PMID- 32319821
OWN - NLM
STAT- MEDLINE
DCOM- 20210326
LR  - 20210326
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 25
IP  - 4
DP  - 2020 Jun
TI  - Management of Citrus sinensis peels for protection and treatment against gastric 
      ulcer induced by ethanol in rats.
PG  - 349-359
LID - 10.1080/1354750X.2020.1759693 [doi]
AB  - Introduction: Stomach ulcer is one of the most prevalent disorders worldwide. The 
      study was aimed to isolate and characterize the major polymethoxylated flavonoids 
      in Citrus sinensis peels petroleum ether extract and investigate its protective 
      and curative effect on gastric ulcer.Material and methods: Some spectral analyses 
      were used for identification of the isolated compounds from the petroleum ether 
      extract of Citrus sinensis peels. One oral dose (0.5 ml/100 g b.wt.) of absolute 
      ethanol was orally given to rats after starvation for 24 h to induce gastric 
      ulcer. To explore the protective and curative role of the plant extract, it was 
      orally (250 mg/kg b.wt.) given for 1 week either before or post-ulcer induction. 
      A reference drug, ranitidine (100 mg/kg b.wt.), was also evaluated. Stomach 
      acidity, gastric volume, lesion counts, glutathione (GSH), superoxide dismutase 
      (SOD), malondialdehyde (MDA), succinate dehydrogenase (SDH), lactate 
      dehydrogenase (LDH), acid phosphatase (AP), interlukin-10 (IL-10) and 
      prostaglandin E2 (PGE2) were estimated. Stomach histopathological features were 
      monitored.Results: Nine polymethoxy flavonoids were identified from the extract. 
      Treatment with C. sinensis peels extract recorded amelioration in all 
      parameters.Conclusion: Citrus sinensis petroleum ether peels extract had 
      protective and curative effects against gastric ulcer. Therefore, the extract 
      recorded anti-secretory, anti-ulcerative, anti-inflammatory, and antioxidant 
      effects. Its healing action exceeded its protective role due to its richness in 
      polymethoxylated flavonoids.
FAU - Aboul Naser, Asmaa
AU  - Aboul Naser A
AD  - Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, 
      Egypt.
FAU - Younis, Eman
AU  - Younis E
AD  - Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, 
      Egypt.
FAU - El-Feky, Amal
AU  - El-Feky A
AD  - Department of Pharmacognosy, National Research Centre, Dokki, Giza, Egypt.
FAU - Elbatanony, Marwa
AU  - Elbatanony M
AD  - Department of Pharmacognosy, National Research Centre, Dokki, Giza, Egypt.
FAU - Hamed, Manal
AU  - Hamed M
AD  - Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20200507
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 3K9958V90M (Ethanol)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antioxidants/chemistry/*pharmacology
MH  - Catalase/genetics
MH  - Citrus sinensis/*chemistry
MH  - Ethanol/toxicity
MH  - Gastric Mucosa/drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Glutathione/genetics
MH  - Humans
MH  - Malondialdehyde/metabolism
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Rats
MH  - Stomach Ulcer/chemically induced/*drug therapy/pathology
MH  - Superoxide Dismutase/genetics
OTO - NOTNLM
OT  - Citrus sinensis
OT  - ethanol
OT  - gastric ulcer
OT  - polymethoxylated flavonoids
OT  - ranitidine
EDAT- 2020/04/23 06:00
MHDA- 2021/03/27 06:00
CRDT- 2020/04/23 06:00
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2021/03/27 06:00 [medline]
PHST- 2020/04/23 06:00 [entrez]
AID - 10.1080/1354750X.2020.1759693 [doi]
PST - ppublish
SO  - Biomarkers. 2020 Jun;25(4):349-359. doi: 10.1080/1354750X.2020.1759693. Epub 2020 
      May 7.