PMID- 32320728
OWN - NLM
STAT- MEDLINE
DCOM- 20210218
LR  - 20220728
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 257
DP  - 2020 Jul 15
TI  - Is gastrointestinal motility related to alkaloids of Charred Semen Arecae?
PG  - 112825
LID - S0378-8741(20)30019-2 [pii]
LID - 10.1016/j.jep.2020.112825 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Semen Arecae (SA) is one of the most commonly 
      used Traditional Chinese Medicine. Charred Semen Arecae (CSA) is the processed 
      product of SA. Alkaloids are considered as pharmacological mechanisms of SA and 
      CSA on gastrointestinal motility. Recent studies have shown alkaloids decreased 
      quickly after procession. However, the promoting on gastrointestinal motility 
      were not decreased. Is gastrointestinal motility related to alkaloids of CSA? 
      This study explored the effects of SA, CSA, Semen Arecae-Removal (SA-R), and 
      Charred Semen Arecae-Removal (CSA-R) on gastrointestinal motility, Gastric 
      Inhibitory Polypeptide (GIP), Glucagon Like Peptide-1 (GLP-1), gastric juice and 
      bile in rats. MATERIAL AND METHODS: Rats were randomly divided into six groups, 
      including the Control group, SA group, CSA group, SA-R group, CSA-R group, and 
      Positive drug group (Mosapride). Alkaloids of samples were knocked out by using 
      the "target constituent removal" strategy. Gastric residue and intestinal 
      propulsion rate were evaluated in rats. Serum levels of GIP and GLP-1 were 
      measured by Enzyme-Linked Immunosorbent Assay (ELISA). Gastric juice and bile 
      were examined, respectively. RESULTS: CSA-R and SA-R have been investigated by 
      the Preparative Thin-layer Chromatography (PTLC) method. Intestinal propulsion 
      and gastric residue assessments confirmed the effectiveness of CSA and CSA-R. 
      CSA-R was higher than SA-R in the GLP-1, pepsin activity, the secretion of bile, 
      Bilirubin (BIL), and Cholesterol (CHO). The statistical comparison demonstrated 
      that there is no difference between the CSA group and CSA-R group. CONCLUSIONS: 
      After processing, the promoting gastrointestinal motility might be not related to 
      alkaloids. Maillard reaction could be produced to promote the secretion of GLP-1, 
      bile, and CHO for gastrointestinal motility. Our findings provide a 
      pharmacological reference for the clinical application of SA and CSA in the 
      treatment of digestive diseases.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Zhang, Feng
AU  - Zhang F
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, 610072, China.
FAU - Yang, Peng
AU  - Yang P
AD  - Chengdu Fifth People's Hospital, Chengdu, 611137, China.
FAU - He, Qiujun
AU  - He Q
AD  - Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of 
      Traditional Chinese Medicine, Chengdu, 611137, China.
FAU - Dong, Xing
AU  - Dong X
AD  - Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of 
      Traditional Chinese Medicine, Chengdu, 611137, China.
FAU - Zhang, Sanyin
AU  - Zhang S
AD  - Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of 
      Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address: 
      tcmzsy@cdutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200419
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Alkaloids)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 59392-49-3 (Gastric Inhibitory Polypeptide)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Alkaloids/*pharmacology
MH  - Animals
MH  - *Areca
MH  - Bile/drug effects
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Gastric Inhibitory Polypeptide/analysis/blood/metabolism
MH  - Gastric Juice/drug effects
MH  - Gastrointestinal Motility/*drug effects
MH  - Glucagon-Like Peptide 1/blood/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Bile
OT  - Charred semen arecae
OT  - GIP
OT  - GLP-1
OT  - Gastrointestinal motility
COIS- Declaration of competing interest The authors declare that they have no conflicts 
      of interest.
EDAT- 2020/04/23 06:00
MHDA- 2021/02/20 06:00
CRDT- 2020/04/23 06:00
PHST- 2020/01/02 00:00 [received]
PHST- 2020/03/17 00:00 [revised]
PHST- 2020/03/30 00:00 [accepted]
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/04/23 06:00 [entrez]
AID - S0378-8741(20)30019-2 [pii]
AID - 10.1016/j.jep.2020.112825 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2020 Jul 15;257:112825. doi: 10.1016/j.jep.2020.112825. Epub 
      2020 Apr 19.