PMID- 32320982
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200708
IS  - 1421-9794 (Electronic)
IS  - 0009-3157 (Linking)
VI  - 64
IP  - 5-6
DP  - 2019
TI  - Stereotactic Body Radiotherapy Combined with Transcatheter Arterial 
      Chemoembolization versus Stereotactic Body Radiotherapy Alone as the First-Line 
      Treatment for Unresectable Hepatocellular Carcinoma: A Meta-Analysis and 
      Systematic Review.
PG  - 248-258
LID - 10.1159/000505739 [doi]
AB  - BACKGROUND: The superiority of stereotactic body radiotherapy (SBRT) combined 
      with transcatheter arterial chemoembolization (TACE) compared to SBRT alone as 
      the first-line therapy for unresectable hepatocellular carcinoma (HCC) remains 
      unclear. We conducted this meta-analysis to compare the efficiency and safety of 
      SBRT combined with TACE (ST group) and SBRT alone (SA group). METHODS: We 
      searched PubMed, Ovid Medline, Web of Science, Scopus, The Cochrane Library, 
      ScienceDirect, EMBASE, Google Scholar, and CNKI (China National Knowledge 
      Infrastructure) for related studies. We analyzed overall survival (OS), local 
      control survival (LCS), progression-free survival (PFS), the response rate and 
      adverse effects (AEs) between the 2 groups. RESULTS: Ten articles were included, 
      with a total of 980 patients. The results showed that the ST (SBRT + TACE) group 
      had a longer OS (95% CIs 0.60-0.85, p = 0.0002), a higher 5-year OS rate (95% CI 
      1.01-2.04, p = 0.04), a higher rate of complete response (95% CI 1.08-1.90, p = 
      0.01), and a higher disease control rate (95% CI 1.02-1.16, p = 0.02) than the SA 
      (SBRT alone) group. No significant difference was found in LCS, PFS and total AEs 
      of all grades and grades 3-5 AEs between the 2 groups. In the subgroup analysis, 
      the patients with HCC + PVTT or treated with SBRT followed by TACE in the ST 
      group had the same OS as those in the SA group, and the patients in the ST group 
      had a higher incidence rate of leukopenia and fever than those in the SA group. 
      CONCLUSION: SBRT + TACE appears to be more effective than SBRT alone in treating 
      unresectable HCC. However, its higher incidence rate of leukopenia and fever need 
      to be monitored.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Zhao, Jiani
AU  - Zhao J
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
AD  - Department of Nuclear Medicine, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Zeng, Lianli
AU  - Zeng L
AD  - Department of Nuclear Medicine, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Wu, Qian
AU  - Wu Q
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Wang, Li
AU  - Wang L
AD  - Jiangxi Medical College, Nanchang University, Nanchang, China.
FAU - Lei, Jun
AU  - Lei J
AD  - Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Luo, Hongliang
AU  - Luo H
AD  - Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Yi, Fengming
AU  - Yi F
AD  - Department of Digestive Oncology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Wei, Yiping
AU  - Wei Y
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Yu, Jiao
AU  - Yu J
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China, yujiao2820@163.com.
FAU - Zhang, Wenxiong
AU  - Zhang W
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, China.
LA  - eng
PT  - Journal Article
DEP - 20200422
PL  - Switzerland
TA  - Chemotherapy
JT  - Chemotherapy
JID - 0144731
SB  - IM
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - Meta-analysis
OT  - Stereotactic body radiotherapy
OT  - Systematic review
OT  - Transcatheter arterial chemoembolization
EDAT- 2020/04/23 06:00
MHDA- 2020/04/23 06:01
CRDT- 2020/04/23 06:00
PHST- 2019/10/24 00:00 [received]
PHST- 2020/01/06 00:00 [accepted]
PHST- 2020/04/23 06:00 [pubmed]
PHST- 2020/04/23 06:01 [medline]
PHST- 2020/04/23 06:00 [entrez]
AID - 000505739 [pii]
AID - 10.1159/000505739 [doi]
PST - ppublish
SO  - Chemotherapy. 2019;64(5-6):248-258. doi: 10.1159/000505739. Epub 2020 Apr 22.