya Hospital, Central South University, 
      Changsha, 410,011, China.
FAU - Xu, Yikai
AU  - Xu Y
AD  - Department of Medical Imaging Center, Nanfang Hospital, Southern Medical 
      University, Guangzhou, 510,515, China. yikaivip@163.com.
FAU - Feng, Qianjin
AU  - Feng Q
AD  - Guangdong Provincial Key Laboratory of Medical Image Processing, School of 
      Biomedical Engineering, Southern Medical University, Guangzhou, 510,515, China. 
      qianjinfeng08@gmail.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Brain Mapping
MH  - *Epilepsy, Temporal Lobe/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Nucleus Accumbens
MH  - Temporal Lobe
OTO - NOTNLM
OT  - Functional connectivity
OT  - Mesial temporal lobe epilepsy
OT  - Nucleus accumbens
OT  - Resting-state fMRI
EDAT- 2020/04/23 06:00
MHDA- 2021/03/23 06:00
CRDT- 2020/04/23 06:00
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2021/03/23 06:00 [medline]
PHST- 2020/04/23 06:00 [entrez]
AID - 10.1007/s11682-019-00217-1 [pii]
AID - 10.1007/s11682-019-00217-1 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2020 Dec;14(6):2659-2667. doi: 10.1007/s11682-019-00217-1.