PMID- 32319873
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1718-4304 (Electronic)
IS  - 0896-8608 (Linking)
VI  - 41
IP  - 1
DP  - 2021 Jan
TI  - Associations between diabetes and sex with peritoneal dialysis technique and 
      patient survival: Results from the Australia and New Zealand Dialysis and 
      Transplant Registry cohort study.
PG  - 57-68
LID - 10.1177/0896860820918708 [doi]
AB  - BACKGROUND: A differential association between mortality and cause of end-stage 
      kidney disease in patients with type 2 diabetes mellitus (T2DM) has been shown. 
      Sex-specific differences in diabetes-related complications have been described. 
      It is unclear whether sex affects the associations between diabetes and 
      peritoneal dialysis (PD) technique and patient survival. METHODS: Using the 
      Australia and New Zealand Dialysis and Transplant Registry, we examined a two-way 
      interaction between sex and diabetes status (no diabetes, T2DM and non-diabetic 
      nephropathy [T2DM + non-DN] and T2DM and diabetic nephropathy [T2DM + DN]) for PD 
      technique failure (including death), all-cause mortality and cause-specific 
      mortality in incident adult PD patients between 1996 and 2016 using adjusted Cox 
      regression. Mediation analysis was conducted to determine whether peritonitis was 
      a mediator in these associations. RESULTS: In 8279 PD patients, those with 
      T2DM + DN had the greatest risks in technique failure, all-cause mortality and 
      cause-specific mortality followed by patients with T2DM + non-DN, then patients 
      without diabetes. Sex modified the association with diabetes status in technique 
      failure (p(interaction) = 0.001) and cardiac mortality (p(interaction) = 0.008). 
      In women with T2DM + DN, the adjusted hazard ratio (HR) for technique failure was 
      1.45 (1.30-1.62) and was higher than men with T2DM + DN (1.17 [1.08-1.28]; 
      referent: no diabetes). In women with T2DM + DN, the adjusted HR for cardiac 
      mortality was 2.12 (1.73-2.61) and was also higher than men with T2DM + DN (1.66 
      [1.43-1.95]). Less than 10 % of the effect between diabetes and PD technique 
      failure or mortality was mediated by peritonitis. CONCLUSIONS: PD patients with 
      diabetic nephropathy had increased risk of PD technique failure and mortality, 
      with the magnitude of these risks greater in women.
FAU - Chen, Jenny Hc
AU  - Chen JH
AUID- ORCID: 0000-0001-8900-2819
AD  - School of Medicine, University of New South Wales, Sydney, Australia.
AD  - Department of Renal Medicine, 60122Wollongong Hospital, New South Wales, 
      Australia.
AD  - The George Institute for Global Health, Sydney, New South Wales, Australia.
FAU - Johnson, David W
AU  - Johnson DW
AD  - Department of Nephrology, 1966Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
AD  - Centre for Health Services Research, University of Queensland, Brisbane, 
      Australia.
AD  - Translational Research Institute, Brisbane, Queensland, Australia.
AD  - Australasian Kidney Trials Network, Brisbane, Queensland, Australia.
FAU - Wong, Germaine
AU  - Wong G
AD  - Sydney School of Public Health, University of Sydney, Camperdown, New South 
      Wales, Australia.
AD  - Centre for Kidney Research, The Children's Hospital at Westmead, New South Wales, 
      Australia.
AD  - Centre for Transplant and Renal Research, Westmead Hospital, New South Wales, 
      Australia.
FAU - Boudville, Neil
AU  - Boudville N
AD  - Department of Renal Medicine, 5728Sir Charles Gairdner Hospital, Perth, Western 
      Australia, Australia.
AD  - Medical School, 2720University of Western Australia, Perth, Australia.
FAU - Borlace, Monique
AU  - Borlace M
AD  - Central Northern Adelaide Renal and Transplantation Service, 1062Royal Adelaide 
      Hospital, South Australia, Australia.
FAU - Walker, Rachael
AU  - Walker R
AD  - Sydney School of Public Health, University of Sydney, Camperdown, New South 
      Wales, Australia.
AD  - 63590Eastern Institute of Technology, Napier, New Zealand.
FAU - Hawley, Carmel
AU  - Hawley C
AD  - Department of Nephrology, 1966Princess Alexandra Hospital, Brisbane, Queensland, 
      Australia.
AD  - Centre for Health Services Research, University of Queensland, Brisbane, 
      Australia.
AD  - Translational Research Institute, Brisbane, Queensland, Australia.
AD  - Australasian Kidney Trials Network, Brisbane, Queensland, Australia.
FAU - McDonald, Stephen
AU  - McDonald S
AD  - Central and Northern Adelaide Renal and Transplantation Services, South 
      Australia, Australia.
AD  - Adelaide Medical School, The University of Adelaide, South Australia, Australia.
AD  - Australia and New Zealand Dialysis and Transplant Registry, SA Health and Medical 
      Research Institute, Adelaide, South Australia, Australia.
FAU - Lim, Wai H
AU  - Lim WH
AD  - Department of Renal Medicine, 5728Sir Charles Gairdner Hospital, Perth, Western 
      Australia, Australia.
AD  - Medical School, 2720University of Western Australia, Perth, Australia.
LA  - eng
PT  - Journal Article
DEP - 20200422
PL  - United States
TA  - Perit Dial Int
JT  - Peritoneal dialysis international : journal of the International Society for 
      Peritoneal Dialysis
JID - 8904033
SB  - IM
MH  - Australia/epidemiology
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - *Kidney Failure, Chronic/diagnosis/therapy
MH  - Male
MH  - New Zealand/epidemiology
MH  - *Peritoneal Dialysis/adverse effects
MH  - Registries
MH  - Renal Dialysis
OTO - NOTNLM
OT  - Diabetes
OT  - end-stage kidney disease
OT  - mortality
OT  - peritoneal dialysis
OT  - sex
OT  - technique failure
EDAT- 2020/04/23 06:00
MHDA- 2021/11/25 06:00
CRDT- 2020/04/23 06:00
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2020/04/23 06:00 [entrez]
AID - 10.1177/0896860820918708 [doi]
PST - ppublish
SO  - Perit Dial Int. 2021 Jan;41(1):57-68. doi: 10.1177/0896860820918708. Epub 2020 
      Apr 22.