PMID- 32320840
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 77
DP  - 2020 May
TI  - Identifying gene-environment interactions on the efficacy of folic acid therapy 
      for hyperhomocysteinemia based on prediction model.
PG  - 54-61
LID - S0271-5317(19)31179-0 [pii]
LID - 10.1016/j.nutres.2020.03.001 [doi]
AB  - Various genetic and environmental factors or their interactions may result in the 
      failure of folic acid therapy for hyperhomocysteinemia (HHcy). We hypothesized 
      that an optimal predictive model of gene-environment interactions could be 
      constructed to predict the efficacy of folic acid therapy in HHcy. A prospective 
      cohort study of 638 HHcy patients was performed. The patients were treated with 
      oral folic acid (5 mg/d) for 90 days. We used conditional inference tree model to 
      stratify the failure risk of folic acid therapy synthesizing information from a 
      weighted genetic risk score (wGRS) and environmental exposures, simultaneously 
      interpreting the gene-environment interaction network in predicting the efficacy 
      of HHcy. We detected high-order interactions between medical history of stroke, 
      coronary heart disease (CHD), wGRS, and baseline total homocysteine (tHcy) on the 
      failure risk of folic acid therapy. The wGRS in fourth quartile had 3.73-fold 
      increased failure risk of folic acid treatment (odds ratio = 3.73, 95% confidence 
      interval: 1.47-9.45). Stroke was identified as the key discriminator among the 
      variables examined. A total of 3.3% of participants in failure group were at the 
      lowest failure risk of folic acid therapy (nonstroke, non-CHD, baseline tHcy </= 
      31.1 mumol/L, wGRS </= 1.05). Individuals with stroke but with wGRS > 1.05 were at 
      the highest failure risk of folic acid therapy (91.0% of participants in failure 
      group). Medical history of stroke, CHD, wGRS, and baseline tHcy were consistently 
      identified as significant risk factors for the failure risk of folic acid 
      therapy. The multiple interactions between genetic and environmental factors can 
      be visually presented via the conditional inference tree model.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Zhao, Qinglin
AU  - Zhao Q
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou 450001,Henan, People's Republic of China.
FAU - Li, Dankang
AU  - Li D
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou 450001,Henan, People's Republic of China.
FAU - Huang, Xiaowen
AU  - Huang X
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou 450001,Henan, People's Republic of China.
FAU - Ren, Bingnan
AU  - Ren B
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou 450001,Henan, People's Republic of China.
FAU - Yue, Limin
AU  - Yue L
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou 450001,Henan, People's Republic of China.
FAU - Du, Binghui
AU  - Du B
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou 450001,Henan, People's Republic of China.
FAU - Zhang, Chengda
AU  - Zhang C
AD  - Department of International Medicine, Beaumont Health System, Royal Oak, MI, 
      48073, United States.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - Department of Epidemiology, School of Public Health, Zhengzhou University, 
      Zhengzhou 450001,Henan, People's Republic of China. Electronic address: 
      imooni@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200310
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Aged
MH  - Algorithms
MH  - Coronary Disease/complications
MH  - Female
MH  - Folic Acid/*therapeutic use
MH  - *Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*drug therapy/genetics
MH  - Logistic Models
MH  - Machine Learning
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stroke/complications
MH  - Treatment Failure
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Conditional inference tree
OT  - Folic acid
OT  - Gene
OT  - Hyperhomocysteinemia
OT  - Interaction
EDAT- 2020/04/23 06:00
MHDA- 2021/05/26 06:00
CRDT- 2020/04/23 06:00
PHST- 2019/12/01 00:00 [received]
PHST- 2020/02/24 00:00 [revised]
PHST- 2020/03/06 00:00 [accepted]
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/04/23 06:00 [entrez]
AID - S0271-5317(19)31179-0 [pii]
AID - 10.1016/j.nutres.2020.03.001 [doi]
PST - ppublish
SO  - Nutr Res. 2020 May;77:54-61. doi: 10.1016/j.nutres.2020.03.001. Epub 2020 Mar 10.